High HIV-1 Genetic Diversity in Patients from Northern Brazil

Detalhes bibliográficos
Autor(a) principal: Costa, Carolina Marinho da
Data de Publicação: 2016
Outros Autores: Oliveira, Cintia Mara Costa de, Melo, Yonne Francis Chehuan de, Delatorre, Edson, Bello, Gonzalo, Couto-Fernandez, Jose Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/18641
Resumo: Pré-print do artigo enviado por um dos autores
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spelling Costa, Carolina Marinho daOliveira, Cintia Mara Costa deMelo, Yonne Francis Chehuan deDelatorre, EdsonBello, GonzaloCouto-Fernandez, Jose Carlos2017-04-25T11:33:28Z2017-04-25T11:33:28Z2016COSTA, Carolina Marinho da; et al. High HIV-1 Genetic Diversity in Patients from Northern Brazil. AIDS Research and Human Retroviruses, v.32, n.9, p.918-922, Sept. 2016.0889-2229https://www.arca.fiocruz.br/handle/icict/186411931-8405Pré-print do artigo enviado por um dos autoresSecretaria de Estado da Saúde do Amazonas. Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Laboratório de Genotipagem de HIV. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, Brasil.Secretaria de Estado da Saúde do Amazonas. Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Laboratório de Genotipagem de HIV. Manaus, AM, Brasil.Secretaria de Estado da Saúde do Amazonas. Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Laboratório de Genotipagem de HIV. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ. Brasil.The HIV-1 epidemic in Brazil is driven by subtypes B, F1, and C and recombinants forms among those subtypes. The distribution of HIV-1 subtypes, however, may vary across different Brazilian regions and the molecular epidemiologic profile in Northern Brazil remains poorly explored. HIV-1 pol sequences were obtained from 305 patients failing antiretroviral therapy followed at outpatient clinics from five Northern Brazilian states. The most prevalent HIV-1 clade observed in the Northern Brazilian region was subtype B (81%), followed by BF1 recombinants (10%), subtype F1 (4%), subtype C (3%), BC recombinants (2%), and BU recombinants (1%). Although HIV-1 subtype B was the predominant HIV-1 clade in Northern Brazil, its prevalence greatly varies among different states, ranging from 63% in Rondônia to 92% in Acre. Among the 37 HIV-1 recombinant sequences detected in the Northern Brazilian region, nine (24%) displayed a unique recombinant form structure, five (14%) a CRF28/29_BF-like structure, and four (11%) a CRF31_BC-like structure. Two other BF1 recombinant patterns were identified in 16 (43%) and three (8%) samples that may correspond to two potentially new CRFs_BF characteristic of the Northern region. This study reveals that despite the low spatial connectivity with other Brazilian regions, the genetic complexity of the HIV-1 epidemic in Northern Brazil is very high and that the molecular epidemiologic pattern may vary across different northern states, reflecting a complex epidemic with multiple independent viral introductions into this Brazilian region.engMary Ann LiebertHIVsubtiposRegião NorteBrasilHIVNorthern regionsubtypesBrazilHigh HIV-1 Genetic Diversity in Patients from Northern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv High HIV-1 Genetic Diversity in Patients from Northern Brazil
title High HIV-1 Genetic Diversity in Patients from Northern Brazil
spellingShingle High HIV-1 Genetic Diversity in Patients from Northern Brazil
Costa, Carolina Marinho da
HIV
subtipos
Região Norte
Brasil
HIV
Northern region
subtypes
Brazil
title_short High HIV-1 Genetic Diversity in Patients from Northern Brazil
title_full High HIV-1 Genetic Diversity in Patients from Northern Brazil
title_fullStr High HIV-1 Genetic Diversity in Patients from Northern Brazil
title_full_unstemmed High HIV-1 Genetic Diversity in Patients from Northern Brazil
title_sort High HIV-1 Genetic Diversity in Patients from Northern Brazil
author Costa, Carolina Marinho da
author_facet Costa, Carolina Marinho da
Oliveira, Cintia Mara Costa de
Melo, Yonne Francis Chehuan de
Delatorre, Edson
Bello, Gonzalo
Couto-Fernandez, Jose Carlos
author_role author
author2 Oliveira, Cintia Mara Costa de
Melo, Yonne Francis Chehuan de
Delatorre, Edson
Bello, Gonzalo
Couto-Fernandez, Jose Carlos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Costa, Carolina Marinho da
Oliveira, Cintia Mara Costa de
Melo, Yonne Francis Chehuan de
Delatorre, Edson
Bello, Gonzalo
Couto-Fernandez, Jose Carlos
dc.subject.other.pt_BR.fl_str_mv HIV
subtipos
Região Norte
Brasil
topic HIV
subtipos
Região Norte
Brasil
HIV
Northern region
subtypes
Brazil
dc.subject.en.pt_BR.fl_str_mv HIV
Northern region
subtypes
Brazil
description Pré-print do artigo enviado por um dos autores
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-04-25T11:33:28Z
dc.date.available.fl_str_mv 2017-04-25T11:33:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COSTA, Carolina Marinho da; et al. High HIV-1 Genetic Diversity in Patients from Northern Brazil. AIDS Research and Human Retroviruses, v.32, n.9, p.918-922, Sept. 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/18641
dc.identifier.issn.pt_BR.fl_str_mv 0889-2229
dc.identifier.eissn.none.fl_str_mv 1931-8405
identifier_str_mv COSTA, Carolina Marinho da; et al. High HIV-1 Genetic Diversity in Patients from Northern Brazil. AIDS Research and Human Retroviruses, v.32, n.9, p.918-922, Sept. 2016.
0889-2229
1931-8405
url https://www.arca.fiocruz.br/handle/icict/18641
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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