Immunologic Markers of Protection in Leishmania (Viannia) braziliensis Infection: A 5-Year Cohort Study

Detalhes bibliográficos
Autor(a) principal: Muniz, Aline de Couto
Data de Publicação: 2016
Outros Autores: Bacellar, Olívia, Lago, Ednaldo Lima, Carvalho, Augusto M, Carneiro, Pedro Paulo, Guimarães, Luiz Henrique, Rocha, Paulo N, Carvalho, Lucas P, Glesby, Marshall, Carvalho Filho, Edgar Marcelino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16408
Resumo: Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil
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spelling Muniz, Aline de CoutoBacellar, OlíviaLago, Ednaldo LimaCarvalho, Augusto MCarneiro, Pedro PauloGuimarães, Luiz HenriqueRocha, Paulo NCarvalho, Lucas PGlesby, MarshallCarvalho Filho, Edgar Marcelino2016-12-01T16:45:05Z2016-12-01T16:45:05Z2016MUNIZ, A. C. et al. Immunologic Markers of Protection in Leishmania (Viannia) braziliensis Infection: A 5-Year Cohort Study. Journal of Infectious Diseases,v. 214, p. 570–576, 2016.0022-1899https://www.arca.fiocruz.br/handle/icict/1640810.1093/infdis/jiw196engOxford University PressLeishmanioseContatos domésticosLeishmania braziliensisLeishmaniose cutâneaIFN-yLeishmania teste cutâneoSubclinical leishmaniasisHousehold contactsLeishmania braziliensisCutaneous leishmaniasisIFN-γLeishmania skin testImmunologic Markers of Protection in Leishmania (Viannia) braziliensis Infection: A 5-Year Cohort Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, BrasilFederal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilFederal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilFederal University of Bahia School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFederal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, BrasilFederal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilFederal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Federal University of Bahia School of Medicine. Department of Medicine and Diagnostic Support. Salvador, BA, BrasilFederal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilWeill Cornell Medical College. New York, New YorkFederal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilThe control of Leishmania braziliensis by individuals with subclinical infection (SC) are unknown.Methods. A cohort of 308 household contacts (HCs) of patients with cutaneous leishmaniasis (CL) was established in 2010 in an endemic area and followed up for 5 years. Whole-blood cultures stimulated with soluble Leishmania antigen and a Leishmania skin test (LST) were performed in years 0, 2, and 4. The identification of the lymphocyte subsets secreting interferon (IFN) γ and the ability of monocytes to control Leishmania were determined. Results. During follow-up, 118 subjects (38.3%) had evidence of L. braziliensis infection. Of the HCs, CL was documented in 45 (14.6%), 101 (32.8%) had SC infection, and 162 (52.6%) did not have evidence of exposure to L. braziliensis. The ratio of infection to disease was 3.2:1. IFN-γ production, mainly by natural killer cells, was associated with protection, and a positive LST result did not prevent development of disease. Moreover, monocytes from subjects with SC infection were less permissive to parasite penetration and had a greater ability to control L. braziliensis than cells from patients with CL. Conclusions. Protection against CL was associated with IFN-γ production, negative LST results, impaired ability of Leishmania to penetrate monocytes, and increased ability to control Leishmania growthinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16408/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMuniz AC Immunologic markers....pdfMuniz AC Immunologic markers....pdfapplication/pdf355094https://www.arca.fiocruz.br/bitstream/icict/16408/2/Muniz%20AC%20Immunologic%20markers....pdfcca5a573f52625464e788b34e4986621MD52TEXTMuniz AC Immunologic markers....pdf.txtMuniz AC Immunologic markers....pdf.txtExtracted texttext/plain35230https://www.arca.fiocruz.br/bitstream/icict/16408/3/Muniz%20AC%20Immunologic%20markers....pdf.txted7f54f480e9fb3ff70bcf976a47b1dcMD53icict/164082023-03-15 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dc.title.pt_BR.fl_str_mv Immunologic Markers of Protection in Leishmania (Viannia) braziliensis Infection: A 5-Year Cohort Study
