Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus

Detalhes bibliográficos
Autor(a) principal: Melani, Rafael D.
Data de Publicação: 2015
Outros Autores: Araujo, Gabriel D.T., Carvalho, Paulo Costa, Goto, Livia, Nogueira, Fábio Cesar Sousa, Junqueira, Magno, Domont, Gilberto B.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/22779
Resumo: Universidade Federal do Rio de Janeiro. Departamento de Bioquímica. Rede Proteômica do Rio de Janeiro. Unidade Proteômica. Rio de Janeiro, RJ, Brasil.
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spelling Melani, Rafael D.Araujo, Gabriel D.T.Carvalho, Paulo CostaGoto, LiviaNogueira, Fábio Cesar SousaJunqueira, MagnoDomont, Gilberto B.2017-10-05T13:23:19Z2017-10-05T13:23:19Z2015MELANI, Rafael D. et al. Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus. EuPA Open Proteomics, v. 8, p. 144-156, 2015.2212-9685https://www.arca.fiocruz.br/handle/icict/2277910.1016/j.euprot.2015.05.006porElsevierCrotalus cascavellaCrotalus durissus terrificusCrotalid VenomsProteomicsBiological ToxinsVenenos de CrotálidosProteómicaToxinas BiológicasVenenos de CrotalídeosProteômicaToxinas BiológicasSeeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Departamento de Bioquímica. Rede Proteômica do Rio de Janeiro. Unidade Proteômica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Bioquímica. Rede Proteômica do Rio de Janeiro. Unidade Proteômica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica e Engenharia de Proteínas. Curitiba, PR, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Bioquímica. Rede Proteômica do Rio de Janeiro. Unidade Proteômica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Bioquímica. Rede Proteômica do Rio de Janeiro. Unidade Proteômica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Bioquímica. Rede Proteômica do Rio de Janeiro. Unidade Proteômica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Bioquímica. Rede Proteômica do Rio de Janeiro. Unidade Proteômica. Rio de Janeiro, RJ, Brasil.The complete characterization of the snake venom protein components is a requirement for a systems-wide understanding of their biological context. In this work, we provide a deep proteomic characterization of Crotalus durissus terrificus venom using different bottom-up approaches. We identified more than five times more protein families than the sum of all identifications previously reported. For the first time in this sub-species, we report the identification of three new toxin families: CRISP, phospholipase-B, and SVVEGF. This work also describes proteins involved in regulation of toxin synthesis and processing that are present in venom.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/22779/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALmelaniSeeingok.pdfmelaniSeeingok.pdfapplication/pdf2022243https://www.arca.fiocruz.br/bitstream/icict/22779/2/melaniSeeingok.pdfaf40fd146ab51b3642423c42bdca7a74MD52TEXTmelaniSeeingok.pdf.txtmelaniSeeingok.pdf.txtExtracted texttext/plain77078https://www.arca.fiocruz.br/bitstream/icict/22779/3/melaniSeeingok.pdf.txt5ef54df25bdd1628771f6e2b1ae03693MD53icict/227792019-11-01 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dc.title.pt_BR.fl_str_mv Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus
title Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus
spellingShingle Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus
Melani, Rafael D.
Crotalus cascavella
Crotalus durissus terrificus
Crotalid Venoms
Proteomics
Biological Toxins
Venenos de Crotálidos
Proteómica
Toxinas Biológicas
Venenos de Crotalídeos
Proteômica
Toxinas Biológicas
title_short Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus
title_full Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus
title_fullStr Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus
title_full_unstemmed Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus
title_sort Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus
author Melani, Rafael D.
author_facet Melani, Rafael D.
Araujo, Gabriel D.T.
Carvalho, Paulo Costa
Goto, Livia
Nogueira, Fábio Cesar Sousa
Junqueira, Magno
Domont, Gilberto B.
author_role author
author2 Araujo, Gabriel D.T.
Carvalho, Paulo Costa
Goto, Livia
Nogueira, Fábio Cesar Sousa
Junqueira, Magno
Domont, Gilberto B.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Melani, Rafael D.
Araujo, Gabriel D.T.
Carvalho, Paulo Costa
Goto, Livia
Nogueira, Fábio Cesar Sousa
Junqueira, Magno
Domont, Gilberto B.
dc.subject.other.pt_BR.fl_str_mv Crotalus cascavella
topic Crotalus cascavella
Crotalus durissus terrificus
Crotalid Venoms
Proteomics
Biological Toxins
Venenos de Crotálidos
Proteómica
Toxinas Biológicas
Venenos de Crotalídeos
Proteômica
Toxinas Biológicas
dc.subject.en.pt_BR.fl_str_mv Crotalus durissus terrificus
Crotalid Venoms
Proteomics
Biological Toxins
dc.subject.es.pt_BR.fl_str_mv Venenos de Crotálidos
Proteómica
Toxinas Biológicas
dc.subject.decs.pt_BR.fl_str_mv Venenos de Crotalídeos
Proteômica
Toxinas Biológicas
description Universidade Federal do Rio de Janeiro. Departamento de Bioquímica. Rede Proteômica do Rio de Janeiro. Unidade Proteômica. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2017-10-05T13:23:19Z
dc.date.available.fl_str_mv 2017-10-05T13:23:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv MELANI, Rafael D. et al. Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus. EuPA Open Proteomics, v. 8, p. 144-156, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/22779
dc.identifier.issn.pt_BR.fl_str_mv 2212-9685
dc.identifier.doi.none.fl_str_mv 10.1016/j.euprot.2015.05.006
identifier_str_mv MELANI, Rafael D. et al. Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus. EuPA Open Proteomics, v. 8, p. 144-156, 2015.
2212-9685
10.1016/j.euprot.2015.05.006
url https://www.arca.fiocruz.br/handle/icict/22779
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
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