V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F

Detalhes bibliográficos
Autor(a) principal: Morgado, Mariza Gonçalves
Data de Publicação: 1994
Outros Autores: Sabino, Ester Cerdeira, Shpaer, Eugene G, Bongertz, Vera, Brigido, Luís Fernando de Macedo, Guimaraes, Mark Drew Crosland, Castilho, Euclides Ayres de, Castro Filho, Bernardo Galvão, Mullins, James I, Hendry, R Michael, Mayer, Allen
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15056
Resumo: FIOCRUZ. Instituto Oswaldo Cruz. Department of Immunology. Rio de Janeiro, RJ, Brasil
id CRUZ_9935b1b9904efb702768f135b672857f
oai_identifier_str oai:www.arca.fiocruz.br:icict/15056
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Morgado, Mariza GonçalvesSabino, Ester CerdeiraShpaer, Eugene GBongertz, VeraBrigido, Luís Fernando de MacedoGuimaraes, Mark Drew CroslandCastilho, Euclides Ayres deCastro Filho, Bernardo GalvãoMullins, James IHendry, R MichaelMayer, Allen2016-07-21T18:52:40Z2016-07-21T18:52:40Z1994MORGADO, M. G. et al. V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F. AIDS Research and Human Retroviruses, v. 10, n. 5, p. 569-576, 1994.0889-2229https://www.arca.fiocruz.br/handle/icict/1505610.1089/aid.1994.10.569engMary Ann LiebertV3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype Finfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFIOCRUZ. Instituto Oswaldo Cruz. Department of Immunology. Rio de Janeiro, RJ, BrasilInstituto Adolfo Lutz. São Paulo, SP, Brasil / Irwin Memorial Blood Centers. San Francisco, CaliforniaStanford University. School of Medicine. Department of Microbiology and Immunology. Stanford, CaliforniaFIOCRUZ. Instituto Oswaldo Cruz. Department of Immunology. Rio de Janeiro, RJ, BrasilInstituto Adolfo Lutz. São Paulo, SP, BrasilFIOCRUZ. Instituto Oswaldo Cruz. Centro de Info para a Saude. Rio de Janeiro, RJ, Brasil / Minas Gerais University. Department of Preventive Medicine. Minas Gerais, BH, BrasilFIOCRUZ. Instituto Oswaldo Cruz. Centro de Info para a Saude. Rio de Janeiro, RJ, BrasilFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilStanford University. School of Medicine. Department of Microbiology and Immunology. Stanford, CaliforniaViral and Rickettsial Disease Laboratory. California Department of Health Services. Berkeley, CaliforniaIrwin Memorial Blood Centers. San Francisco, CaliforniaViral DNA sequences were determined over the V3 region of env from 28 infected individuals living in the high HIV-1 prevalence Brazilian cities of Rio de Janeiro and São Paulo. Twenty-six belonged to envelope sequence subtype B, prevalent in North America and Europe, and one was classified as subtype F, found recently in Brazil and in Romania (one appeared to be a B/F recombinant). Octameric sequences at the tip of the subtype B V3 loops were variable and distinct from those prevalent in North America and Europe. The GPGR motif, prevalent in North American/European strains, was found in only 8 (28.5%) sequences, whereas GWGR was found in 12 (43%) and novel sequences in 8 (28.5%). Brazilian subtype B sequences also diverged from the consensus North American/European strains over the remainder of the V3 loop. These results suggest that Brazilian HIV-1 B strains may have important antigenic differences from prototype subtype B strains currently being evaluated for use in HIV vaccines. These results should be taken into account for future vaccine programs in Brazil.AIDS VaccinesAmino Acid SequenceDNA, ViralHIV InfectionsBrazilHIV-1HumansMolecular Sequence DataPhylogenyPolymerase Chain Reactioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15056/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMorgado MG V3 region polymorphisms....pdfMorgado MG V3 region polymorphisms....pdfapplication/pdf1171118https://www.arca.fiocruz.br/bitstream/icict/15056/2/Morgado%20MG%20V3%20region%20polymorphisms....pdf6e749afa631d2ad1129deda802733bbfMD52TEXTMorgado MG V3 region polymorphisms....pdf.txtMorgado MG V3 region polymorphisms....pdf.txtExtracted texttext/plain34725https://www.arca.fiocruz.br/bitstream/icict/15056/3/Morgado%20MG%20V3%20region%20polymorphisms....pdf.txt48b0d559d7af713f42a8cd56df07946dMD53icict/150562023-03-15 14:33:59.583oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F
