Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study

Detalhes bibliográficos
Autor(a) principal: Ticona, Juan P. Aguilar
Data de Publicação: 2021
Outros Autores: Nery Junior, Nivison, Ladines-Lim, Joseph B., Gambrah, Claudia, Sacramento, Gielson, Freitas, Bruno de Paula, Bouzon, Joseane, Oliveira Filho, Jamary, Borja, Ana, Adhikarla, Haritha, Montoya, Magelda, Chin, Athena, WunderJunior, Elsio A., Ballalai, Verena, Vieira, Carina, Belfort, Rubens, AlmeidaI, Antonio R. P., Reis, Mitermayer Galvão dos, HarrisID, Eva, Ko, Albert Icksang, Costa, Federico
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50277
Resumo: 1 Instituto de Sau´de Coletiva, Universidade Federal da Bahia, Salvador, Brazil, 2 Instituto Gonc¸alo Moniz, Fundac¸ão Oswaldo Cruz,Ministe´ rio da Sau´de, Salvador, Brazil, 3 Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America, 4 Hospital Geral Roberto Santos (HGRS), Salvador, Brazil, 5 Faculdade de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil, 6 Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, Brazil, 7 Programa de Pòs-Graduac¸ão em Ciencias da Saude (PPgCS) Universidade Federal da Bahia, Salvador, Brazil, 8 Departamento de Fonoaudiologia. Instituto de Ciências da Sau´de. Universidade Federal da Bahia, Salvador, Brazil, 9 Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, United States of America
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spelling Ticona, Juan P. AguilarNery Junior, NivisonLadines-Lim, Joseph B.Gambrah, ClaudiaSacramento, GielsonFreitas, Bruno de PaulaBouzon, JoseaneOliveira Filho, JamaryBorja, AnaAdhikarla, HarithaMontoya, MageldaChin, AthenaWunderJunior, Elsio A.Ballalai, VerenaVieira, CarinaBelfort, RubensAlmeidaI, Antonio R. P.Reis, Mitermayer Galvão dosHarrisID, EvaKo, Albert IcksangCosta, Federico2021-12-10T11:26:17Z2021-12-10T11:26:17Z2021TICONA, Juan P. Aguilar et al. Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study. PLoS Neglected Tropical Diseases, 2021.1935-2735https://www.arca.fiocruz.br/handle/icict/5027710.1371/journal. pntd.00091621 Instituto de Sau´de Coletiva, Universidade Federal da Bahia, Salvador, Brazil, 2 Instituto Gonc¸alo Moniz, Fundac¸ão Oswaldo Cruz,Ministe´ rio da Sau´de, Salvador, Brazil, 3 Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America, 4 Hospital Geral Roberto Santos (HGRS), Salvador, Brazil, 5 Faculdade de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil, 6 Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, Brazil, 7 Programa de Pòs-Graduac¸ão em Ciencias da Saude (PPgCS) Universidade Federal da Bahia, Salvador, Brazil, 8 Departamento de Fonoaudiologia. Instituto de Ciências da Sau´de. Universidade Federal da Bahia, Salvador, Brazil, 9 Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, United States of AmericaNational Institutes of Health (NIAID R01 AI052473 (AK), R25 U01AI088752 (AK), FIC R01 TW009504 (AK), R25 TW009338 (AK), F31 AI114245 (AK), R01 AI121207 (AK), D43 TW010540 (AK), P01 AI106695 (EH) (https://www. niaid.nih.gov/), Wellcome Trust (102330/Z/13/Z https://wellcome.ac.uk/), Bahia State Research Support Foundation (FAPESB) ZIKA-FAPESB T.O. n ˚ PET0021/2016 (www.fapesb.ba.gov.br) and Coordination for the Improvement of Higher Education (CAPES) from Brazil (https://www.capes. gov.br/)."Múltipla ver em Notas"The prevalence of developmental alterations associated with in-utero Zika virus (ZIKV) exposure in children is not well understood. Furthermore, estimation of the Population Attributable Fraction (PAF) of developmental alterations attributed to ZIKV has not been performed due to lack of population-based cohorts with data on symptomatic and asymptomatic ZIKV exposures and an appropriate control group. The aim of this study was to characterize neurodevelopmental outcomes of children at 11 to 32 months of age with intrauterine ZIKV exposure and estimate the PAF of alterations secondary to ZIKV exposure. Methodology/Principal findings We performed a cohort of biannual community-based prospective serosurveys in a slum community in Salvador, Brazil. We recruited women participating in our cohort, with a documented pregnancy from January 2015 to December 2016 and children born to those mothers. Children were classified as ZIKV exposed in utero (born from women with ZIKV seroconversion during pregnancy) or unexposed (born from women without ZIKV seroconversion or that seroconverted before/after pregnancy) by using an IgG monoclonal antibody blockade-of-binding (BoB). We interviewed mothers and performed anthropometric, audiometric, ophthalmological, neurologic, and neurodevelopmental evaluations of their children at 11 to 32 months of age. Among the 655 women participating in the cohort, 66 (10%) were pregnant during the study period. 