The association of infection and clinical severity in sickle cell anaemia patients.

Detalhes bibliográficos
Autor(a) principal: Moura Neto, José Pereira de
Data de Publicação: 2011
Outros Autores: Lyra, Isa Menezes, Reis, Mitermayer Galvão dos, Gonçalves, Marilda de Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7942
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Analises Clinicas e Toxicologicas. Salvador, BA, Brasil
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spelling Moura Neto, José Pereira deLyra, Isa MenezesReis, Mitermayer Galvão dosGonçalves, Marilda de Souza2014-07-14T13:28:08Z2014-07-14T13:28:08Z2011MOURA NETO, J. P. et al. The association of infection and clinical severity in sickle cell anaemia patients.Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 105, n. 3, p. 121-126, 2011.1878-3503https://www.arca.fiocruz.br/handle/icict/794210.1016/j.trstmh.2010.11.007engElsevierAnemia falciformeVirus T-limfotropico humanoHepatiteInfecçãoSickle cell anaemiaInfectionHuman T-lymphotropic virusHepatitisAnemia Falciforme/epidemiologiaInfecções por HIV/epidemiologiaInfecções por HTLV-I/epidemiologiaHepatite B/epidemiologiaHepatite C/epidemiologiaSífilis/epidemiologiaAnemia Falciforme/complicaçõesTransfusão de Sangue/efeitos adversosBrasil/epidemiologiaFemininoHumanosMasculinoPrevalênciaEstudos RetrospectivosFatores de RiscoÍndice de Gravidade de DoençaAdulto JovemThe association of infection and clinical severity in sickle cell anaemia patients.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Analises Clinicas e Toxicologicas. Salvador, BA, BrasilFundacao de Hematologia e Hemoterapia do Estado da Bahia (HEMOBA). Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Analises Clinicas e Toxicologicas. Salvador, BA, BrasilSickle cell anaemia (SCA) patients have a high risk of infection. We retrospectively investigated the prevalence of infection among SCA patients from Bahia, Brazil. A total of 1415 SCA patients were studied between 1995 and 2009: 190 (13.4%) had hepatitis C virus (HCV), 67 (4.7%) had human T-lymphotropic virus type I (HTLV-I), 44 (3.1%) had hepatitis B virus (HBV), 40 (2.8%) had Chagas’ disease, 11 (0.8%) had human immunodeficiency virus (HIV), and 5 (0.4%) had syphilis. Patients with HCV infection had a higher risk of hospitalisation (OR = 1.52, 95% Cl: 1.07-2.17, P = 0.020), bone disorders (OR = 1.94, 95% Cl: 1.15-3.27, P = 0.011), stroke (OR = 2.17, 95% Cl: 1.12–4.14, P = 0.017), painful crisis (OR = 1.61, 95% Cl: 1.17-2.22, P = 0.004) and leg ulcers (OR = 1.61, 95% Cl: 1.04-3.03, P = 0.031). Patients with HBV infection had a higher risk for bone disorders (OR = 4.90, 95% Cl: 2.08-11.54, P < .010), stroke (OR = 3.01, 95% Cl: 1.29-6.04, P = 0.007), painful crisis (OR = 3.51, 95% Cl: 1.62-7.63, P < 0.001), acute chest syndrome (ACS) (OR = 2.66, 95% Cl: 1.34-5.28, P = 0.004), leg ulcers (OR = 6.60, 95% Cl: 3.37-12.91, P < .001) and vaso-occlusive crisis (OR = 6.34, 95% Cl: 1.96- 20.66, P < 0.001). Patients with HTLV-I infection had a high risk for bone disorders (OR = 2.94, 95% Cl: 1.28-6.74, P = 0.011), respiratory failure (OR = 2.66, 95% Cl: 1.26-5.51, P = 0.012), leg ulcers (OR = 3.27, 95% Cl: 1.69-6.11, P < .001), painful crisis (OR = 1.82, 95% Cl: 1.07-3.13, P = 0.025) and ACS (OR = 1.85, 95% Cl: 1.10-3.41, P < .047). SCA patients with HCV infection had increased triglycerides and low-density lipoprotein cholesterol (P = 0.036; P = 0.027), iron serum (P = 0.016) and ferritin (P = 0.007). These results reveal important roles for these infections in SCA patients’ clinical outcomes, and studies are warranted to determine the mechanisms utilised by these agents and their involvement in disease severity.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMoura Neto JP The association....pdfMoura Neto JP The association....pdfapplication/pdf140540https://www.arca.fiocruz.br/bitstream/icict/7942/1/Moura%20Neto%20JP%20The%20association....pdfc0f89759b021d2ddc43c1db26d5e4269MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7942/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTMoura Neto JP The association....pdf.txtMoura Neto JP The association....pdf.txtExtracted texttext/plain28992https://www.arca.fiocruz.br/bitstream/icict/7942/3/Moura%20Neto%20JP%20The%20association....pdf.txt71606b7f0003a4df97467e7d1cfc3bc8MD53icict/79422023-03-15 14:32:55.896oai:www.arca.fiocruz.br:icict/7942TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:55Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The association of infection and clinical severity in sickle cell anaemia patients.
title The association of infection and clinical severity in sickle cell anaemia patients.
spellingShingle The association of infection and clinical severity in sickle cell anaemia patients.
