Theft and reception of host cell`s Sialic Acid: dynamics of Trypanosoma Cruzi Trans-sialidases and Mucin-Like molecules on Chagas´s Disease Immunomodulation

Detalhes bibliográficos
Autor(a) principal: Fonseca, Leonardo Marques da
Data de Publicação: 2019
Outros Autores: Costa, Kelli Monteiro da, Chaves, Victoria de Sousa, Lima, Célio Geraldo Freire de, Morrot, Alexandre, Previato, Lucia Mendonça, Previato, Jose Osvaldo, Lima, Leonardo Freire de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/35608
Resumo: Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Glicobiologia. Rio de Janeiro, RJ, Brasil.
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spelling Fonseca, Leonardo Marques daCosta, Kelli Monteiro daChaves, Victoria de SousaLima, Célio Geraldo Freire deMorrot, AlexandrePreviato, Lucia MendonçaPreviato, Jose OsvaldoLima, Leonardo Freire de2019-09-16T18:38:06Z2019-09-16T18:38:06Z2019FONSECA, Leonardo Marques da et al. Theft and reception of host cell´s Sialic Acid: dynamics of Trypanosoma Cruzi Trans-sialidases and Mucin-Like Moleculares on Chagas` Diesease Immunomodulation. Frontiers in Immunology, v. 10, p. 1-10, Feb. 2019.1664-3224https://www.arca.fiocruz.br/handle/icict/3560810.3389/fimmu.2019.00164engFrontiers MediaTrypanosoma cruziÁcido N-AcetilneuramínicoDoença infecciosaResposta da célula TProteína de ligação à glicinaDoença de ChagasTrypanosoma cruziTrans-sialidaseMucin-like moleculeSialic acidGlycan-binding proteinInfectious diseaseT-cell responseChagas DiseaseÁcido N-AcetilneuramínicoMucinaTheft and reception of host cell`s Sialic Acid: dynamics of Trypanosoma Cruzi Trans-sialidases and Mucin-Like molecules on Chagas´s Disease Immunomodulationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Glicobiologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Glicobiologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Glicobiologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Imunomodulação. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Laboratório de Pesquisa em Tuberculose. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Glicobiologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Glicobiologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Glicobiologia. Rio de Janeiro, RJ, Brasil.The last decades have produced a plethora of evidence on the role of glycans, from cell adhesion to signaling pathways. Much of that information pertains to their role on the immune system and their importance on the surface of many human pathogens. A clear example of this is the flagellated protozoan Trypanosoma cruzi, which displays on its surface a great variety of glycoconjugates, including O-glycosylated mucin-like glycoproteins, as well as multiple glycan-binding proteins belonging to the trans-sialidase (TS)family.Amongthelatter,differentandconcurrentlyexpressedmoleculesmaypresent or not TS activity, and are accordingly known as active (aTS) and inactive (iTS) members. Over the last thirty years, it has been well described that T. cruzi is unable to synthesize sialic acid (SIA) on its own, making use of aTS to steal the host’s SIA. Although iTS did not show enzymatic activity, it retains a substrate specificity similar to aTS (α-2,3 SIA-containing glycotopes), displaying lectinic properties. It is accepted that aTS members act as virulence factors in mammals coursing the acute phase of the T. cruzi infection. However, recent findings have demonstrated that iTS may also play a pathogenic role during T. cruzi infection, since it modulates events related to adhesion and invasion of the parasite into the host cells. Since both aTS and iTS proteins share structural substrate specificity, it might be plausible to speculate that iTS proteins are able to assuage and/or attenuate biological phenomena depending on the catalytic activity displayed by aTS members. Since SIA-containing glycotopes modulate the host immune system, it should not come as any surprise that changes in the sialylation of parasite’s mucin-like molecules, as well as host cell glycoconjugates might disrupt critical physiological events, such as the building of effective immune responses. This review aims to discuss the importance of mucin-like glycoproteins and both aTS and iTS for T. cruzi biology, as well as to present a snapshot of how disturbances in both parasite and host cellsialoglycophenotypes may facilitatethe persistence of T. cruzi in the infected mammalian host.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/35608/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAlexandreMorrot_KelliCosta_etal_IOC_2019.pdfAlexandreMorrot_KelliCosta_etal_IOC_2019.pdfapplication/pdf750155https://www.arca.fiocruz.br/bitstream/icict/35608/2/AlexandreMorrot_KelliCosta_etal_IOC_2019.pdf88c3540e90851968e68a5130864e7325MD52TEXTAlexandreMorrot_KelliCosta_etal_IOC_2019.pdf.txtAlexandreMorrot_KelliCosta_etal_IOC_2019.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Theft and reception of host cell`s Sialic Acid: dynamics of Trypanosoma Cruzi Trans-sialidases and Mucin-Like molecules on Chagas´s Disease Immunomodulation
