Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42737 |
Resumo: | Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil |
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Prata-Barbosa, ArnaldoLima-Setta, FernandaSantos, Gustavo Rodrigues dosLanziotti, Vanessa SoaresCastro, Roberta Esteves Vieira deSouza, Daniela Carla deRaymundo, Carlos EduardoOliveira, Felipe Rezende Caino deLima, Lucio Flavio Peixoto deTonial, Cristian TedescoColleti, JoséBellinat, Ana Paula NovaesLorenzo, Vivian BotelhoZeitel, Raquel de SeixasPulcheri, LucasCosta, Fernanda Ciuffo Monte daLa Torre, Fabíola Peixoto FerreiraFigueiredo, Elaine Augusta das NevesSilva, Thiago Peres daRiveiro, Paula MarinsMota, Isabele Coelho Fonseca daBrandão, Igor BromonschenkelAzevedo, Zina Maria Almeida deGregory, Simone CameraBoedo, Fernanda Raquel OliveiraCarvalho, Rosana Novais deCastro, Natália Almeida de Arnaldo Silva RodriguezGenu, Daniel Hilário SantosForonda, Flavia Andrea KrepelCunha, Antonio José Ledo A.Magalhães-Barbosa, Maria Clara de2020-08-12T20:13:10Z2020-08-12T20:13:10Z2020PRATA-BARBOSA, Arnaldo et al. Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study. Jornal de Pediatria, p. 1-11, 2020.0021-7557https://www.arca.fiocruz.br/handle/icict/4273710.1016/j.jped.2020.07.002engSociedade Brasileira de Pediatria (SBP)Elsevierhttps://www.arca.fiocruz.br/handle/icict/44322Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, BrasilInstituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, BrasilInstituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Hospital Sírio Libanês. São Paulo, SP, Brasil.Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, BrasilHospital Alvorada Moema, São Paulo, SP, Brasil.Hospital SEPACO. São Paulo, SP, Brasil.Pontifícia Universidade Católica. Porto Alegre, RS, Brasil.Hospital Assunção. São Bernardo do Campo, SP, Brasil.Hospital Martagão Gesteira. Salvador, BA, Brasil.Hospital Couto Maia. Salvador, BA, Brasil.Universidade do Estado do Rio de Janeiro. Hospital Pedro Ernesto. Rio de Janeiro, RJ, Brasil.Hospital Rios D’Or. Rio de Janeiro, RJ, Brasil.Hospital Quinta D’Or. Rio de Janeiro, RJ, Brasil.Hospital Sino Brasileiro. Osasco, SP, Brasil.Hospital Pediátrico Unimed. Belém, PA, Brasil.Hospital Real D’Or. Rio de Janeiro, RJ, Brasil.Hospital Caxias D’Or. Duque de Caxias, RJ, Brasil.Hospital Jutta Batista. Rio de Janeiro, RJ, BrasilHospital Niteroi D’Or. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional da Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Hospital Estadual da Criança. Rio de Janeiro, RJ, Brasil.Hospital Norte D’Or. Rio de Janeiro, RJ, Brasil.Santa Casa da Misericórdia. Hospital Santa Izabel. Salvador, BA, Brasil.Faculdade de Medicina. Hospital da Criança. São José do Rio Preto, SP, Brasil.Hospital Estadual Getúlio Vargas. Rio de Janeiro, RJ, Brasil.Hospital Sirio-Libanes. Sao Paulo, SP, Brasil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, BrasilBrazilian Research Network in Pediatric Intensive Care. São Paulo, SP, Brasil.Objective: To describe the clinical characteristics of children and adolescents admitted to intensive care with confirmed COVID-19. Method: Prospective, multicenter, observational study, in 19 pediatric intensive care units. Patients aged 1 month to 19 years admitted consecutively (March–May 2020) were included. Demographic, clinical-epidemiological features, treatment, and outcomes were collected. Subgroups were compared according to comorbidities, age < 1 year, and need for invasive mechanical ventilation. A multivariable logistic regression model was used for predictors of severity. Results: Seventy-nine patients were included (ten with multisystemic inflammatory syndrome). Median age 4 years; 54% male (multisystemic inflammatory syndrome, 80%); 41% had comorbidities (multisystemic inflammatory syndrome, 20%). Fever (76%), cough (51%), and tachypnea (50%) were common in both groups. Severe symptoms, gastrointestinal symptoms, and higher inflammatory markers were more frequent in multisystemic inflammatory syndrome. Interstitial lung infiltrates were common in both groups, but pleural effusion was more prevalent in the multisystemic inflammatory syndrome group (43% vs. 14%). Invasive mechanical ventilation was used in 18% (median 7.5 days); antibiotics, oseltamivir, and corticosteroids were used in 76%, 43%, and 23%, respectively, but not hydroxychloroquine. The median pediatric intensive care unit length-of-stay was five days; there were two deaths (3%) in the non- multisystemic inflammatory syndrome group. Patients with comorbidities were older, and comorbidities were independently associated with the need for invasive mechanical ventilation (OR 5.5; 95% CI, 1.43–21.12; p = 0.01). Conclusions: In Brazilian pediatric intensive care units, COVID-19 had low mortality, age less than 1 year was not associated with a worse prognosis, and patients with multisystemic inflammatory syndrome had more severe symptoms, higher inflammatory biomarkers, and a greater predominance of males, but only comorbidities and chronic diseases were independent predictors of severity.COVID-19SARS-CoV-2Pediatric intensive carePediatricsBrazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study |
| title |
Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study |
| spellingShingle |
Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study Prata-Barbosa, Arnaldo COVID-19 SARS-CoV-2 Pediatric intensive care Pediatrics Brazil |
| title_short |
Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study |
| title_full |
Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study |
| title_fullStr |
Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study |
| title_full_unstemmed |
Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study |
| title_sort |
Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study |
| author |
Prata-Barbosa, Arnaldo |
| author_facet |
Prata-Barbosa, Arnaldo Lima-Setta, Fernanda Santos, Gustavo Rodrigues dos Lanziotti, Vanessa Soares Castro, Roberta Esteves Vieira de Souza, Daniela Carla de Raymundo, Carlos Eduardo Oliveira, Felipe Rezende Caino de Lima, Lucio Flavio Peixoto de Tonial, Cristian Tedesco Colleti, José Bellinat, Ana Paula Novaes Lorenzo, Vivian Botelho Zeitel, Raquel de Seixas Pulcheri, Lucas Costa, Fernanda Ciuffo Monte da La Torre, Fabíola Peixoto Ferreira Figueiredo, Elaine Augusta das Neves Silva, Thiago Peres da Riveiro, Paula Marins Mota, Isabele Coelho Fonseca da Brandão, Igor Bromonschenkel Azevedo, Zina Maria Almeida de Gregory, Simone Camera Boedo, Fernanda Raquel Oliveira Carvalho, Rosana Novais de Castro, Natália Almeida de Arnaldo Silva Rodriguez Genu, Daniel Hilário Santos Foronda, Flavia Andrea Krepel Cunha, Antonio José Ledo A. Magalhães-Barbosa, Maria Clara de |
| author_role |
author |
| author2 |
Lima-Setta, Fernanda Santos, Gustavo Rodrigues dos Lanziotti, Vanessa Soares Castro, Roberta Esteves Vieira de Souza, Daniela Carla de Raymundo, Carlos Eduardo Oliveira, Felipe Rezende Caino de Lima, Lucio Flavio Peixoto de Tonial, Cristian Tedesco Colleti, José Bellinat, Ana Paula Novaes Lorenzo, Vivian Botelho Zeitel, Raquel de Seixas Pulcheri, Lucas Costa, Fernanda Ciuffo Monte da La Torre, Fabíola Peixoto Ferreira Figueiredo, Elaine Augusta das Neves Silva, Thiago Peres da Riveiro, Paula Marins Mota, Isabele Coelho Fonseca da Brandão, Igor Bromonschenkel Azevedo, Zina Maria Almeida de Gregory, Simone Camera Boedo, Fernanda Raquel Oliveira Carvalho, Rosana Novais de Castro, Natália Almeida de Arnaldo Silva Rodriguez Genu, Daniel Hilário Santos Foronda, Flavia Andrea Krepel Cunha, Antonio José Ledo A. Magalhães-Barbosa, Maria Clara de |
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author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
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Prata-Barbosa, Arnaldo Lima-Setta, Fernanda Santos, Gustavo Rodrigues dos Lanziotti, Vanessa Soares Castro, Roberta Esteves Vieira de Souza, Daniela Carla de Raymundo, Carlos Eduardo Oliveira, Felipe Rezende Caino de Lima, Lucio Flavio Peixoto de Tonial, Cristian Tedesco Colleti, José Bellinat, Ana Paula Novaes Lorenzo, Vivian Botelho Zeitel, Raquel de Seixas Pulcheri, Lucas Costa, Fernanda Ciuffo Monte da La Torre, Fabíola Peixoto Ferreira Figueiredo, Elaine Augusta das Neves Silva, Thiago Peres da Riveiro, Paula Marins Mota, Isabele Coelho Fonseca da Brandão, Igor Bromonschenkel Azevedo, Zina Maria Almeida de Gregory, Simone Camera Boedo, Fernanda Raquel Oliveira Carvalho, Rosana Novais de Castro, Natália Almeida de Arnaldo Silva Rodriguez Genu, Daniel Hilário Santos Foronda, Flavia Andrea Krepel Cunha, Antonio José Ledo A. Magalhães-Barbosa, Maria Clara de |
| dc.subject.en.pt_BR.fl_str_mv |
COVID-19 SARS-CoV-2 Pediatric intensive care Pediatrics Brazil |
| topic |
COVID-19 SARS-CoV-2 Pediatric intensive care Pediatrics Brazil |
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Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil |
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2020 |
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2020-08-12T20:13:10Z |
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2020-08-12T20:13:10Z |
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2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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PRATA-BARBOSA, Arnaldo et al. Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study. Jornal de Pediatria, p. 1-11, 2020. |
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https://www.arca.fiocruz.br/handle/icict/42737 |
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0021-7557 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.jped.2020.07.002 |
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PRATA-BARBOSA, Arnaldo et al. Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study. Jornal de Pediatria, p. 1-11, 2020. 0021-7557 10.1016/j.jped.2020.07.002 |
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https://www.arca.fiocruz.br/handle/icict/42737 |
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eng |
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eng |
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https://www.arca.fiocruz.br/handle/icict/44322 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Sociedade Brasileira de Pediatria (SBP) Elsevier |
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Sociedade Brasileira de Pediatria (SBP) Elsevier |
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