title V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F
spellingShingle V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F
Morgado, Mariza Gonçalves
AIDS Vaccines
Amino Acid Sequence
DNA, Viral
HIV Infections
Brazil
HIV-1
Humans
Molecular Sequence Data
Phylogeny
Polymerase Chain Reaction
title_short V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F
title_full V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F
title_fullStr V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F
title_full_unstemmed V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F
title_sort V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F
author Morgado, Mariza Gonçalves
author_facet Morgado, Mariza Gonçalves
Sabino, Ester Cerdeira
Shpaer, Eugene G
Bongertz, Vera
Brigido, Luís Fernando de Macedo
Guimaraes, Mark Drew Crosland
Castilho, Euclides Ayres de
Castro Filho, Bernardo Galvão
Mullins, James I
Hendry, R Michael
Mayer, Allen
author_role author
author2 Sabino, Ester Cerdeira
Shpaer, Eugene G
Bongertz, Vera
Brigido, Luís Fernando de Macedo
Guimaraes, Mark Drew Crosland
Castilho, Euclides Ayres de
Castro Filho, Bernardo Galvão
Mullins, James I
Hendry, R Michael
Mayer, Allen
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Morgado, Mariza Gonçalves
Sabino, Ester Cerdeira
Shpaer, Eugene G
Bongertz, Vera
Brigido, Luís Fernando de Macedo
Guimaraes, Mark Drew Crosland
Castilho, Euclides Ayres de
Castro Filho, Bernardo Galvão
Mullins, James I
Hendry, R Michael
Mayer, Allen
dc.subject.en.pt_BR.fl_str_mv AIDS Vaccines
Amino Acid Sequence
DNA, Viral
HIV Infections
Brazil
HIV-1
Humans
Molecular Sequence Data
Phylogeny
Polymerase Chain Reaction
topic AIDS Vaccines
Amino Acid Sequence
DNA, Viral
HIV Infections
Brazil
HIV-1
Humans
Molecular Sequence Data
Phylogeny
Polymerase Chain Reaction
description FIOCRUZ. Instituto Oswaldo Cruz. Department of Immunology. Rio de Janeiro, RJ, Brasil
publishDate 1994
dc.date.issued.fl_str_mv 1994
dc.date.accessioned.fl_str_mv 2016-07-21T18:52:40Z
dc.date.available.fl_str_mv 2016-07-21T18:52:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MORGADO, M. G. et al. V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F. AIDS Research and Human Retroviruses, v. 10, n. 5, p. 569-576, 1994.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15056
dc.identifier.issn.pt_BR.fl_str_mv 0889-2229
dc.identifier.doi.none.fl_str_mv 10.1089/aid.1994.10.569
identifier_str_mv MORGADO, M. G. et al. V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F. AIDS Research and Human Retroviruses, v. 10, n. 5, p. 569-576, 1994.
0889-2229
10.1089/aid.1994.10.569
url https://www.arca.fiocruz.br/handle/icict/15056
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/15056/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/15056/2/Morgado%20MG%20V3%20region%20polymorphisms....pdf
https://www.arca.fiocruz.br/bitstream/icict/15056/3/Morgado%20MG%20V3%20region%20polymorphisms....pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
6e749afa631d2ad1129deda802733bbf
48b0d559d7af713f42a8cd56df07946d
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813008891092402176

Registros relacionados