Leprosy incidence and risk estimates in a 33‑year contact cohort of leprosy patients

Bibliographic Details
Main Author: Hacker, Mariana Andrea
Publication Date: 2021
Other Authors: Sales, Anna Maria, Duppre, Nádia Cristina, Sarno, Euzenir Nunes, Moraes, Milton Ozório
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/46995
Summary: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
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spelling Hacker, Mariana AndreaSales, Anna MariaDuppre, Nádia CristinaSarno, Euzenir NunesMoraes, Milton Ozório2021-05-01T14:09:19Z2021-05-01T14:09:19Z2021HACKER, Mariana Andrea et al. Leprosy incidence and risk estimates in a 33-year contact cohort of leprosy patients. Scientifc Reports, v. 11, n. 1947, Jan. 2021.2045-2322https://www.arca.fiocruz.br/handle/icict/4699510.1038/s41598-021-81643-4engNature ResearchHanseníasePacientesEstimativa de riscoLeprosyRisk estimatesPatientsLeprosy incidence and risk estimates in a 33‑year contact cohort of leprosy patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Reduction in incidence has been associated with the introduction of novel approaches, like chemo/immune-prophylaxis. Incidence determined through follow-up cohort studies can evaluate the implementation of these innovative policies towards control and prevention. We have assessed the incidence in our contacts cohort over past 33 years, considering the effect of demographic and clinical variables. Survival analysis was used to estimate the risk of leprosy. A total of 9024 contacts were evaluated, of which 192 developed leprosy, resulting in an overall incidence of 1.4/1000 person-years. The multivariate analysis showed that the major risk factors were (i) contact from MB index cases and (ii) consanguinity (iii) intra household contact. Lower risk was detected for contacts with BCG scar who were revaccinated. There was a significant decrease in accumulated risk between the 2011–2019 period compared with 1987, probably linked to the improvement in laboratory tools to monitor contacts, thereby providing early diagnosis of contacts at intake and reduction of transmission. Our findings suggest that a combination of contact surveillance and tracing, adequate neurodermatological examination, and availability of molecular tools is highly effective in supporting early diagnosis, while a second dose of the BCG vaccination can exert extra protection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/46995/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMarianaHacker_MiltonOMoraes_etal_IOC_2021.pdfMarianaHacker_MiltonOMoraes_etal_IOC_2021.pdfapplication/pdf911862https://www.arca.fiocruz.br/bitstream/icict/46995/2/MarianaHacker_MiltonOMoraes_etal_IOC_2021.pdfd4ecc63a3e73e181d8b802147cda6fd6MD52TEXTMarianaHacker_MiltonOMoraes_etal_IOC_2021.pdf.txtMarianaHacker_MiltonOMoraes_etal_IOC_2021.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Leprosy incidence and risk estimates in a 33‑year contact cohort of leprosy patients
title Leprosy incidence and risk estimates in a 33‑year contact cohort of leprosy patients
spellingShingle Leprosy incidence and risk estimates in a 33‑year contact cohort of leprosy patients
Hacker, Mariana Andrea
Hanseníase
Pacientes
Estimativa de risco
Leprosy
Risk estimates
Patients
title_short Leprosy incidence and risk estimates in a 33‑year contact cohort of leprosy patients
title_full Leprosy incidence and risk estimates in a 33‑year contact cohort of leprosy patients
title_fullStr Leprosy incidence and risk estimates in a 33‑year contact cohort of leprosy patients
title_full_unstemmed Leprosy incidence and risk estimates in a 33‑year contact cohort of leprosy patients
title_sort Leprosy incidence and risk estimates in a 33‑year contact cohort of leprosy patients
author Hacker, Mariana Andrea
author_facet Hacker, Mariana Andrea
Sales, Anna Maria
Duppre, Nádia Cristina
Sarno, Euzenir Nunes
Moraes, Milton Ozório
author_role author
author2 Sales, Anna Maria
Duppre, Nádia Cristina
Sarno, Euzenir Nunes
Moraes, Milton Ozório
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Hacker, Mariana Andrea
Sales, Anna Maria
Duppre, Nádia Cristina
Sarno, Euzenir Nunes
Moraes, Milton Ozório
dc.subject.other.pt_BR.fl_str_mv Hanseníase
Pacientes
Estimativa de risco
topic Hanseníase
Pacientes
Estimativa de risco
Leprosy
Risk estimates
Patients
dc.subject.en.pt_BR.fl_str_mv Leprosy
Risk estimates
Patients
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-05-01T14:09:19Z
dc.date.available.fl_str_mv 2021-05-01T14:09:19Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv HACKER, Mariana Andrea et al. Leprosy incidence and risk estimates in a 33-year contact cohort of leprosy patients. Scientifc Reports, v. 11, n. 1947, Jan. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46995
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-021-81643-4
identifier_str_mv HACKER, Mariana Andrea et al. Leprosy incidence and risk estimates in a 33-year contact cohort of leprosy patients. Scientifc Reports, v. 11, n. 1947, Jan. 2021.
2045-2322
10.1038/s41598-021-81643-4
url https://www.arca.fiocruz.br/handle/icict/46995
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/46995/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/46995/2/MarianaHacker_MiltonOMoraes_etal_IOC_2021.pdf
https://www.arca.fiocruz.br/bitstream/icict/46995/3/MarianaHacker_MiltonOMoraes_etal_IOC_2021.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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