Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/22779 |
Resumo: | Universidade Federal do Rio de Janeiro. Departamento de Bioquímica. Rede Proteômica do Rio de Janeiro. Unidade Proteômica. Rio de Janeiro, RJ, Brasil. |
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Melani, Rafael D.Araujo, Gabriel D.T.Carvalho, Paulo CostaGoto, LiviaNogueira, Fábio Cesar SousaJunqueira, MagnoDomont, Gilberto B.2017-10-05T13:23:19Z2017-10-05T13:23:19Z2015MELANI, Rafael D. et al. Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus. EuPA Open Proteomics, v. 8, p. 144-156, 2015.2212-9685https://www.arca.fiocruz.br/handle/icict/2277910.1016/j.euprot.2015.05.006porElsevierCrotalus cascavellaCrotalus durissus terrificusCrotalid VenomsProteomicsBiological ToxinsVenenos de CrotálidosProteómicaToxinas BiológicasVenenos de CrotalídeosProteômicaToxinas BiológicasSeeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Departamento de Bioquímica. Rede Proteômica do Rio de Janeiro. Unidade Proteômica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Bioquímica. Rede Proteômica do Rio de Janeiro. Unidade Proteômica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica e Engenharia de Proteínas. Curitiba, PR, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Bioquímica. Rede Proteômica do Rio de Janeiro. Unidade Proteômica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Bioquímica. Rede Proteômica do Rio de Janeiro. Unidade Proteômica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Bioquímica. Rede Proteômica do Rio de Janeiro. Unidade Proteômica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Bioquímica. Rede Proteômica do Rio de Janeiro. Unidade Proteômica. Rio de Janeiro, RJ, Brasil.The complete characterization of the snake venom protein components is a requirement for a systems-wide understanding of their biological context. In this work, we provide a deep proteomic characterization of Crotalus durissus terrificus venom using different bottom-up approaches. We identified more than five times more protein families than the sum of all identifications previously reported. For the first time in this sub-species, we report the identification of three new toxin families: CRISP, phospholipase-B, and SVVEGF. This work also describes proteins involved in regulation of toxin synthesis and processing that are present in venom.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/22779/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALmelaniSeeingok.pdfmelaniSeeingok.pdfapplication/pdf2022243https://www.arca.fiocruz.br/bitstream/icict/22779/2/melaniSeeingok.pdfaf40fd146ab51b3642423c42bdca7a74MD52TEXTmelaniSeeingok.pdf.txtmelaniSeeingok.pdf.txtExtracted texttext/plain77078https://www.arca.fiocruz.br/bitstream/icict/22779/3/melaniSeeingok.pdf.txt5ef54df25bdd1628771f6e2b1ae03693MD53icict/227792019-11-01 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dc.title.pt_BR.fl_str_mv |
Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus |
title |
Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus |
spellingShingle |
Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus Melani, Rafael D. Crotalus cascavella Crotalus durissus terrificus Crotalid Venoms Proteomics Biological Toxins Venenos de Crotálidos Proteómica Toxinas Biológicas Venenos de Crotalídeos Proteômica Toxinas Biológicas |
title_short |
Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus |
title_full |
Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus |
title_fullStr |
Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus |
title_full_unstemmed |
Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus |
title_sort |
Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus |
author |
Melani, Rafael D. |
author_facet |
Melani, Rafael D. Araujo, Gabriel D.T. Carvalho, Paulo Costa Goto, Livia Nogueira, Fábio Cesar Sousa Junqueira, Magno Domont, Gilberto B. |
author_role |
author |
author2 |
Araujo, Gabriel D.T. Carvalho, Paulo Costa Goto, Livia Nogueira, Fábio Cesar Sousa Junqueira, Magno Domont, Gilberto B. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Melani, Rafael D. Araujo, Gabriel D.T. Carvalho, Paulo Costa Goto, Livia Nogueira, Fábio Cesar Sousa Junqueira, Magno Domont, Gilberto B. |
dc.subject.other.pt_BR.fl_str_mv |
Crotalus cascavella |
topic |
Crotalus cascavella Crotalus durissus terrificus Crotalid Venoms Proteomics Biological Toxins Venenos de Crotálidos Proteómica Toxinas Biológicas Venenos de Crotalídeos Proteômica Toxinas Biológicas |
dc.subject.en.pt_BR.fl_str_mv |
Crotalus durissus terrificus Crotalid Venoms Proteomics Biological Toxins |
dc.subject.es.pt_BR.fl_str_mv |
Venenos de Crotálidos Proteómica Toxinas Biológicas |
dc.subject.decs.pt_BR.fl_str_mv |
Venenos de Crotalídeos Proteômica Toxinas Biológicas |
description |
Universidade Federal do Rio de Janeiro. Departamento de Bioquímica. Rede Proteômica do Rio de Janeiro. Unidade Proteômica. Rio de Janeiro, RJ, Brasil. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2017-10-05T13:23:19Z |
dc.date.available.fl_str_mv |
2017-10-05T13:23:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MELANI, Rafael D. et al. Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus. EuPA Open Proteomics, v. 8, p. 144-156, 2015. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/22779 |
dc.identifier.issn.pt_BR.fl_str_mv |
2212-9685 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.euprot.2015.05.006 |
identifier_str_mv |
MELANI, Rafael D. et al. Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus. EuPA Open Proteomics, v. 8, p. 144-156, 2015. 2212-9685 10.1016/j.euprot.2015.05.006 |
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https://www.arca.fiocruz.br/handle/icict/22779 |
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Elsevier |
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Elsevier |
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