FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation

Junqueira, Caroline; Crespo, Ângela; Ranjbar, Shahin; Lacerda, Luna B. de; Lewandrowski, Mercedes; Ingber, Jacob; Parry, Blair; Ravid, Sagi; Clark, Sarah; Schrimpf, Marie Rose; Ho, Felicia; Beakes, Caroline; Margolin, Justin; Russell, Nicole; Kays, Kyle; Boucau, Julie; Adhikar, Upasana Das; Vora, Setu M.; Leger, Valerie; Gehrke, Lee; Henderson, Lauren; Janssen, Erin; Kwon, Douglas; Sander, Chris; Abraham, Jonathan; Goldberg, Marcia B.; Hao, Wu; Mehta, Gautam; Bell, Steven; Goldfeld, Anne E.; Filbin, Michael R.; Lieberman, Judy

FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation

Detalhes bibliográficos
Autor(a) principal:	Junqueira, Caroline
Data de Publicação:	2022
Outros Autores:	Crespo, Ângela, Ranjbar, Shahin, Lacerda, Luna B. de, Lewandrowski, Mercedes, Ingber, Jacob, Parry, Blair, Ravid, Sagi, Clark, Sarah, Schrimpf, Marie Rose, Ho, Felicia, Beakes, Caroline, Margolin, Justin, Russell, Nicole, Kays, Kyle, Boucau, Julie, Adhikar, Upasana Das, Vora, Setu M., Leger, Valerie, Gehrke, Lee, Henderson, Lauren, Janssen, Erin, Kwon, Douglas, Sander, Chris, Abraham, Jonathan, Goldberg, Marcia B., Hao, Wu, Mehta, Gautam, Bell, Steven, Goldfeld, Anne E., Filbin, Michael R., Lieberman, Judy
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/52090
Resumo:	Boston Children's Hospital. Program in Cellular and Molecular Medicine. Boston, MA, USA / Harvard Medical School. Department of Pediatrics. Boston, MA, USA / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.

