Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Raquel F.
Data de Publicação: 2009
Outros Autores: Charret, Karen S., Silva, Edson F. da, Echevarria, Aurea, Amaral, Verônica F., Leon, Leonor L., Canto-Cavalheiro, Marilene M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30811
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.
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spelling Rodrigues, Raquel F.Charret, Karen S.Silva, Edson F. daEchevarria, AureaAmaral, Verônica F.Leon, Leonor L.Canto-Cavalheiro, Marilene M.2018-12-31T13:25:55Z2018-12-31T13:25:55Z2009RODRIGUES, Raquel F. et l. Antileishmanial Activity of 1,3,4-Thiadiazolium-2-Aminide in Mice Infected with Leishmania amazonensis. Antimicrobial Agents and Chemotherapy, v.53, n.2, p.839-842, Feb. 2009.0066-4804https://www.arca.fiocruz.br/handle/icict/3081110.1128/AAC.00062-08engAmerican Society for MicrobiologyAtividade AntileishmanialLeishmania amazonensisRatosInfecçãoAntileishmanial ActivityMiceLeishmania amazonensisInfection1,3,4-Thiadiazolium-2-AminideAntileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Imunologia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.The efficacy of two mesoionic derivatives (MI-H-H and MI-4-OCH(3)) was evaluated in CBA/J mice infected with Leishmania amazonensis. Treatment with these compounds demonstrated that the MI-4-OCH(3) derivative and the reference drug meglumine antimoniate (Glucantime) presented significant activity relative to an untreated control. No apparent hepatic or renal toxicity due to these mesoionic compounds was found.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30811/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmarilene_cavalheiro_etal_IOC_2009.pdfmarilene_cavalheiro_etal_IOC_2009.pdfapplication/pdf357778https://www.arca.fiocruz.br/bitstream/icict/30811/2/marilene_cavalheiro_etal_IOC_2009.pdf66894637f6bdd3322a61ee4b0c0f2a5fMD52TEXTmarilene_cavalheiro_etal_IOC_2009.pdf.txtmarilene_cavalheiro_etal_IOC_2009.pdf.txtExtracted texttext/plain18846https://www.arca.fiocruz.br/bitstream/icict/30811/3/marilene_cavalheiro_etal_IOC_2009.pdf.txtd34cbf4db12b4215040eec7a024fed6fMD53icict/308112019-01-01 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dc.title.pt_BR.fl_str_mv Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis
title Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis
spellingShingle Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis
Rodrigues, Raquel F.
Atividade Antileishmanial
Leishmania amazonensis
Ratos
Infecção
Antileishmanial Activity
Mice
Leishmania amazonensis
Infection
1,3,4-Thiadiazolium-2-Aminide
title_short Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis
title_full Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis
title_fullStr Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis
title_full_unstemmed Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis
title_sort Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis
author Rodrigues, Raquel F.
author_facet Rodrigues, Raquel F.
Charret, Karen S.
Silva, Edson F. da
Echevarria, Aurea
Amaral, Verônica F.
Leon, Leonor L.
Canto-Cavalheiro, Marilene M.
author_role author
author2 Charret, Karen S.
Silva, Edson F. da
Echevarria, Aurea
Amaral, Verônica F.
Leon, Leonor L.
Canto-Cavalheiro, Marilene M.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues, Raquel F.
Charret, Karen S.
Silva, Edson F. da
Echevarria, Aurea
Amaral, Verônica F.
Leon, Leonor L.
Canto-Cavalheiro, Marilene M.
dc.subject.other.pt_BR.fl_str_mv Atividade Antileishmanial
Leishmania amazonensis
Ratos
Infecção
topic Atividade Antileishmanial
Leishmania amazonensis
Ratos
Infecção
Antileishmanial Activity
Mice
Leishmania amazonensis
Infection
1,3,4-Thiadiazolium-2-Aminide
dc.subject.en.pt_BR.fl_str_mv Antileishmanial Activity
Mice
Leishmania amazonensis
Infection
1,3,4-Thiadiazolium-2-Aminide
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2018-12-31T13:25:55Z
dc.date.available.fl_str_mv 2018-12-31T13:25:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RODRIGUES, Raquel F. et l. Antileishmanial Activity of 1,3,4-Thiadiazolium-2-Aminide in Mice Infected with Leishmania amazonensis. Antimicrobial Agents and Chemotherapy, v.53, n.2, p.839-842, Feb. 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30811
dc.identifier.issn.pt_BR.fl_str_mv 0066-4804
dc.identifier.doi.none.fl_str_mv 10.1128/AAC.00062-08
identifier_str_mv RODRIGUES, Raquel F. et l. Antileishmanial Activity of 1,3,4-Thiadiazolium-2-Aminide in Mice Infected with Leishmania amazonensis. Antimicrobial Agents and Chemotherapy, v.53, n.2, p.839-842, Feb. 2009.
0066-4804
10.1128/AAC.00062-08
url https://www.arca.fiocruz.br/handle/icict/30811
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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