Immunolocalisation of laminin-1 in keratocystic odontogenic tumors.

Detalhes bibliográficos
Autor(a) principal: Gurgel, Clarissa Araújo Silva
Data de Publicação: 2009
Outros Autores: Ramos, Eduardo Antônio Gonçalves, Melo, Leonardo Araújo, Schlaepf, Caroline Brandi, Souza, Renata Oliveira de, Oliveira, Márcio Campos, Santos, Jean Nunes dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10856
Resumo: Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
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spelling Gurgel, Clarissa Araújo SilvaRamos, Eduardo Antônio GonçalvesMelo, Leonardo AraújoSchlaepf, Caroline BrandiSouza, Renata Oliveira deOliveira, Márcio CamposSantos, Jean Nunes dos2015-06-16T19:22:59Z2015-06-16T19:22:59Z2009GURGEL, C. A. S. et al. Immunolocalisation of laminin-1 in keratocystic odontogenic tumors. Acta Histochemica, v. 112, n. 6, p. 624-629, 2010.0065-1281https://www.arca.fiocruz.br/handle/icict/10856engElsevierImmunolocalisation of laminin-1 in keratocystic odontogenic tumors.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Salvador, BA, BrasilUniversity of Feira de Santana. School of Dentistry. Laboratory of Oral Surgical Pathology. Feira de Santana, BA, BrasilFederal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, BrasilKeratocystic odontogenic tumors (KOTs) are distinct odontogenic lesions frequently affecting the jawbones. They may be associated with nevoid basal cell carcinoma syndrome (NBCCS), and may exhibit disorders involving the extracellular matrix. The aim of this study was to investigate the immunolocalisation of laminin-1 in 20 cases of KOTs in order to contribute to the characterization of this protein, which is little studied in odontogenic tumors. Our results showed laminin-1 in all 20 KOTs studied; its labelling intensity was weak in three cases (15%), moderate in five (25%) and strong in 12 cases (60%). Laminin-1 immunolocalisation was predominantly continuous in 18 (90%) KOTs, including areas of acanthosis, subepithelial split and epithelial buds. Weak immunolabelling was observed in regions exhibiting an inflammatory process, especially in the case of intense inflammation. These findings suggest that laminin-1 does not participate in biological processes such as cystic epithelium-cystic wall separation or the formation of epithelial islands in KOTs. Furthermore, the discontinuous and weak labelling of this protein in the basement membrane of these tumors is probably a consequence of the inflammatory process in the tumor stromaKeratocysticodontogenic tumorsLaminin-1ImmunohistochemistryNeoplasias Maxilomandibulares/metabolismoNeoplasias Maxilomandibulares/patologiaLaminina/análiseTumores Odontogênicos/metabolismoTumores Odontogênicos/patologiaHumanosImuno-HistoquímicaNeoplasias Maxilomandibulares/imunologiaLaminina/imunologiaTumores Odontogênicos/imunologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/10856/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALSilva C A G Immunolocalisation....pdfSilva C A G Immunolocalisation....pdfapplication/pdf614189https://www.arca.fiocruz.br/bitstream/icict/10856/2/Silva%20C%20A%20G%20Immunolocalisation....pdf2b3517ce8f70091e4d76db96b5692a1bMD52TEXTSilva C A G Immunolocalisation....pdf.txtSilva C A G Immunolocalisation....pdf.txtExtracted texttext/plain20084https://www.arca.fiocruz.br/bitstream/icict/10856/3/Silva%20C%20A%20G%20Immunolocalisation....pdf.txt785fc2194387f89906913d7d26314476MD53icict/108562023-03-15 14:33:08.6oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:08Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Immunolocalisation of laminin-1 in keratocystic odontogenic tumors.
title Immunolocalisation of laminin-1 in keratocystic odontogenic tumors.
spellingShingle Immunolocalisation of laminin-1 in keratocystic odontogenic tumors.
Gurgel, Clarissa Araújo Silva
Keratocysticodontogenic tumors
Laminin-1
Immunohistochemistry
Neoplasias Maxilomandibulares/metabolismo
Neoplasias Maxilomandibulares/patologia
Laminina/análise
Tumores Odontogênicos/metabolismo
Tumores Odontogênicos/patologia
Humanos
Imuno-Histoquímica
Neoplasias Maxilomandibulares/imunologia
Laminina/imunologia
Tumores Odontogênicos/imunologia
title_short Immunolocalisation of laminin-1 in keratocystic odontogenic tumors.
title_full Immunolocalisation of laminin-1 in keratocystic odontogenic tumors.
title_fullStr Immunolocalisation of laminin-1 in keratocystic odontogenic tumors.
title_full_unstemmed Immunolocalisation of laminin-1 in keratocystic odontogenic tumors.
title_sort Immunolocalisation of laminin-1 in keratocystic odontogenic tumors.
author Gurgel, Clarissa Araújo Silva
author_facet Gurgel, Clarissa Araújo Silva
Ramos, Eduardo Antônio Gonçalves
Melo, Leonardo Araújo
Schlaepf, Caroline Brandi
Souza, Renata Oliveira de
Oliveira, Márcio Campos
Santos, Jean Nunes dos
author_role author
author2 Ramos, Eduardo Antônio Gonçalves
Melo, Leonardo Araújo
Schlaepf, Caroline Brandi
Souza, Renata Oliveira de
Oliveira, Márcio Campos
Santos, Jean Nunes dos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gurgel, Clarissa Araújo Silva
Ramos, Eduardo Antônio Gonçalves
Melo, Leonardo Araújo
Schlaepf, Caroline Brandi
Souza, Renata Oliveira de
Oliveira, Márcio Campos
Santos, Jean Nunes dos
dc.subject.en.pt_BR.fl_str_mv Keratocysticodontogenic tumors
Laminin-1
Immunohistochemistry
topic Keratocysticodontogenic tumors
Laminin-1
Immunohistochemistry
Neoplasias Maxilomandibulares/metabolismo
Neoplasias Maxilomandibulares/patologia
Laminina/análise
Tumores Odontogênicos/metabolismo
Tumores Odontogênicos/patologia
Humanos
Imuno-Histoquímica
Neoplasias Maxilomandibulares/imunologia
Laminina/imunologia
Tumores Odontogênicos/imunologia
dc.subject.decs.pt_BR.fl_str_mv Neoplasias Maxilomandibulares/metabolismo
Neoplasias Maxilomandibulares/patologia
Laminina/análise
Tumores Odontogênicos/metabolismo
Tumores Odontogênicos/patologia
Humanos
Imuno-Histoquímica
Neoplasias Maxilomandibulares/imunologia
Laminina/imunologia
Tumores Odontogênicos/imunologia
description Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2015-06-16T19:22:59Z
dc.date.available.fl_str_mv 2015-06-16T19:22:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GURGEL, C. A. S. et al. Immunolocalisation of laminin-1 in keratocystic odontogenic tumors. Acta Histochemica, v. 112, n. 6, p. 624-629, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10856
dc.identifier.issn.none.fl_str_mv 0065-1281
identifier_str_mv GURGEL, C. A. S. et al. Immunolocalisation of laminin-1 in keratocystic odontogenic tumors. Acta Histochemica, v. 112, n. 6, p. 624-629, 2010.
0065-1281
url https://www.arca.fiocruz.br/handle/icict/10856
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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