Correction to: in vivo and in vitro taste assessment of artesunate-mefloquine, praziquantel, and benznidazole drugs for neglected tropical diseases and pediatric patients

Detalhes bibliográficos
Autor(a) principal: Boniatti, Janine
Data de Publicação: 2022
Outros Autores: Tappin, Marcelo R. R., Teixeira, Rafaela G. da S., Gandos, Tamires A. V., Rios, Luis P. S., Ferreira, Izabelle A. M., Oliveira, Karina C., Calil-Elias, Sabrina, Santana, Aila K. M., Fonseca, Laís B. da, Shimizu, Flavio M., Carr, Olívia, Oliveira Jr, Osvaldo N., Dantas, Fabio M. L., Amendoeira, Fabio C., Viçosa, Alessandra L .
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/52521
Resumo: The authors are grateful for the fnancial support by PAPES VII, PROEP/FAR/CNPq/Fiocruz, CNPQ, and FAPESP (2018/22214-6). Also, we would like to thank Luciano Simoes Pereirafor all support with the image treatment and the recirculation system construction. The authors also thank Angelo L. Gobbi and Maria H. O. Piazzetta for their technical assistance in the microfabrication laboratory (LMF/LNNano/CNPEM).
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spelling Boniatti, JanineTappin, Marcelo R. R.Teixeira, Rafaela G. da S.Gandos, Tamires A. V.Rios, Luis P. S.Ferreira, Izabelle A. M.Oliveira, Karina C.Calil-Elias, SabrinaSantana, Aila K. M.Fonseca, Laís B. daShimizu, Flavio M.Carr, OlíviaOliveira Jr, Osvaldo N.Dantas, Fabio M. L.Amendoeira, Fabio C.Viçosa, Alessandra L .2022-05-03T19:30:36Z2022-05-03T19:30:36Z2022Boniatti, Janine. et al. In vivo and in vitro taste assessment of artesunate-mefloquine, praziquantel, and benznidazole drugs for neglected tropical diseases and pediatric patients. AAPS PharmSciTech v. 23, n. 22, 2022.https://www.arca.fiocruz.br/handle/icict/5252110.1208/s12249-022-02216-wThe authors are grateful for the fnancial support by PAPES VII, PROEP/FAR/CNPq/Fiocruz, CNPQ, and FAPESP (2018/22214-6). Also, we would like to thank Luciano Simoes Pereirafor all support with the image treatment and the recirculation system construction. The authors also thank Angelo L. Gobbi and Maria H. O. Piazzetta for their technical assistance in the microfabrication laboratory (LMF/LNNano/CNPEM).Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. / Instituto Nacional de Tecnologia. Rio de Janeiro, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, BrasilUniversidade Federal Fluminense. Instituto de Farmácia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Instituto de Farmácia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Farmácia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Farmácia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Farmácia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Farmácia. Niterói, RJ, Brasil.Laboratório Farmacêutico de Pernambuco. Recife, PE, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, BrasilUniversidade de Campinas. Campinas, SP, Brasil.Universidade de São Carlos. São Carlos, SP, Brasil.Universidade de São Carlos. São Carlos, SP, Brasil.Instituto Nacional de Tecnologia. Rio de Janeiro, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Rio de Janeiro, RJ, BrasilThe assessment of drug taste is crucial for pediatric treatments so that formulations can be developed to enhance their efectiveness. In this study, in vivo and in vitro methods were applied to evaluate the taste of tablets of three drugs administered to children without taste-masking excipients to treat tropical diseases, namely artesunate-mefoquine (ASMQ), praziquantel (PZQ), and benznidazole (BNZ). In the frst method, a model of rat palatability was adapted with recirculation to ensure sample dispersion, and the data were analyzed using ANOVA (single factor, 95%). The taste assessment results (in vivo) indicated an aversion to the three medicines, denoted by the animals retracting themselves to the bottom of the box after the frst contact with the drugs. For the placebo samples, the animals behaved normally, indicating that taste perception was acceptable. The second method was based on the in vitro analysis of capacitance data from a homemade impedimetric electronic tongue. Consistent with the in vivo taste assessment results, the data points obtained with PZQ, ASMQ, and BNZ were far away from those of their placebos in a map built with the multidimensional projection technique referred to as Interactive Document Mapping (IDMAP). A combined analysis of the results with the two methods allowed us to confrm the bitterness of the three drugs, also pointing to electronic tongues as a promising tool to replace in vivo palatability tests.engAAPS PharmSciTechCorrection to: in vivo and in vitro taste assessment of artesunate-mefloquine, praziquantel, and benznidazole drugs for neglected tropical diseases and pediatric patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleOf-label usePediatric treatmentElectronic tongueModifed taste aversion modelArtesunate-mefoquineBenznidazoleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Correction to: in vivo and in vitro taste assessment of artesunate-mefloquine, praziquantel, and benznidazole drugs for neglected tropical diseases and pediatric patients
