Non-alcoholic fatty liver disease and insulin resistance: importance of risk factors and histological spectrum.

Detalhes bibliográficos
Autor(a) principal: Siqueira, Ana Cristina Guidorizzi de
Data de Publicação: 2005
Outros Autores: Cotrim, Helma Pinchemel, Rocha, Raquel, Carvalho, Fernando Martins, Freitas, Luiz Antonio Rodrigues de, Barreto, Danyella, Gouveia, Leandro, Landeiro, Luciana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7880
Resumo: Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
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spelling Siqueira, Ana Cristina Guidorizzi deCotrim, Helma PinchemelRocha, RaquelCarvalho, Fernando MartinsFreitas, Luiz Antonio Rodrigues deBarreto, DanyellaGouveia, LeandroLandeiro, Luciana2014-07-08T14:23:37Z2014-07-08T14:23:37Z2005GUIDORIZZI DE SIQUEIRA, A. C. et al. Non-alcoholic fatty liver disease and insulin resistance: importance of risk factors and histological spectrum. European Journal of Gastroenterology & Hepatology, v. 17, n. 8, p. 837-841, 2005.0954-691Xhttps://www.arca.fiocruz.br/handle/icict/7880engLippincott Williams & WilkinsNon-alcoholic fatty liver disease and insulin resistance: importance of risk factors and histological spectrum.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, BrasilBACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has been associated with several metabolic conditions (MC) and secondary causes, but the relationship between insulin resistance (IR) and the underlying aetiology of NAFLD has not been extensively explored. OBJECTIVE: To determine the frequency of IR among NAFLD patients and to describe IR according to risk factors and histological findings of the disease. METHODOLOGY: A case-series study of 64 patients with clinical and histological diagnosis of NAFLD. IR was calculated by homeostasis model assessment (HOMA) and IR was considered when HOMA > or = 3. Histological grades of NAFLD were: stage 1, steatosis isolated; stage 2, steatosis and inflammation; stage 3, steatosis and ballooning degeneration; stage 4, steatosis and fibrosis and/or Mallory bodies. Fibrosis was graded 0-4 (cirrhosis). RESULTS: IR was found in 21 (33%) patients. Among those with IR, 16 patients (76%) had associated MC and five patients (24%) had exposure to petrochemicals. The mean value of HOMA varied from 3.5 in NAFLD associated with MC to 1.6 in patients with exposure to petrochemicals (P < 0.03). Waist circumference was the metabolic factor most strongly associated with IR (P < 0.005). Steatohepatitis (NASH) was observed in 54 (84.3%) cases. The HOMA mean value was significantly higher in patients with advanced fibrosis. CONCLUSIONS: IR occurred in 33% of the NAFLD patients, being more frequent among those with MC than among those with exposure to petrochemicals. The presence of IR in cases with advanced fibrosis suggests that it may influence the prognosis of NAFLD.Non-alcoholic fatty liver diseaseNon-alcoholic steatohepatitisInsulin resistanceFígado Gorduroso/fisiopatologiaResistência à Insulina/fisiologiaAdultoDoença CrônicaFígado Gorduroso/sangueFígado Gorduroso/patologiaFemininoHumanosCirrose Hepática/sangueCirrose Hepática/patologiaCirrose Hepática/fisiopatologiaMasculinoSíndrome X Metabólica/sangueSíndrome X Metabólica/patologiaSíndrome X Metabólica/fisiopatologiaMeia-IdadeFatores de Riscoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSiqueira ACG Non-alcogolic....pdfSiqueira ACG Non-alcogolic....pdfapplication/pdf83109https://www.arca.fiocruz.br/bitstream/icict/7880/1/Siqueira%20ACG%20Non-alcogolic....pdf5b111d26fb2bf982f064436a2567a53bMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7880/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTSiqueira ACG Non-alcogolic....pdf.txtSiqueira ACG Non-alcogolic....pdf.txtExtracted texttext/plain26241https://www.arca.fiocruz.br/bitstream/icict/7880/3/Siqueira%20ACG%20Non-alcogolic....pdf.txt6945e343f6c65ae03d94ef1d353c55c5MD53icict/78802023-03-15 14:33:14.839oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:14Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Non-alcoholic fatty liver disease and insulin resistance: importance of risk factors and histological spectrum.
title Non-alcoholic fatty liver disease and insulin resistance: importance of risk factors and histological spectrum.
spellingShingle Non-alcoholic fatty liver disease and insulin resistance: importance of risk factors and histological spectrum.
