V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1994 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/541 |
Resumo: | This work was partially supported by Grants ROI-HL-48367 and ROI-AI-32885 (NIH), by the NAID/PAHO/Brazilian Ministry of Health, and by the AIDS Programa da FIOCRUZ Brazilian Ministry of Health. 1. |
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Morgado, Mariza GonçalvesSabino, Ester C.Shpaer, Eugene G.Bongertz, VeraBrigido, Luis F.Guimaraes, Mark Drew CroslandCastilho, Euclides Ayres deCastro Filho, Bernardo GalvãoMullins, James I.Hendry, R. MichaelMayer, Allen2010-08-23T16:58:21Z2010-11-04T14:19:42Z2010-08-23T16:58:21Z2010-11-04T14:19:42Z1994MORGADO, Mariza G. et al. V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F. AIDS Research and Human Retroviruses, v. 10, n. 5, p. 569-576, 1994.0889-2229https://www.arca.fiocruz.br/handle/icict/54110.1089/aid.1994.10.569This work was partially supported by Grants ROI-HL-48367 and ROI-AI-32885 (NIH), by the NAID/PAHO/Brazilian Ministry of Health, and by the AIDS Programa da FIOCRUZ Brazilian Ministry of Health. 1.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Department of Immunology. Rio de Janeiro, RJ, Brazil.Instituto Adolfo Lutz. São Paulo, SP, Brazil.Stanford University. School of Medicine. Department of Microbiology and Immunology. Stanford, CA, USA.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Department of Immunology. Rio de Janeiro, RJ, Brazil.Instituto Adolfo Lutz. São Paulo, SP, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Gonçalo Muniz Institute. Salvador, BA, Brazil.Yiral and Rickettsial Disease Laboratory, California Department of Health Services. Berkeley, CaliforniaViral DNA sequences were determined over the V3 region of env from 28 infected individuals living in the high mV·l prevalence Brazilian cities of Rio de Janeiro and São Paulo. Twenty-six belonged to envelope sequence subtype B, prevalent in North America and Europe, and one was c1assifiedas subtype F, found recently in Brazil and in Romania (one appeared to be a B/F recombinant). Octameric sequences at the tip of the subtype B V3 loops were variable and distinct from those prevalent in North America and Europe. The GPGR motü, prevalent in North AmericanlEuropean strains, was found in only 8 (28.5%) sequences, whereas GWGR was found in 12 (43%) and novel sequences in 8 (28.5%). Brazilian subtype B sequences also diverged from the consensus North AmericanlEuropean strains over the remainder of the V3loop. These results suggest that Brazilian mv·l B strains may have important antigenic differences from prototype subtype B strains currently being evaluated for use in HIV vaccines. These results should be taken into account for future vaccine programs in Brazil.engMary Ann Liebert, Inc., PublishersV3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype Finfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDNA, ViralAIDS VaccinesVaccinesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTCastilho_V3 Region Polymorphisms_1994---.pdf.txtCastilho_V3 Region Polymorphisms_1994---.pdf.txtExtracted texttext/plain40529https://www.arca.fiocruz.br/bitstream/icict/541/6/Castilho_V3%20Region%20Polymorphisms_1994---.pdf.txtdf4297d2b70130f529b3f8856f673504MD56LICENSElicense.txttext/plain1842https://www.arca.fiocruz.br/bitstream/icict/541/2/license.txtc6d856a4fff480a799b3afb2acbff224MD52ORIGINALCastilho_V3 Region Polymorphisms_1994---.pdfapplication/pdf1916500https://www.arca.fiocruz.br/bitstream/icict/541/3/Castilho_V3%20Region%20Polymorphisms_1994---.pdf7e8deb6f669635a58afc14adda9cda3bMD53THUMBNAILCastilho_V3 Region Polymorphisms_1994---.pdf.jpgCastilho_V3 Region Polymorphisms_1994---.pdf.jpgGenerated Thumbnailimage/jpeg1389https://www.arca.fiocruz.br/bitstream/icict/541/5/Castilho_V3%20Region%20Polymorphisms_1994---.pdf.jpg7e9db46dafc353bf8f03c0ea24865f2bMD55icict/5412022-06-24 13:08:49.518oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:08:49Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F |
| title |
V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F |
| spellingShingle |
V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F Morgado, Mariza Gonçalves DNA, Viral AIDS Vaccines Vaccines |
| title_short |
V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F |
| title_full |
V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F |
| title_fullStr |
V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F |
| title_full_unstemmed |
V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F |
| title_sort |
V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F |
| author |
Morgado, Mariza Gonçalves |
| author_facet |
Morgado, Mariza Gonçalves Sabino, Ester C. Shpaer, Eugene G. Bongertz, Vera Brigido, Luis F. Guimaraes, Mark Drew Crosland Castilho, Euclides Ayres de Castro Filho, Bernardo Galvão Mullins, James I. Hendry, R. Michael Mayer, Allen |
| author_role |
author |
| author2 |
Sabino, Ester C. Shpaer, Eugene G. Bongertz, Vera Brigido, Luis F. Guimaraes, Mark Drew Crosland Castilho, Euclides Ayres de Castro Filho, Bernardo Galvão Mullins, James I. Hendry, R. Michael Mayer, Allen |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Morgado, Mariza Gonçalves Sabino, Ester C. Shpaer, Eugene G. Bongertz, Vera Brigido, Luis F. Guimaraes, Mark Drew Crosland Castilho, Euclides Ayres de Castro Filho, Bernardo Galvão Mullins, James I. Hendry, R. Michael Mayer, Allen |
| dc.subject.en.none.fl_str_mv |
DNA, Viral AIDS Vaccines Vaccines |
| topic |
DNA, Viral AIDS Vaccines Vaccines |
| description |
This work was partially supported by Grants ROI-HL-48367 and ROI-AI-32885 (NIH), by the NAID/PAHO/Brazilian Ministry of Health, and by the AIDS Programa da FIOCRUZ Brazilian Ministry of Health. 1. |
| publishDate |
1994 |
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1994 |
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2010-08-23T16:58:21Z 2010-11-04T14:19:42Z |
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2010-08-23T16:58:21Z 2010-11-04T14:19:42Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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MORGADO, Mariza G. et al. V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F. AIDS Research and Human Retroviruses, v. 10, n. 5, p. 569-576, 1994. |
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https://www.arca.fiocruz.br/handle/icict/541 |
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0889-2229 |
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10.1089/aid.1994.10.569 |
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MORGADO, Mariza G. et al. V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F. AIDS Research and Human Retroviruses, v. 10, n. 5, p. 569-576, 1994. 0889-2229 10.1089/aid.1994.10.569 |
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Mary Ann Liebert, Inc., Publishers |
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