title Immunologic Markers of Protection in Leishmania (Viannia) braziliensis Infection: A 5-Year Cohort Study
spellingShingle Immunologic Markers of Protection in Leishmania (Viannia) braziliensis Infection: A 5-Year Cohort Study
Muniz, Aline de Couto
Leishmaniose
Contatos domésticos
Leishmania braziliensis
Leishmaniose cutânea
IFN-y
Leishmania teste cutâneo
Subclinical leishmaniasis
Household contacts
Leishmania braziliensis
Cutaneous leishmaniasis
IFN-γ
Leishmania skin test
title_short Immunologic Markers of Protection in Leishmania (Viannia) braziliensis Infection: A 5-Year Cohort Study
title_full Immunologic Markers of Protection in Leishmania (Viannia) braziliensis Infection: A 5-Year Cohort Study
title_fullStr Immunologic Markers of Protection in Leishmania (Viannia) braziliensis Infection: A 5-Year Cohort Study
title_full_unstemmed Immunologic Markers of Protection in Leishmania (Viannia) braziliensis Infection: A 5-Year Cohort Study
title_sort Immunologic Markers of Protection in Leishmania (Viannia) braziliensis Infection: A 5-Year Cohort Study
author Muniz, Aline de Couto
author_facet Muniz, Aline de Couto
Bacellar, Olívia
Lago, Ednaldo Lima
Carvalho, Augusto M
Carneiro, Pedro Paulo
Guimarães, Luiz Henrique
Rocha, Paulo N
Carvalho, Lucas P
Glesby, Marshall
Carvalho Filho, Edgar Marcelino
author_role author
author2 Bacellar, Olívia
Lago, Ednaldo Lima
Carvalho, Augusto M
Carneiro, Pedro Paulo
Guimarães, Luiz Henrique
Rocha, Paulo N
Carvalho, Lucas P
Glesby, Marshall
Carvalho Filho, Edgar Marcelino
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Muniz, Aline de Couto
Bacellar, Olívia
Lago, Ednaldo Lima
Carvalho, Augusto M
Carneiro, Pedro Paulo
Guimarães, Luiz Henrique
Rocha, Paulo N
Carvalho, Lucas P
Glesby, Marshall
Carvalho Filho, Edgar Marcelino
dc.subject.other.pt_BR.fl_str_mv Leishmaniose
Contatos domésticos
Leishmania braziliensis
Leishmaniose cutânea
IFN-y
Leishmania teste cutâneo
topic Leishmaniose
Contatos domésticos
Leishmania braziliensis
Leishmaniose cutânea
IFN-y
Leishmania teste cutâneo
Subclinical leishmaniasis
Household contacts
Leishmania braziliensis
Cutaneous leishmaniasis
IFN-γ
Leishmania skin test
dc.subject.en.pt_BR.fl_str_mv Subclinical leishmaniasis
Household contacts
Leishmania braziliensis
Cutaneous leishmaniasis
IFN-γ
Leishmania skin test
description Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-12-01T16:45:05Z
dc.date.available.fl_str_mv 2016-12-01T16:45:05Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MUNIZ, A. C. et al. Immunologic Markers of Protection in Leishmania (Viannia) braziliensis Infection: A 5-Year Cohort Study. Journal of Infectious Diseases,v. 214, p. 570–576, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16408
dc.identifier.issn.pt_BR.fl_str_mv 0022-1899
dc.identifier.doi.none.fl_str_mv 10.1093/infdis/jiw196
identifier_str_mv MUNIZ, A. C. et al. Immunologic Markers of Protection in Leishmania (Viannia) braziliensis Infection: A 5-Year Cohort Study. Journal of Infectious Diseases,v. 214, p. 570–576, 2016.
0022-1899
10.1093/infdis/jiw196
url https://www.arca.fiocruz.br/handle/icict/16408
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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