Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4

Detalhes bibliográficos
Autor(a) principal: Andrade, Warrison A.
Data de Publicação: 2016
Outros Autores: Agarwal, Sarika, Mo, Shunyan, Shaffer, Scott A., Dillard, Joseph P., Schmidt, Tobias, Hornung, Veit, Kurt-Jones, Evelyn A., Golenbock, Douglas T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/18431
Resumo: University of Massachusetts Medical School. Division of Infectious Diseases. Worcester, MA, USA/University of Massachusetts Medical School. Department of Medicine. Program in Innate Immunity. Worcester, MA, USA
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spelling Andrade, Warrison A.Agarwal, SarikaMo, ShunyanShaffer, Scott A.Dillard, Joseph P.Schmidt, TobiasHornung, VeitKurt-Jones, Evelyn A.Golenbock, Douglas T.2017-04-12T18:42:07Z2017-04-12T18:42:07Z2016ANDRADE, Warrison A et al. Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4. Cell Reports, v. 15, n. 11, p. 2438 – 2448, 20162211-1247https://www.arca.fiocruz.br/handle/icict/1843110.1016/j.celrep.2016.05.030.engCell PressNeisseria gonorrhoeaesistema imune inatotype I interferoncGASSTINGTLR4Neisseria gonorrhoeaeType I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Massachusetts Medical School. Division of Infectious Diseases. Worcester, MA, USA/University of Massachusetts Medical School. Department of Medicine. Program in Innate Immunity. Worcester, MA, USAUniversity of Massachusetts Medical School. Division of Infectious Diseases. Worcester, MA, USAUniversity of Massachusetts Medical School. Proteomics and Mass Spectrometry Facility. Worcester, MA, USA/University of Massachusetts Medical School. Department of Biochemistry and Molecular Pharmacology. Worcester, MA, USAUniversity of Massachusetts Medical School. Proteomics and Mass Spectrometry Facility. Worcester, MA, USA/University of Massachusetts Medical School. Department of Biochemistry and Molecular Pharmacology. Worcester, MA, USAUniversity of Wisconsin-Madison. Department of Medical Microbiology and Immunology. Madison, WI, USAUniversitätsklinikum Bonn. Institute of Molecular Medicine. Bonn,GermanyUniversitätsklinikum Bonn. Institute of Molecular Medicine. Bonn,Germany Katherine A. Fitzgerald/University of Massachusetts Medical School. Division of Infectious Diseases. Worcester, MA, USA/University of Massachusetts Medical School. Department of Medicine. Program in Innate Immunity. Worcester, MA, USA/Norwegian University of Science and Technology. Centre of Molecular Inflammation Research and Department of Cancer Research and Molecular Medicine. Trondheim, NorwayUniversity of Massachusetts Medical School. Division of Infectious Diseases. Worcester, MA, USA/University of Massachusetts Medical School. Department of Medicine. Program in Innate Immunity.University of Massachusetts Medical School. Division of Infectious Diseases. Worcester, MA, USA/ University of Massachusetts Medical School. Department of Medicine. Program in Innate Immunity/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilThe innate immune system is the first line of defense against Neisseria gonorrhoeae (GC). Exposure of cells to GC lipooligosaccharides induces a strong immune response, leading to type I interferon (IFN) production via TLR4/MD-2. In addition to living freely in the extracellular space, GC can invade the cytoplasm to evade detection and elimination. Double-stranded DNA introduced into the cytosol binds and activates the enzyme cyclic-GMP-AMP synthase (cGAS), which produces 2′3′-cGAMP and triggers STING/TBK-1/IRF3 activation, resulting in type I IFN expression. Here, we reveal a cytosolic response to GC DNA that also contributes to type I IFN induction. We demonstrate that complete IFN-β induction by live GC depends on both cGAS and TLR4. Type I IFN is detrimental to the host, and dysregulation of iron homeostasis genes may explain lower bacteria survival in cGAS−/− and TLR4−/− cells. Collectively, these observations reveal cooperation between TLRs and cGAS in immunity to GC infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/18431/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALve_Andrade_Warrison_Type I Interferon_CPqRR_2016.pdfve_Andrade_Warrison_Type I Interferon_CPqRR_2016.pdfapplication/pdf4696746https://www.arca.fiocruz.br/bitstream/icict/18431/2/ve_Andrade_Warrison_Type%20I%20Interferon_CPqRR_2016.pdfe38d65ae3a03ce767b88e6c42879aa73MD52TEXTve_Andrade_Warrison_Type I Interferon_CPqRR_2016.pdf.txtve_Andrade_Warrison_Type I Interferon_CPqRR_2016.pdf.txtExtracted texttext/plain10672https://www.arca.fiocruz.br/bitstream/icict/18431/3/ve_Andrade_Warrison_Type%20I%20Interferon_CPqRR_2016.pdf.txt9680994b8dbe1fb18fb9cef4d5849ec9MD53icict/184312019-06-19 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dc.title.pt_BR.fl_str_mv Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4
title Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4
spellingShingle Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4
Andrade, Warrison A.
Neisseria gonorrhoeae
sistema imune inato
type I interferon
cGAS
STING
TLR4
Neisseria gonorrhoeae
title_short Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4
title_full Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4
title_fullStr Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4
title_full_unstemmed Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4
title_sort Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4
author Andrade, Warrison A.
author_facet Andrade, Warrison A.
Agarwal, Sarika
Mo, Shunyan
Shaffer, Scott A.
Dillard, Joseph P.
Schmidt, Tobias
Hornung, Veit
Kurt-Jones, Evelyn A.
Golenbock, Douglas T.
author_role author
author2 Agarwal, Sarika
Mo, Shunyan
Shaffer, Scott A.
Dillard, Joseph P.
Schmidt, Tobias
Hornung, Veit
Kurt-Jones, Evelyn A.
Golenbock, Douglas T.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Warrison A.
Agarwal, Sarika
Mo, Shunyan
Shaffer, Scott A.
Dillard, Joseph P.
Schmidt, Tobias
Hornung, Veit
Kurt-Jones, Evelyn A.
Golenbock, Douglas T.
dc.subject.other.pt_BR.fl_str_mv Neisseria gonorrhoeae
sistema imune inato
topic Neisseria gonorrhoeae
sistema imune inato
type I interferon
cGAS
STING
TLR4
Neisseria gonorrhoeae
dc.subject.en.pt_BR.fl_str_mv type I interferon
cGAS
STING
TLR4
Neisseria gonorrhoeae
description University of Massachusetts Medical School. Division of Infectious Diseases. Worcester, MA, USA/University of Massachusetts Medical School. Department of Medicine. Program in Innate Immunity. Worcester, MA, USA
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-04-12T18:42:07Z
dc.date.available.fl_str_mv 2017-04-12T18:42:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Warrison A et al. Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4. Cell Reports, v. 15, n. 11, p. 2438 – 2448, 2016
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/18431
dc.identifier.issn.pt_BR.fl_str_mv 2211-1247
dc.identifier.doi.none.fl_str_mv 10.1016/j.celrep.2016.05.030.
identifier_str_mv ANDRADE, Warrison A et al. Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4. Cell Reports, v. 15, n. 11, p. 2438 – 2448, 2016
2211-1247
10.1016/j.celrep.2016.05.030.
url https://www.arca.fiocruz.br/handle/icict/18431
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/18431/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/18431/2/ve_Andrade_Warrison_Type%20I%20Interferon_CPqRR_2016.pdf
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