Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10900 |
Resumo: | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil |
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Santos, Jean Nunes dosOliveira, Gabriel Queiroz VasconcelosGurgel, Clarissa Araújo SilvaSouza, Renata Oliveira deSales, Caroline Brandi SchlaepferValença Neto, Alberto de Aguiar PiresRamos, Eduardo Antônio Gonçalves2015-06-17T16:45:18Z2015-06-17T16:45:18Z2009SANTOS, J. N. et al. Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors. Journal of Molecular Histology, v. 40, n. 4, p. 269-275, 2009.1567-2379https://www.arca.fiocruz.br/handle/icict/1090010.1007/s10735-009-9238-xengSpringer VerlagAltered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Laser Center. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilKeratocystic odontogenic tumor (KOT) is a benign cystic tumor that affects the jaw bones and may be associated with the nevoid basal cell carcinoma syndrome (NBCCS). Twenty-five cases diagnosed as KOT, including primary and recurrent tumors and those associated with NBCCS, were submitted to immunohistochemical study for analysis of cytokeratins (CKs) 7, 8, 10, 13, 14, 18 and 19. The results showed CK13 immunostained on the intermediate layers and upper cells. CK14 was expressed in all epithelial layers and in those areas where inflammation and subepithelial splits were present; this protein was preserved within the basal cells. CK 18 was expressed mainly in the basal layer, whereas CK19 was expressed mainly on the intermediate and superficial layers. The remaining CKs tested were not immuoreactive. The status of maturation of cytokeratin seems to be altered on KOTs, and this is not distinct when different tumors are compared.CytokeratinOdontogenic KeratocystsOdontogenic NeoplasmsImmunohistochemistrySíndrome do Nevo Basocelular/patologiaNeoplasias Maxilomandibulares/patologiaQueratinas/biossínteseRecidiva Local de Neoplasia/patologiaCistos Odontogênicos/patologiaAdultoBrasilFemininoHumanosImuno-HistoquímicaQueratinas/químicaMasculinoMeis-Idadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/10900/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALSantos JN Altered expression....pdfSantos JN Altered expression....pdfapplication/pdf332259https://www.arca.fiocruz.br/bitstream/icict/10900/2/Santos%20JN%20Altered%20expression....pdfcabe5a7981bb691f423b52719e8a2f82MD52TEXTSantos JN Altered expression....pdf.txtSantos JN Altered expression....pdf.txtExtracted texttext/plain27697https://www.arca.fiocruz.br/bitstream/icict/10900/3/Santos%20JN%20Altered%20expression....pdf.txtdcbef84693540c85c07480e6bb97b2e5MD53icict/109002023-03-15 14:33:10.674oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:10Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors. |
| title |
Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors. |
| spellingShingle |
Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors. Santos, Jean Nunes dos Cytokeratin Odontogenic Keratocysts Odontogenic Neoplasms Immunohistochemistry Síndrome do Nevo Basocelular/patologia Neoplasias Maxilomandibulares/patologia Queratinas/biossíntese Recidiva Local de Neoplasia/patologia Cistos Odontogênicos/patologia Adulto Brasil Feminino Humanos Imuno-Histoquímica Queratinas/química Masculino Meis-Idade |
| title_short |
Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors. |
| title_full |
Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors. |
| title_fullStr |
Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors. |
| title_full_unstemmed |
Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors. |
| title_sort |
Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors. |
| author |
Santos, Jean Nunes dos |
| author_facet |
Santos, Jean Nunes dos Oliveira, Gabriel Queiroz Vasconcelos Gurgel, Clarissa Araújo Silva Souza, Renata Oliveira de Sales, Caroline Brandi Schlaepfer Valença Neto, Alberto de Aguiar Pires Ramos, Eduardo Antônio Gonçalves |
| author_role |
author |
| author2 |
Oliveira, Gabriel Queiroz Vasconcelos Gurgel, Clarissa Araújo Silva Souza, Renata Oliveira de Sales, Caroline Brandi Schlaepfer Valença Neto, Alberto de Aguiar Pires Ramos, Eduardo Antônio Gonçalves |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Santos, Jean Nunes dos Oliveira, Gabriel Queiroz Vasconcelos Gurgel, Clarissa Araújo Silva Souza, Renata Oliveira de Sales, Caroline Brandi Schlaepfer Valença Neto, Alberto de Aguiar Pires Ramos, Eduardo Antônio Gonçalves |
| dc.subject.en.pt_BR.fl_str_mv |
Cytokeratin Odontogenic Keratocysts Odontogenic Neoplasms Immunohistochemistry |
| topic |
Cytokeratin Odontogenic Keratocysts Odontogenic Neoplasms Immunohistochemistry Síndrome do Nevo Basocelular/patologia Neoplasias Maxilomandibulares/patologia Queratinas/biossíntese Recidiva Local de Neoplasia/patologia Cistos Odontogênicos/patologia Adulto Brasil Feminino Humanos Imuno-Histoquímica Queratinas/química Masculino Meis-Idade |
| dc.subject.decs.pt_BR.fl_str_mv |
Síndrome do Nevo Basocelular/patologia Neoplasias Maxilomandibulares/patologia Queratinas/biossíntese Recidiva Local de Neoplasia/patologia Cistos Odontogênicos/patologia Adulto Brasil Feminino Humanos Imuno-Histoquímica Queratinas/química Masculino Meis-Idade |
| description |
Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil |
| publishDate |
2009 |
| dc.date.issued.fl_str_mv |
2009 |
| dc.date.accessioned.fl_str_mv |
2015-06-17T16:45:18Z |
| dc.date.available.fl_str_mv |
2015-06-17T16:45:18Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
SANTOS, J. N. et al. Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors. Journal of Molecular Histology, v. 40, n. 4, p. 269-275, 2009. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/10900 |
| dc.identifier.issn.none.fl_str_mv |
1567-2379 |
| dc.identifier.doi.none.fl_str_mv |
10.1007/s10735-009-9238-x |
| identifier_str_mv |
SANTOS, J. N. et al. Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors. Journal of Molecular Histology, v. 40, n. 4, p. 269-275, 2009. 1567-2379 10.1007/s10735-009-9238-x |
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https://www.arca.fiocruz.br/handle/icict/10900 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Springer Verlag |
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Springer Verlag |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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