Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/30811 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil. |
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Rodrigues, Raquel F.Charret, Karen S.Silva, Edson F. daEchevarria, AureaAmaral, Verônica F.Leon, Leonor L.Canto-Cavalheiro, Marilene M.2018-12-31T13:25:55Z2018-12-31T13:25:55Z2009RODRIGUES, Raquel F. et l. Antileishmanial Activity of 1,3,4-Thiadiazolium-2-Aminide in Mice Infected with Leishmania amazonensis. Antimicrobial Agents and Chemotherapy, v.53, n.2, p.839-842, Feb. 2009.0066-4804https://www.arca.fiocruz.br/handle/icict/3081110.1128/AAC.00062-08engAmerican Society for MicrobiologyAtividade AntileishmanialLeishmania amazonensisRatosInfecçãoAntileishmanial ActivityMiceLeishmania amazonensisInfection1,3,4-Thiadiazolium-2-AminideAntileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Imunologia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.The efficacy of two mesoionic derivatives (MI-H-H and MI-4-OCH(3)) was evaluated in CBA/J mice infected with Leishmania amazonensis. Treatment with these compounds demonstrated that the MI-4-OCH(3) derivative and the reference drug meglumine antimoniate (Glucantime) presented significant activity relative to an untreated control. No apparent hepatic or renal toxicity due to these mesoionic compounds was found.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30811/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmarilene_cavalheiro_etal_IOC_2009.pdfmarilene_cavalheiro_etal_IOC_2009.pdfapplication/pdf357778https://www.arca.fiocruz.br/bitstream/icict/30811/2/marilene_cavalheiro_etal_IOC_2009.pdf66894637f6bdd3322a61ee4b0c0f2a5fMD52TEXTmarilene_cavalheiro_etal_IOC_2009.pdf.txtmarilene_cavalheiro_etal_IOC_2009.pdf.txtExtracted texttext/plain18846https://www.arca.fiocruz.br/bitstream/icict/30811/3/marilene_cavalheiro_etal_IOC_2009.pdf.txtd34cbf4db12b4215040eec7a024fed6fMD53icict/308112019-01-01 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dc.title.pt_BR.fl_str_mv |
Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis |
title |
Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis |
spellingShingle |
Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis Rodrigues, Raquel F. Atividade Antileishmanial Leishmania amazonensis Ratos Infecção Antileishmanial Activity Mice Leishmania amazonensis Infection 1,3,4-Thiadiazolium-2-Aminide |
title_short |
Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis |
title_full |
Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis |
title_fullStr |
Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis |
title_full_unstemmed |
Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis |
title_sort |
Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis |
author |
Rodrigues, Raquel F. |
author_facet |
Rodrigues, Raquel F. Charret, Karen S. Silva, Edson F. da Echevarria, Aurea Amaral, Verônica F. Leon, Leonor L. Canto-Cavalheiro, Marilene M. |
author_role |
author |
author2 |
Charret, Karen S. Silva, Edson F. da Echevarria, Aurea Amaral, Verônica F. Leon, Leonor L. Canto-Cavalheiro, Marilene M. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Rodrigues, Raquel F. Charret, Karen S. Silva, Edson F. da Echevarria, Aurea Amaral, Verônica F. Leon, Leonor L. Canto-Cavalheiro, Marilene M. |
dc.subject.other.pt_BR.fl_str_mv |
Atividade Antileishmanial Leishmania amazonensis Ratos Infecção |
topic |
Atividade Antileishmanial Leishmania amazonensis Ratos Infecção Antileishmanial Activity Mice Leishmania amazonensis Infection 1,3,4-Thiadiazolium-2-Aminide |
dc.subject.en.pt_BR.fl_str_mv |
Antileishmanial Activity Mice Leishmania amazonensis Infection 1,3,4-Thiadiazolium-2-Aminide |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2018-12-31T13:25:55Z |
dc.date.available.fl_str_mv |
2018-12-31T13:25:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
RODRIGUES, Raquel F. et l. Antileishmanial Activity of 1,3,4-Thiadiazolium-2-Aminide in Mice Infected with Leishmania amazonensis. Antimicrobial Agents and Chemotherapy, v.53, n.2, p.839-842, Feb. 2009. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/30811 |
dc.identifier.issn.pt_BR.fl_str_mv |
0066-4804 |
dc.identifier.doi.none.fl_str_mv |
10.1128/AAC.00062-08 |
identifier_str_mv |
RODRIGUES, Raquel F. et l. Antileishmanial Activity of 1,3,4-Thiadiazolium-2-Aminide in Mice Infected with Leishmania amazonensis. Antimicrobial Agents and Chemotherapy, v.53, n.2, p.839-842, Feb. 2009. 0066-4804 10.1128/AAC.00062-08 |
url |
https://www.arca.fiocruz.br/handle/icict/30811 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
American Society for Microbiology |
publisher.none.fl_str_mv |
American Society for Microbiology |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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