Clinical characteristics and risk factors of human leptospirosis in Argentina (1999-2005)

Detalhes bibliográficos
Autor(a) principal: Vanasco, N. B
Data de Publicação: 2008
Outros Autores: Schmeling, M. F, Lottersberger, J, Costa, Federico, Ko, Albert Icksang, Tarablae, H. D
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12201
Resumo: Instituto Nacional de Enfermedades Respiratorias. INER “Dr. E. Coni”. Administración Nacional de Laboratorios e Institutos de Salud. ANLIS Dr. Carlos G. Malbrán. Santa Fe, Argentina / Facultad de Bioquímica y Ciencias Biológicas. Santa Fe, Argentina
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spelling Vanasco, N. BSchmeling, M. FLottersberger, JCosta, FedericoKo, Albert IcksangTarablae, H. D2015-11-12T12:05:28Z2015-11-12T12:05:28Z2008VANASCO, N. B et al. Clinical characteristics and risk factors of human leptospirosis in Argentina (1999-2005). Acta Tropica, v. 107, n. 3, p. 255-258, 2008.1873-6254https://www.arca.fiocruz.br/handle/icict/1220110.1016/j.actatropica.2008.06.007engElsevierClinical characteristics and risk factors of human leptospirosis in Argentina (1999-2005)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Nacional de Enfermedades Respiratorias. INER “Dr. E. Coni”. Administración Nacional de Laboratorios e Institutos de Salud. ANLIS Dr. Carlos G. Malbrán. Santa Fe, Argentina / Facultad de Bioquímica y Ciencias Biológicas. Santa Fe, ArgentinaInstituto Nacional de Enfermedades Respiratorias. INER “Dr. E. Coni”. Administración Nacional de Laboratorios e Institutos de Salud. ANLIS Dr. Carlos G. Malbrán. Santa Fe, ArgentinaFacultad de Bioquímica y Ciencias Biológicas. Santa Fe, ArgentinaFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Weill Medical College of Cornell University. Division of International Medicine and Infectious Disease. NY, USAINTA. Rafaela, ArgentinaThere is scarce data on the burden of leptospirosis and its epidemiological characteristics in Argentina. This study aimed to evaluate distribution of leptospirosis cases and identify risk factors for the disease during national laboratory-based surveillance. From January 1999 to December 2005, 812 suspected cases were referred to the national reference laboratory, of which 182 and 463 had respectively, laboratory confirmed and unconfirmed diagnosis of leptospirosis. The diagnosis of leptospirosis was discarded in 167 cases. The most prevalent presumptive infecting serogroup was Icterohaemorrhagie followed by Pomona, Ballum and Canicola. The majority of cases occurred during the worm and rainy months. Confirmed cases were predominantly adults and males, who presented with fever, headache and myalgias. Severe clinical manifestations included jaundice and acute renal insufficiency. Conjunctival suffusion, a hallmark clinical sign of leptospirosis, was found in 55% of confirmed cases, and 43% of the cases with discarded diagnosis (p=0.036). After multivariate analyses, age >30 years (OR=2.16; 1.05-4.41), occupation in a rural setting (OR=3.41; 1.45-8.06), contact with contaminated surface water (OR=2.17; 1.01-4.68), and contact with floods (OR=4.49; 1.17-17.25) were significantly associated with leptospirosis. In conclusion, although activities associated with rural occupations remain important risk factors in Argentina, exposures occurring during flooding events have emerged to be the major risk factor for leptospirosis.LeptospirosisEpidemiologyRisk factorsMicroscopic agglutination testRural transmissionArgentinaLeptospira/isolamento & purificaçãoLeptospirose/epidemiologiaLeptospirose/fisiopatologiaAdultoFatores EtáriosArgentina/epidemiologiaFemininoHumanosIncidênciaLeptospira/classificaçãoLeptospirose/complicaçõesMasculinoMeis-IdadeFatores de RiscoEstações do AnoFatores Sexuaisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12201/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVanasco N Clinical characteristics and risk....pdfVanasco N Clinical characteristics and 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dc.title.pt_BR.fl_str_mv Clinical characteristics and risk factors of human leptospirosis in Argentina (1999-2005)