46 (70%) of them completed follow-up, of whom ZIKV seroconversion occurred before, during, and after pregnancy in 25 (54%), 13 (28%), and 1 (2%), respectively. The rest of women, 7 (21.2%), did not present ZIKV seroconversion. At 11 to 32 months of life, the 13 ZIKV-exposed children had increased risk of mild cognitive delay (RR 5.1; 95%CI 1.1–24.4) compared with the 33 children unexposed, with a PAF of 53.5%. Exposed children also had increased risk of altered auditory behavior (RR 6.0; 95% CI 1.3–26.9), with a PAF of 59.5%. Conclusions A significant proportion of children exposed in utero to ZIKV developed mild cognitive delay and auditory behavioral abnormalities even in the absence of gross birth defects such as microcephaly and other neurodevelopmental domains. Furthermore, our findings suggest that over half of these abnormalities could be attributed to intrauterine ZIKV exposure.engPublic Library of ScienceZika virusMicrocefaliaAnticorpos MonoclonaisAnormalidades CongênitasZika virusMicrocephalyAntibodies, MonoclonalCongenital AbnormalitiesDevelopmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/50277/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALTicona Juan P. Aguilar Developmental....pdfTicona Juan P. Aguilar Developmental....pdfapplication/pdf1551197https://www.arca.fiocruz.br/bitstream/icict/50277/2/Ticona%20Juan%20P.%20Aguilar%20Developmental....pdf6957627f05e09c869a18b5bfd691d394MD52icict/502772023-03-15 14:34:32.455oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:32Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study
title Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study
spellingShingle Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study
Ticona, Juan P. Aguilar
Zika virus
Microcefalia
Anticorpos Monoclonais
Anormalidades Congênitas
Zika virus
Microcephaly
Antibodies, Monoclonal
Congenital Abnormalities
title_short Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study
title_full Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study
title_fullStr Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study
title_full_unstemmed Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study
title_sort Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study
author Ticona, Juan P. Aguilar
author_facet Ticona, Juan P. Aguilar
Nery Junior, Nivison
Ladines-Lim, Joseph B.
Gambrah, Claudia
Sacramento, Gielson
Freitas, Bruno de Paula
Bouzon, Joseane
Oliveira Filho, Jamary
Borja, Ana
Adhikarla, Haritha
Montoya, Magelda
Chin, Athena
WunderJunior, Elsio A.
Ballalai, Verena
Vieira, Carina
Belfort, Rubens
AlmeidaI, Antonio R. P.
Reis, Mitermayer Galvão dos
HarrisID, Eva
Ko, Albert Icksang
Costa, Federico
author_role author
author2 Nery Junior, Nivison
Ladines-Lim, Joseph B.
Gambrah, Claudia
Sacramento, Gielson
Freitas, Bruno de Paula
Bouzon, Joseane
Oliveira Filho, Jamary
Borja, Ana
Adhikarla, Haritha
Montoya, Magelda
Chin, Athena
WunderJunior, Elsio A.
Ballalai, Verena
Vieira, Carina
Belfort, Rubens
AlmeidaI, Antonio R. P.
Reis, Mitermayer Galvão dos
HarrisID, Eva
Ko, Albert Icksang
Costa, Federico
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ticona, Juan P. Aguilar
Nery Junior, Nivison
Ladines-Lim, Joseph B.
Gambrah, Claudia
Sacramento, Gielson
Freitas, Bruno de Paula
Bouzon, Joseane
Oliveira Filho, Jamary
Borja, Ana
Adhikarla, Haritha
Montoya, Magelda
Chin, Athena
WunderJunior, Elsio A.
Ballalai, Verena
Vieira, Carina
Belfort, Rubens
AlmeidaI, Antonio R. P.
Reis, Mitermayer Galvão dos
HarrisID, Eva
Ko, Albert Icksang
Costa, Federico
dc.subject.other.pt_BR.fl_str_mv Zika virus
Microcefalia
Anticorpos Monoclonais
Anormalidades Congênitas
topic Zika virus
Microcefalia
Anticorpos Monoclonais
Anormalidades Congênitas
Zika virus
Microcephaly
Antibodies, Monoclonal
Congenital Abnormalities
dc.subject.en.pt_BR.fl_str_mv Zika virus
Microcephaly
Antibodies, Monoclonal
Congenital Abnormalities
description 1 Instituto de Sau´de Coletiva, Universidade Federal da Bahia, Salvador, Brazil, 2 Instituto Gonc¸alo Moniz, Fundac¸ão Oswaldo Cruz,Ministe´ rio da Sau´de, Salvador, Brazil, 3 Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America, 4 Hospital Geral Roberto Santos (HGRS), Salvador, Brazil, 5 Faculdade de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil, 6 Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, Brazil, 7 Programa de Pòs-Graduac¸ão em Ciencias da Saude (PPgCS) Universidade Federal da Bahia, Salvador, Brazil, 8 Departamento de Fonoaudiologia. Instituto de Ciências da Sau´de. Universidade Federal da Bahia, Salvador, Brazil, 9 Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, United States of America
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-10T11:26:17Z
dc.date.available.fl_str_mv 2021-12-10T11:26:17Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv TICONA, Juan P. Aguilar et al. Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study. PLoS Neglected Tropical Diseases, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50277
dc.identifier.issn.pt_BR.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal. pntd.0009162
identifier_str_mv TICONA, Juan P. Aguilar et al. Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study. PLoS Neglected Tropical Diseases, 2021.
1935-2735
10.1371/journal. pntd.0009162
url https://www.arca.fiocruz.br/handle/icict/50277
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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