title Correction to: in vivo and in vitro taste assessment of artesunate-mefloquine, praziquantel, and benznidazole drugs for neglected tropical diseases and pediatric patients
spellingShingle Correction to: in vivo and in vitro taste assessment of artesunate-mefloquine, praziquantel, and benznidazole drugs for neglected tropical diseases and pediatric patients
Boniatti, Janine
Of-label use
Pediatric treatment
Electronic tongue
Modifed taste aversion model
Artesunate-mefoquine
Benznidazole
title_short Correction to: in vivo and in vitro taste assessment of artesunate-mefloquine, praziquantel, and benznidazole drugs for neglected tropical diseases and pediatric patients
title_full Correction to: in vivo and in vitro taste assessment of artesunate-mefloquine, praziquantel, and benznidazole drugs for neglected tropical diseases and pediatric patients
title_fullStr Correction to: in vivo and in vitro taste assessment of artesunate-mefloquine, praziquantel, and benznidazole drugs for neglected tropical diseases and pediatric patients
title_full_unstemmed Correction to: in vivo and in vitro taste assessment of artesunate-mefloquine, praziquantel, and benznidazole drugs for neglected tropical diseases and pediatric patients
title_sort Correction to: in vivo and in vitro taste assessment of artesunate-mefloquine, praziquantel, and benznidazole drugs for neglected tropical diseases and pediatric patients
author Boniatti, Janine
author_facet Boniatti, Janine
Tappin, Marcelo R. R.
Teixeira, Rafaela G. da S.
Gandos, Tamires A. V.
Rios, Luis P. S.
Ferreira, Izabelle A. M.
Oliveira, Karina C.
Calil-Elias, Sabrina
Santana, Aila K. M.
Fonseca, Laís B. da
Shimizu, Flavio M.
Carr, Olívia
Oliveira Jr, Osvaldo N.
Dantas, Fabio M. L.
Amendoeira, Fabio C.
Viçosa, Alessandra L .
author_role author
author2 Tappin, Marcelo R. R.
Teixeira, Rafaela G. da S.
Gandos, Tamires A. V.
Rios, Luis P. S.
Ferreira, Izabelle A. M.
Oliveira, Karina C.
Calil-Elias, Sabrina
Santana, Aila K. M.
Fonseca, Laís B. da
Shimizu, Flavio M.
Carr, Olívia
Oliveira Jr, Osvaldo N.
Dantas, Fabio M. L.
Amendoeira, Fabio C.
Viçosa, Alessandra L .
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Boniatti, Janine
Tappin, Marcelo R. R.
Teixeira, Rafaela G. da S.
Gandos, Tamires A. V.
Rios, Luis P. S.
Ferreira, Izabelle A. M.
Oliveira, Karina C.
Calil-Elias, Sabrina
Santana, Aila K. M.
Fonseca, Laís B. da
Shimizu, Flavio M.
Carr, Olívia
Oliveira Jr, Osvaldo N.
Dantas, Fabio M. L.
Amendoeira, Fabio C.
Viçosa, Alessandra L .
dc.subject.en.pt_BR.fl_str_mv Of-label use
Pediatric treatment
Electronic tongue
Modifed taste aversion model
Artesunate-mefoquine
Benznidazole
topic Of-label use
Pediatric treatment
Electronic tongue
Modifed taste aversion model
Artesunate-mefoquine
Benznidazole
description The authors are grateful for the fnancial support by PAPES VII, PROEP/FAR/CNPq/Fiocruz, CNPQ, and FAPESP (2018/22214-6). Also, we would like to thank Luciano Simoes Pereirafor all support with the image treatment and the recirculation system construction. The authors also thank Angelo L. Gobbi and Maria H. O. Piazzetta for their technical assistance in the microfabrication laboratory (LMF/LNNano/CNPEM).
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-05-03T19:30:36Z
dc.date.available.fl_str_mv 2022-05-03T19:30:36Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Boniatti, Janine. et al. In vivo and in vitro taste assessment of artesunate-mefloquine, praziquantel, and benznidazole drugs for neglected tropical diseases and pediatric patients. AAPS PharmSciTech v. 23, n. 22, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/52521
dc.identifier.doi.none.fl_str_mv 10.1208/s12249-022-02216-w
identifier_str_mv Boniatti, Janine. et al. In vivo and in vitro taste assessment of artesunate-mefloquine, praziquantel, and benznidazole drugs for neglected tropical diseases and pediatric patients. AAPS PharmSciTech v. 23, n. 22, 2022.
10.1208/s12249-022-02216-w
url https://www.arca.fiocruz.br/handle/icict/52521
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv AAPS PharmSciTech
publisher.none.fl_str_mv AAPS PharmSciTech
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/52521/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/52521/2/va_Janine_Boniatti_etal_Farmanguinhos_2022.pdf
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