Metadados do item

id	CRUZ_470767dc3f9e9f5552ff0721dde8ae20
oai_identifier_str	oai:www.arca.fiocruz.br:icict/52090
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Junqueira, CarolineCrespo, ÂngelaRanjbar, ShahinLacerda, Luna B. deLewandrowski, MercedesIngber, JacobParry, BlairRavid, SagiClark, SarahSchrimpf, Marie RoseHo, FeliciaBeakes, CarolineMargolin, JustinRussell, NicoleKays, KyleBoucau, JulieAdhikar, Upasana DasVora, Setu M.Leger, ValerieGehrke, LeeHenderson, LaurenJanssen, ErinKwon, DouglasSander, ChrisAbraham, JonathanGoldberg, Marcia B.Hao, WuMehta, GautamBell, StevenGoldfeld, Anne E.Filbin, Michael R.Lieberman, Judy2022-04-07T15:33:49Z2022-04-07T15:33:49Z2022JUNQUEIRA, Caroline et al. FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation. Nature, p. 1-27, 6 Apr. 2022.0028-0836https://www.arca.fiocruz.br/handle/icict/5209010.1038/s41586-022-04702-41476-4687engNature ResearchFcγR-mediated SARS-CoV-2 infection of monocytes activates inflammationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBoston Children's Hospital. Program in Cellular and Molecular Medicine. Boston, MA, USA / Harvard Medical School. Department of Pediatrics. Boston, MA, USA / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Boston Children's Hospital. Program in Cellular and Molecular Medicine. Boston, MA, USA / Harvard Medical School. Department of Pediatrics. Boston, MA, USA.Boston Children's Hospital. Program in Cellular and Molecular Medicine. Boston, MA, USA / Harvard Medical School. Department of Pediatrics. Boston, MA, USA.Harvard Medical School. Department of Pediatrics. Boston, MA, USA / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Harvard Medical School. Department of Pediatrics. Boston, MA, USA.Harvard Medical School. Department of Pediatrics. Boston, MA, USA.Massachusetts General Hospital Institute for Patient Care. Emergency Medicine. Boston, MA, USA.Harvard Medical School. Department of Pediatrics. Boston, MA, USA.Harvard Medical School. Blavatnik Institute. Department of Microbiology. Boston, MA, USA.Boston Children's Hospital. Program in Cellular and Molecular Medicine. Boston, MA, USA / Harvard Medical School. Department of Pediatrics. Boston, MA, USA.Boston Children's Hospital. Program in Cellular and Molecular Medicine. Boston, MA, USA / Harvard Medical School. Department of Pediatrics. Boston, MA, USA.Massachusetts General Hospital Institute for Patient Care. Emergency Medicine. Boston, MA, USA.Massachusetts General Hospital Institute for Patient Care. Emergency Medicine. Boston, MA, USA.Massachusetts General Hospital Institute for Patient Care. Emergency Medicine. Boston, MA, USA.Massachusetts General Hospital Institute for Patient Care. Emergency Medicine. Boston, MA, USA.Harvard Medical School. Massachusetts Institute of Technology. Massachusetts General Hospital. Ragon Institute. Cambridge, MA, USA.Harvard Medical School. Massachusetts Institute of Technology. Massachusetts General Hospital. Ragon Institute. Cambridge, MA, USA.Boston Children's Hospital. Program in Cellular and Molecular Medicine. Boston, MA, USA / Harvard Medical School. Department of Biological Chemistry and Molecular Pharmacology. Boston, MA, USA.Massachusetts Institute of Technology. Institute for Medical Engineering and Science. Cambridge, MA, USA.Harvard Medical School. Blavatnik Institute. Department of Microbiology. Boston, MA, USA / Massachusetts Institute of Technology. Institute for Medical Engineering and Science. Cambridge, MA, USA.Harvard Medical School. Department of Pediatrics. Boston, MA, USA / Boston Children's Hospital. Division of Immunology. Boston, MA, USA.Harvard Medical School. Department of Pediatrics. Boston, MA, USA / Boston Children's Hospital. Division of Immunology. Boston, MA, USA.Harvard Medical School. Massachusetts Institute of Technology. Massachusetts General Hospital. Ragon Institute. Cambridge, MA, USA.Harvard Medical School. Dana-Farber Cancer Institute and Department of Cell Biology. cBio Center. Boston, MA, USA.Harvard Medical School. Blavatnik Institute. Department of Microbiology. Boston, MA, USA.Harvard Medical School. Blavatnik Institute. Department of Microbiology. Boston, MA, USA / Massachusetts General Hospital. Division of Infectious Diseases. Department of Medicine. Center for Bacterial Pathogenesis. Boston, MA, USA.Boston Children's Hospital. Program in Cellular and Molecular Medicine. Boston, MA, USA / Harvard Medical School. Department of Pediatrics. Boston, MA, USA / Massachusetts Institute of Technology. Institute for Medical Engineering and Science. Cambridge, MA, USA.University College London. Institute for Liver and Digestive Health. London, UK / Foundation for Liver Research. Institute of Hepatology. London, UK.University of Cambridge. Department of Clinical Neurosciences. Cambridge, UK.Boston Children's Hospital. Program in Cellular and Molecular Medicine. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA.Massachusetts General Hospital Institute for Patient Care. Emergency Medicine. Boston, MA, USA.Boston Children's Hospital. Program in Cellular and Molecular Medicine. Boston, MA, USA / Harvard Medical School. Department of Pediatrics. Boston, MA, USA.SARS-CoV-2 can cause acute respiratory distress and death in some patients1. Although severe COVID-19 disease is linked to exuberant inflammation, how SARS-CoV-2 triggers inflammation is not understood2. Monocytes and macrophages are sentinel cells that sense invasive infection to form inflammasomes that activate caspase-1 and gasdermin D (GSDMD), leading to inflammatory death (pyroptosis) and release of potent inflammatory mediators3. Here we show that about 6% of blood monocytes in COVID-19 patients are infected with SARS-CoV-2. Monocyte infection depends on uptake of antibody-opsonized virus by Fcγ receptors. Vaccine recipient plasma does not promote antibody-dependent monocyte infection. SARS-CoV-2 begins to replicate in monocytes, but infection is aborted, and infectious virus is not detected in infected monocyte culture supernatants. Instead, infected cells undergo inflammatory cell death (pyroptosis) mediated by activation of NLRP3 and AIM2 inflammasomes, caspase-1 and GSDMD. Moreover, tissue-resident macrophages, but not infected epithelial and endothelial cells, from COVID-19 lung autopsies have activated inflammasomes. These findings taken together suggest that antibody-mediated SARS-CoV-2 uptake by monocytes/macrophages triggers inflammatory cell death that aborts production of infectious virus but causes systemic inflammation that contributes to COVID-19 pathogenesis.Antimicrobial responsesImmune cell deathMonocytes and macrophagesSARS-CoV-2info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83132https://www.arca.fiocruz.br/bitstream/icict/52090/1/license.txt33967fcc8ef681b8f5c2c34178ebc114MD51ORIGINALve_Caroline_Junqueira_etal_IRR_2022.pdfve_Caroline_Junqueira_etal_IRR_2022.pdfapplication/pdf11423656https://www.arca.fiocruz.br/bitstream/icict/52090/2/ve_Caroline_Junqueira_etal_IRR_2022.pdfa7e3f98e410d8781c902a0d21f483efaMD52icict/520902022-04-10 20:39:15.963oai:www.arca.fiocruz.br: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ório 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dc.title.pt_BR.fl_str_mv	FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
title	FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
spellingShingle	FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation Junqueira, Caroline Antimicrobial responses Immune cell death Monocytes and macrophages SARS-CoV-2
title_short	FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
title_full	FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
title_fullStr	FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
title_full_unstemmed	FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
title_sort	FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
author	Junqueira, Caroline
author_facet	Junqueira, Caroline Crespo, Ângela Ranjbar, Shahin Lacerda, Luna B. de Lewandrowski, Mercedes Ingber, Jacob Parry, Blair Ravid, Sagi Clark, Sarah Schrimpf, Marie Rose Ho, Felicia Beakes, Caroline Margolin, Justin Russell, Nicole Kays, Kyle Boucau, Julie Adhikar, Upasana Das Vora, Setu M. Leger, Valerie Gehrke, Lee Henderson, Lauren Janssen, Erin Kwon, Douglas Sander, Chris Abraham, Jonathan Goldberg, Marcia B. Hao, Wu Mehta, Gautam Bell, Steven Goldfeld, Anne E. Filbin, Michael R. Lieberman, Judy
author_role	author
author2	Crespo, Ângela Ranjbar, Shahin Lacerda, Luna B. de Lewandrowski, Mercedes Ingber, Jacob Parry, Blair Ravid, Sagi Clark, Sarah Schrimpf, Marie Rose Ho, Felicia Beakes, Caroline Margolin, Justin Russell, Nicole Kays, Kyle Boucau, Julie Adhikar, Upasana Das Vora, Setu M. Leger, Valerie Gehrke, Lee Henderson, Lauren Janssen, Erin Kwon, Douglas Sander, Chris Abraham, Jonathan Goldberg, Marcia B. Hao, Wu Mehta, Gautam Bell, Steven Goldfeld, Anne E. Filbin, Michael R. Lieberman, Judy
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Junqueira, Caroline Crespo, Ângela Ranjbar, Shahin Lacerda, Luna B. de Lewandrowski, Mercedes Ingber, Jacob Parry, Blair Ravid, Sagi Clark, Sarah Schrimpf, Marie Rose Ho, Felicia Beakes, Caroline Margolin, Justin Russell, Nicole Kays, Kyle Boucau, Julie Adhikar, Upasana Das Vora, Setu M. Leger, Valerie Gehrke, Lee Henderson, Lauren Janssen, Erin Kwon, Douglas Sander, Chris Abraham, Jonathan Goldberg, Marcia B. Hao, Wu Mehta, Gautam Bell, Steven Goldfeld, Anne E. Filbin, Michael R. Lieberman, Judy
dc.subject.en.pt_BR.fl_str_mv	Antimicrobial responses Immune cell death Monocytes and macrophages SARS-CoV-2
topic	Antimicrobial responses Immune cell death Monocytes and macrophages SARS-CoV-2
description	Boston Children's Hospital. Program in Cellular and Molecular Medicine. Boston, MA, USA / Harvard Medical School. Department of Pediatrics. Boston, MA, USA / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.
publishDate	2022
dc.date.accessioned.fl_str_mv	2022-04-07T15:33:49Z
dc.date.available.fl_str_mv	2022-04-07T15:33:49Z
dc.date.issued.fl_str_mv	2022
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	JUNQUEIRA, Caroline et al. FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation. Nature, p. 1-27, 6 Apr. 2022.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/52090
dc.identifier.issn.pt_BR.fl_str_mv	0028-0836
dc.identifier.doi.none.fl_str_mv	10.1038/s41586-022-04702-4
dc.identifier.eissn.none.fl_str_mv	1476-4687
identifier_str_mv	JUNQUEIRA, Caroline et al. FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation. Nature, p. 1-27, 6 Apr. 2022. 0028-0836 10.1038/s41586-022-04702-4 1476-4687
url	https://www.arca.fiocruz.br/handle/icict/52090
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Nature Research
publisher.none.fl_str_mv	Nature Research
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/52090/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/52090/2/ve_Caroline_Junqueira_etal_IRR_2022.pdf
bitstream.checksum.fl_str_mv	33967fcc8ef681b8f5c2c34178ebc114 a7e3f98e410d8781c902a0d21f483efa
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation

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