title Theft and reception of host cell`s Sialic Acid: dynamics of Trypanosoma Cruzi Trans-sialidases and Mucin-Like molecules on Chagas´s Disease Immunomodulation
spellingShingle Theft and reception of host cell`s Sialic Acid: dynamics of Trypanosoma Cruzi Trans-sialidases and Mucin-Like molecules on Chagas´s Disease Immunomodulation
Fonseca, Leonardo Marques da
Trypanosoma cruzi
Ácido N-Acetilneuramínico
Doença infecciosa
Resposta da célula T
Proteína de ligação à glicina
Doença de Chagas
Trypanosoma cruzi
Trans-sialidase
Mucin-like molecule
Sialic acid
Glycan-binding protein
Infectious disease
T-cell response
Chagas Disease
Ácido N-Acetilneuramínico
Mucina
title_short Theft and reception of host cell`s Sialic Acid: dynamics of Trypanosoma Cruzi Trans-sialidases and Mucin-Like molecules on Chagas´s Disease Immunomodulation
title_full Theft and reception of host cell`s Sialic Acid: dynamics of Trypanosoma Cruzi Trans-sialidases and Mucin-Like molecules on Chagas´s Disease Immunomodulation
title_fullStr Theft and reception of host cell`s Sialic Acid: dynamics of Trypanosoma Cruzi Trans-sialidases and Mucin-Like molecules on Chagas´s Disease Immunomodulation
title_full_unstemmed Theft and reception of host cell`s Sialic Acid: dynamics of Trypanosoma Cruzi Trans-sialidases and Mucin-Like molecules on Chagas´s Disease Immunomodulation
title_sort Theft and reception of host cell`s Sialic Acid: dynamics of Trypanosoma Cruzi Trans-sialidases and Mucin-Like molecules on Chagas´s Disease Immunomodulation
author Fonseca, Leonardo Marques da
author_facet Fonseca, Leonardo Marques da
Costa, Kelli Monteiro da
Chaves, Victoria de Sousa
Lima, Célio Geraldo Freire de
Morrot, Alexandre
Previato, Lucia Mendonça
Previato, Jose Osvaldo
Lima, Leonardo Freire de
author_role author
author2 Costa, Kelli Monteiro da
Chaves, Victoria de Sousa
Lima, Célio Geraldo Freire de
Morrot, Alexandre
Previato, Lucia Mendonça
Previato, Jose Osvaldo
Lima, Leonardo Freire de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fonseca, Leonardo Marques da
Costa, Kelli Monteiro da
Chaves, Victoria de Sousa
Lima, Célio Geraldo Freire de
Morrot, Alexandre
Previato, Lucia Mendonça
Previato, Jose Osvaldo
Lima, Leonardo Freire de
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Ácido N-Acetilneuramínico
Doença infecciosa
Resposta da célula T
Proteína de ligação à glicina
Doença de Chagas
topic Trypanosoma cruzi
Ácido N-Acetilneuramínico
Doença infecciosa
Resposta da célula T
Proteína de ligação à glicina
Doença de Chagas
Trypanosoma cruzi
Trans-sialidase
Mucin-like molecule
Sialic acid
Glycan-binding protein
Infectious disease
T-cell response
Chagas Disease
Ácido N-Acetilneuramínico
Mucina
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Trans-sialidase
Mucin-like molecule
Sialic acid
Glycan-binding protein
Infectious disease
T-cell response
Chagas Disease
dc.subject.decs.pt_BR.fl_str_mv Ácido N-Acetilneuramínico
Mucina
description Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Glicobiologia. Rio de Janeiro, RJ, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-09-16T18:38:06Z
dc.date.available.fl_str_mv 2019-09-16T18:38:06Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FONSECA, Leonardo Marques da et al. Theft and reception of host cell´s Sialic Acid: dynamics of Trypanosoma Cruzi Trans-sialidases and Mucin-Like Moleculares on Chagas` Diesease Immunomodulation. Frontiers in Immunology, v. 10, p. 1-10, Feb. 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/35608
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2019.00164
identifier_str_mv FONSECA, Leonardo Marques da et al. Theft and reception of host cell´s Sialic Acid: dynamics of Trypanosoma Cruzi Trans-sialidases and Mucin-Like Moleculares on Chagas` Diesease Immunomodulation. Frontiers in Immunology, v. 10, p. 1-10, Feb. 2019.
1664-3224
10.3389/fimmu.2019.00164
url https://www.arca.fiocruz.br/handle/icict/35608
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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