Moura Neto, José Pereira de
Anemia falciforme
Virus T-limfotropico humano
Hepatite
Infecção
Sickle cell anaemia
Infection
Human T-lymphotropic virus
Hepatitis
Anemia Falciforme/epidemiologia
Infecções por HIV/epidemiologia
Infecções por HTLV-I/epidemiologia
Hepatite B/epidemiologia
Hepatite C/epidemiologia
Sífilis/epidemiologia
Anemia Falciforme/complicações
Transfusão de Sangue/efeitos adversos
Brasil/epidemiologia
Feminino
Humanos
Masculino
Prevalência
Estudos Retrospectivos
Fatores de Risco
Índice de Gravidade de Doença
Adulto Jovem
title_short The association of infection and clinical severity in sickle cell anaemia patients.
title_full The association of infection and clinical severity in sickle cell anaemia patients.
title_fullStr The association of infection and clinical severity in sickle cell anaemia patients.
title_full_unstemmed The association of infection and clinical severity in sickle cell anaemia patients.
title_sort The association of infection and clinical severity in sickle cell anaemia patients.
author Moura Neto, José Pereira de
author_facet Moura Neto, José Pereira de
Lyra, Isa Menezes
Reis, Mitermayer Galvão dos
Gonçalves, Marilda de Souza
author_role author
author2 Lyra, Isa Menezes
Reis, Mitermayer Galvão dos
Gonçalves, Marilda de Souza
author2_role author
author
author
dc.contributor.author.fl_str_mv Moura Neto, José Pereira de
Lyra, Isa Menezes
Reis, Mitermayer Galvão dos
Gonçalves, Marilda de Souza
dc.subject.other.pt_BR.fl_str_mv Anemia falciforme
Virus T-limfotropico humano
Hepatite
Infecção
topic Anemia falciforme
Virus T-limfotropico humano
Hepatite
Infecção
Sickle cell anaemia
Infection
Human T-lymphotropic virus
Hepatitis
Anemia Falciforme/epidemiologia
Infecções por HIV/epidemiologia
Infecções por HTLV-I/epidemiologia
Hepatite B/epidemiologia
Hepatite C/epidemiologia
Sífilis/epidemiologia
Anemia Falciforme/complicações
Transfusão de Sangue/efeitos adversos
Brasil/epidemiologia
Feminino
Humanos
Masculino
Prevalência
Estudos Retrospectivos
Fatores de Risco
Índice de Gravidade de Doença
Adulto Jovem
dc.subject.en.pt_BR.fl_str_mv Sickle cell anaemia
Infection
Human T-lymphotropic virus
Hepatitis
dc.subject.decs.pt_BR.fl_str_mv Anemia Falciforme/epidemiologia
Infecções por HIV/epidemiologia
Infecções por HTLV-I/epidemiologia
Hepatite B/epidemiologia
Hepatite C/epidemiologia
Sífilis/epidemiologia
Anemia Falciforme/complicações
Transfusão de Sangue/efeitos adversos
Brasil/epidemiologia
Feminino
Humanos
Masculino
Prevalência
Estudos Retrospectivos
Fatores de Risco
Índice de Gravidade de Doença
Adulto Jovem
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Analises Clinicas e Toxicologicas. Salvador, BA, Brasil
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-07-14T13:28:08Z
dc.date.available.fl_str_mv 2014-07-14T13:28:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MOURA NETO, J. P. et al. The association of infection and clinical severity in sickle cell anaemia patients.Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 105, n. 3, p. 121-126, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7942
dc.identifier.issn.none.fl_str_mv 1878-3503
dc.identifier.doi.none.fl_str_mv 10.1016/j.trstmh.2010.11.007
identifier_str_mv MOURA NETO, J. P. et al. The association of infection and clinical severity in sickle cell anaemia patients.Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 105, n. 3, p. 121-126, 2011.
1878-3503
10.1016/j.trstmh.2010.11.007
url https://www.arca.fiocruz.br/handle/icict/7942
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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