Siqueira, Ana Cristina Guidorizzi de
Non-alcoholic fatty liver disease
Non-alcoholic steatohepatitis
Insulin resistance
Fígado Gorduroso/fisiopatologia
Resistência à Insulina/fisiologia
Adulto
Doença Crônica
Fígado Gorduroso/sangue
Fígado Gorduroso/patologia
Feminino
Humanos
Cirrose Hepática/sangue
Cirrose Hepática/patologia
Cirrose Hepática/fisiopatologia
Masculino
Síndrome X Metabólica/sangue
Síndrome X Metabólica/patologia
Síndrome X Metabólica/fisiopatologia
Meia-Idade
Fatores de Risco
title_short Non-alcoholic fatty liver disease and insulin resistance: importance of risk factors and histological spectrum.
title_full Non-alcoholic fatty liver disease and insulin resistance: importance of risk factors and histological spectrum.
title_fullStr Non-alcoholic fatty liver disease and insulin resistance: importance of risk factors and histological spectrum.
title_full_unstemmed Non-alcoholic fatty liver disease and insulin resistance: importance of risk factors and histological spectrum.
title_sort Non-alcoholic fatty liver disease and insulin resistance: importance of risk factors and histological spectrum.
author Siqueira, Ana Cristina Guidorizzi de
author_facet Siqueira, Ana Cristina Guidorizzi de
Cotrim, Helma Pinchemel
Rocha, Raquel
Carvalho, Fernando Martins
Freitas, Luiz Antonio Rodrigues de
Barreto, Danyella
Gouveia, Leandro
Landeiro, Luciana
author_role author
author2 Cotrim, Helma Pinchemel
Rocha, Raquel
Carvalho, Fernando Martins
Freitas, Luiz Antonio Rodrigues de
Barreto, Danyella
Gouveia, Leandro
Landeiro, Luciana
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Siqueira, Ana Cristina Guidorizzi de
Cotrim, Helma Pinchemel
Rocha, Raquel
Carvalho, Fernando Martins
Freitas, Luiz Antonio Rodrigues de
Barreto, Danyella
Gouveia, Leandro
Landeiro, Luciana
dc.subject.en.pt_BR.fl_str_mv Non-alcoholic fatty liver disease
Non-alcoholic steatohepatitis
Insulin resistance
topic Non-alcoholic fatty liver disease
Non-alcoholic steatohepatitis
Insulin resistance
Fígado Gorduroso/fisiopatologia
Resistência à Insulina/fisiologia
Adulto
Doença Crônica
Fígado Gorduroso/sangue
Fígado Gorduroso/patologia
Feminino
Humanos
Cirrose Hepática/sangue
Cirrose Hepática/patologia
Cirrose Hepática/fisiopatologia
Masculino
Síndrome X Metabólica/sangue
Síndrome X Metabólica/patologia
Síndrome X Metabólica/fisiopatologia
Meia-Idade
Fatores de Risco
dc.subject.decs.pt_BR.fl_str_mv Fígado Gorduroso/fisiopatologia
Resistência à Insulina/fisiologia
Adulto
Doença Crônica
Fígado Gorduroso/sangue
Fígado Gorduroso/patologia
Feminino
Humanos
Cirrose Hepática/sangue
Cirrose Hepática/patologia
Cirrose Hepática/fisiopatologia
Masculino
Síndrome X Metabólica/sangue
Síndrome X Metabólica/patologia
Síndrome X Metabólica/fisiopatologia
Meia-Idade
Fatores de Risco
description Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2014-07-08T14:23:37Z
dc.date.available.fl_str_mv 2014-07-08T14:23:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GUIDORIZZI DE SIQUEIRA, A. C. et al. Non-alcoholic fatty liver disease and insulin resistance: importance of risk factors and histological spectrum. European Journal of Gastroenterology & Hepatology, v. 17, n. 8, p. 837-841, 2005.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7880
dc.identifier.issn.none.fl_str_mv 0954-691X
identifier_str_mv GUIDORIZZI DE SIQUEIRA, A. C. et al. Non-alcoholic fatty liver disease and insulin resistance: importance of risk factors and histological spectrum. European Journal of Gastroenterology & Hepatology, v. 17, n. 8, p. 837-841, 2005.
0954-691X
url https://www.arca.fiocruz.br/handle/icict/7880
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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