title Clinical characteristics and risk factors of human leptospirosis in Argentina (1999-2005)
spellingShingle Clinical characteristics and risk factors of human leptospirosis in Argentina (1999-2005)
Vanasco, N. B
Leptospirosis
Epidemiology
Risk factors
Microscopic agglutination test
Rural transmission
Argentina
Leptospira/isolamento & purificação
Leptospirose/epidemiologia
Leptospirose/fisiopatologia
Adulto
Fatores Etários
Argentina/epidemiologia
Feminino
Humanos
Incidência
Leptospira/classificação
Leptospirose/complicações
Masculino
Meis-Idade
Fatores de Risco
Estações do Ano
Fatores Sexuais
title_short Clinical characteristics and risk factors of human leptospirosis in Argentina (1999-2005)
title_full Clinical characteristics and risk factors of human leptospirosis in Argentina (1999-2005)
title_fullStr Clinical characteristics and risk factors of human leptospirosis in Argentina (1999-2005)
title_full_unstemmed Clinical characteristics and risk factors of human leptospirosis in Argentina (1999-2005)
title_sort Clinical characteristics and risk factors of human leptospirosis in Argentina (1999-2005)
author Vanasco, N. B
author_facet Vanasco, N. B
Schmeling, M. F
Lottersberger, J
Costa, Federico
Ko, Albert Icksang
Tarablae, H. D
author_role author
author2 Schmeling, M. F
Lottersberger, J
Costa, Federico
Ko, Albert Icksang
Tarablae, H. D
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Vanasco, N. B
Schmeling, M. F
Lottersberger, J
Costa, Federico
Ko, Albert Icksang
Tarablae, H. D
dc.subject.en.pt_BR.fl_str_mv Leptospirosis
Epidemiology
Risk factors
Microscopic agglutination test
Rural transmission
Argentina
topic Leptospirosis
Epidemiology
Risk factors
Microscopic agglutination test
Rural transmission
Argentina
Leptospira/isolamento & purificação
Leptospirose/epidemiologia
Leptospirose/fisiopatologia
Adulto
Fatores Etários
Argentina/epidemiologia
Feminino
Humanos
Incidência
Leptospira/classificação
Leptospirose/complicações
Masculino
Meis-Idade
Fatores de Risco
Estações do Ano
Fatores Sexuais
dc.subject.decs.pt_BR.fl_str_mv Leptospira/isolamento & purificação
Leptospirose/epidemiologia
Leptospirose/fisiopatologia
Adulto
Fatores Etários
Argentina/epidemiologia
Feminino
Humanos
Incidência
Leptospira/classificação
Leptospirose/complicações
Masculino
Meis-Idade
Fatores de Risco
Estações do Ano
Fatores Sexuais
description Instituto Nacional de Enfermedades Respiratorias. INER “Dr. E. Coni”. Administración Nacional de Laboratorios e Institutos de Salud. ANLIS Dr. Carlos G. Malbrán. Santa Fe, Argentina / Facultad de Bioquímica y Ciencias Biológicas. Santa Fe, Argentina
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2015-11-12T12:05:28Z
dc.date.available.fl_str_mv 2015-11-12T12:05:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VANASCO, N. B et al. Clinical characteristics and risk factors of human leptospirosis in Argentina (1999-2005). Acta Tropica, v. 107, n. 3, p. 255-258, 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12201
dc.identifier.issn.none.fl_str_mv 1873-6254
dc.identifier.doi.none.fl_str_mv 10.1016/j.actatropica.2008.06.007
identifier_str_mv VANASCO, N. B et al. Clinical characteristics and risk factors of human leptospirosis in Argentina (1999-2005). Acta Tropica, v. 107, n. 3, p. 255-258, 2008.
1873-6254
10.1016/j.actatropica.2008.06.007
url https://www.arca.fiocruz.br/handle/icict/12201
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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