The association of infection and clinical severity in sickle cell anaemia patients

Detalhes bibliográficos
Autor(a) principal: Moura Neto, José Pereira de
Data de Publicação: 2011
Outros Autores: Lyra, Isa Menezes, Reis, Mitermayer Galvão dos, Goncalvesa, Marilda Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5239
Resumo: p.121–126
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spelling Moura Neto, José Pereira deLyra, Isa MenezesReis, Mitermayer Galvão dosGoncalvesa, Marilda SouzaMoura Neto, José Pereira deLyra, Isa MenezesReis, Mitermayer Galvão dosGoncalvesa, Marilda Souza2012-01-24T12:26:27Z2012-01-24T12:26:27Z20110035-9203http://www.repositorio.ufba.br/ri/handle/ri/5239v. 105p.121–126Sickle cell anaemia (SCA) patients have a high risk of infection. We retrospectively investigated the prevalence of infection among SCA patients from Bahia, Brazil. A total of 1415 SCA patients were studied between 1995 and 2009: 190 (13.4%) had hepatitis C virus (HCV), 67 (4.7%) had human T-lymphotropic virus type I (HTLV-I), 44 (3.1%) had hepatitis B virus (HBV), 40 (2.8%) had Chagas’ disease, 11 (0.8%) had human immunodeficiency virus (HIV), and 5 (0.4%) had syphilis. Patients with HCV infection had a higher risk of hospitalisation (OR = 1.52, 95% Cl: 1.07-2.17, P = 0.020), bone disorders (OR = 1.94, 95% Cl: 1.15-3.27, P = 0.011), stroke (OR = 2.17, 95% Cl: 1.12–4.14, P = 0.017), painful crisis (OR = 1.61, 95% Cl: 1.17-2.22, P = 0.004) and leg ulcers (OR = 1.61, 95% Cl: 1.04-3.03, P = 0.031). Patients with HBV infection had a higher risk for bone disorders (OR = 4.90, 95% Cl: 2.08-11.54, P < .010), stroke (OR = 3.01, 95% Cl: 1.29-6.04, P = 0.007), painful crisis (OR = 3.51, 95% Cl: 1.62-7.63, P < 0.001), acute chest syndrome (ACS) (OR = 2.66, 95% Cl: 1.34-5.28, P = 0.004), leg ulcers (OR = 6.60, 95% Cl: 3.37-12.91, P < .001) and vaso-occlusive crisis (OR = 6.34, 95% Cl: 1.96-20.66, P < 0.001). Patients with HTLV-I infection had a high risk for bone disorders (OR = 2.94, 95% Cl: 1.28-6.74, P = 0.011), respiratory failure (OR = 2.66, 95% Cl: 1.26-5.51, P = 0.012), leg ulcers (OR = 3.27, 95% Cl: 1.69-6.11, P < .001), painful crisis (OR = 1.82, 95% Cl: 1.07-3.13, P = 0.025) and ACS (OR = 1.85, 95% Cl: 1.10-3.41, P < .047). SCA patients with HCV infection had increased triglycerides and low-density lipoprotein cholesterol (P = 0.036; P = 0.027), iron serum (P = 0.016) and ferritin (P = 0.007). These results reveal important roles for these infections in SCA patients’ clinical outcomes, and studies are warranted to determine the mechanisms utilised by these agents and their involvement in disease severity.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2012-01-24T12:26:27Z No. of bitstreams: 1 S0035920310002567-main.pdf: 146834 bytes, checksum: df3251df457b6db11a36cd8cbafb073f (MD5)Made available in DSpace on 2012-01-24T12:26:27Z (GMT). No. of bitstreams: 1 S0035920310002567-main.pdf: 146834 bytes, checksum: df3251df457b6db11a36cd8cbafb073f (MD5) Previous issue date: 2011Sickle cell anaemiainfectionhuman T-lymphotropic virushepatitisThe association of infection and clinical severity in sickle cell anaemia patientsTransactions of the Royal Society of Tropical Medicine and Hygieneinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALS0035920310002567-main.pdfS0035920310002567-main.pdfapplication/pdf146834https://repositorio.ufba.br/bitstream/ri/5239/1/S0035920310002567-main.pdfdf3251df457b6db11a36cd8cbafb073fMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5239/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTS0035920310002567-main.pdf.txtS0035920310002567-main.pdf.txtExtracted texttext/plain28199https://repositorio.ufba.br/bitstream/ri/5239/3/S0035920310002567-main.pdf.txta91347451154b8bcc9c636ae298cbcf4MD53ri/52392022-07-05 14:03:12.149oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:12Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv The association of infection and clinical severity in sickle cell anaemia patients
dc.title.alternative.pt_BR.fl_str_mv Transactions of the Royal Society of Tropical Medicine and Hygiene
title The association of infection and clinical severity in sickle cell anaemia patients
spellingShingle The association of infection and clinical severity in sickle cell anaemia patients
Moura Neto, José Pereira de
Sickle cell anaemia
infection
human T-lymphotropic virus
hepatitis
title_short The association of infection and clinical severity in sickle cell anaemia patients
title_full The association of infection and clinical severity in sickle cell anaemia patients
title_fullStr The association of infection and clinical severity in sickle cell anaemia patients
title_full_unstemmed The association of infection and clinical severity in sickle cell anaemia patients
title_sort The association of infection and clinical severity in sickle cell anaemia patients
author Moura Neto, José Pereira de
author_facet Moura Neto, José Pereira de
Lyra, Isa Menezes
Reis, Mitermayer Galvão dos
Goncalvesa, Marilda Souza
author_role author
author2 Lyra, Isa Menezes
Reis, Mitermayer Galvão dos
Goncalvesa, Marilda Souza
author2_role author
author
author
dc.contributor.author.fl_str_mv Moura Neto, José Pereira de
Lyra, Isa Menezes
Reis, Mitermayer Galvão dos
Goncalvesa, Marilda Souza
Moura Neto, José Pereira de
Lyra, Isa Menezes
Reis, Mitermayer Galvão dos
Goncalvesa, Marilda Souza
dc.subject.por.fl_str_mv Sickle cell anaemia
infection
human T-lymphotropic virus
hepatitis
topic Sickle cell anaemia
infection
human T-lymphotropic virus
hepatitis
description p.121–126
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2012-01-24T12:26:27Z
dc.date.available.fl_str_mv 2012-01-24T12:26:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5239
dc.identifier.issn.none.fl_str_mv 0035-9203
dc.identifier.number.pt_BR.fl_str_mv v. 105
identifier_str_mv 0035-9203
v. 105
url http://www.repositorio.ufba.br/ri/handle/ri/5239
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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