Alkaloidal metabolites from Aspergillus felis and their activities against Paracoccidioides brasiliensis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/17848 http://dx.doi.org/10.1016/j.phytol.2016.06.006 |
Resumo: | 2021-01-01 |
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Mendes, GrazieleOliveira, Djalma de MenezesKohlhoff, MarkusRosa, Carlos AugustoAlves, Tânia Maria de AlmeidaZani, Carlos LeomarRosa, Luiz HenriqueJohann, SusanaCota, Betania Barros2017-02-16T18:33:41Z2017-02-16T18:33:41Z2016MENDES, Graziele et al. Alkaloidal metabolites from Aspergillus felis and their activities against Paracoccidioides brasiliensis. Phytochemistry Letters, v. 17, p 28–35, 20161874-3900https://www.arca.fiocruz.br/handle/icict/17848http://dx.doi.org/10.1016/j.phytol.2016.06.006engElsevier LtdAspergillusAspergillusfelisAlkaloidalmetabolitesPerhydroisoindolParacoccidioidesbrasiliensisAntifungalactivitAlkaloidal metabolites from Aspergillus felis and their activities against Paracoccidioides brasiliensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2021-01-01Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, BrasilUniversidade Estadual Sudoeste da Bahia. Departamento de Quimica. Jequié, BA, BrazilFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Química de Produtos Naturais Bioativos. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Química de Produtos Naturais Bioativos. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Química de Produtos Naturais Bioativos. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Química de Produtos Naturais Bioativos. Belo Horizonte, MG, BrasilIn this study, the fungus Aspergillus felis (strain UFMGCB 8030) was isolated from rocks in the Atacama Desert, Chile. Its CH2Cl2 extract exhibited antifungal activity (MIC of 1.9 μg/mL) against Paracoccidioides brasiliensis (Pb18), which is the etiological agent for paracoccidioidomycosis. The crude extract was purified, and a new cytochalasin derivative, cytochalasin Z15E (1), and one ardeemin derivative, 5-N-acetyl-8-β-isopropyl-ardeemin (4), in addition to five known secondary metabolites, rosellichalasin (2), cytochalasin E (3), gancidin (5), pseurotin A1 (6), and 2,4-dihydroxyacetophenone (7), were isolated. The structures of these compounds were confirmed by 1D and 2D NMR spectroscopy and HR-ESI⿿MS. Cytochalasin E was the most active compound with MIC an value of 3.6 μM, while the other isolated compounds exhibited weak antifungal activities (MIC values >100.0 μM).info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/17848/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALve_Mendes_Graziele_Alkaloidal_CPqRR-2016.pdfve_Mendes_Graziele_Alkaloidal_CPqRR-2016.pdfapplication/pdf759159https://www.arca.fiocruz.br/bitstream/icict/17848/2/ve_Mendes_Graziele_Alkaloidal_CPqRR-2016.pdf39ff277f3af9fac671df418b5959b494MD52TEXTve_Mendes_Graziele_Alkaloidal_CPqRR-2016.pdf.txtve_Mendes_Graziele_Alkaloidal_CPqRR-2016.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Alkaloidal metabolites from Aspergillus felis and their activities against Paracoccidioides brasiliensis |
| title |
Alkaloidal metabolites from Aspergillus felis and their activities against Paracoccidioides brasiliensis |
| spellingShingle |
Alkaloidal metabolites from Aspergillus felis and their activities against Paracoccidioides brasiliensis Mendes, Graziele Aspergillus Aspergillus felis Alkaloidal metabolites Perhydroisoindol Paracoccidioides brasiliensis Antifungal activit |
| title_short |
Alkaloidal metabolites from Aspergillus felis and their activities against Paracoccidioides brasiliensis |
| title_full |
Alkaloidal metabolites from Aspergillus felis and their activities against Paracoccidioides brasiliensis |
| title_fullStr |
Alkaloidal metabolites from Aspergillus felis and their activities against Paracoccidioides brasiliensis |
| title_full_unstemmed |
Alkaloidal metabolites from Aspergillus felis and their activities against Paracoccidioides brasiliensis |
| title_sort |
Alkaloidal metabolites from Aspergillus felis and their activities against Paracoccidioides brasiliensis |
| author |
Mendes, Graziele |
| author_facet |
Mendes, Graziele Oliveira, Djalma de Menezes Kohlhoff, Markus Rosa, Carlos Augusto Alves, Tânia Maria de Almeida Zani, Carlos Leomar Rosa, Luiz Henrique Johann, Susana Cota, Betania Barros |
| author_role |
author |
| author2 |
Oliveira, Djalma de Menezes Kohlhoff, Markus Rosa, Carlos Augusto Alves, Tânia Maria de Almeida Zani, Carlos Leomar Rosa, Luiz Henrique Johann, Susana Cota, Betania Barros |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mendes, Graziele Oliveira, Djalma de Menezes Kohlhoff, Markus Rosa, Carlos Augusto Alves, Tânia Maria de Almeida Zani, Carlos Leomar Rosa, Luiz Henrique Johann, Susana Cota, Betania Barros |
| dc.subject.other.pt_BR.fl_str_mv |
Aspergillus |
| topic |
Aspergillus Aspergillus felis Alkaloidal metabolites Perhydroisoindol Paracoccidioides brasiliensis Antifungal activit |
| dc.subject.en.pt_BR.fl_str_mv |
Aspergillus felis Alkaloidal metabolites Perhydroisoindol Paracoccidioides brasiliensis Antifungal activit |
| description |
2021-01-01 |
| publishDate |
2016 |
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2016 |
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2017-02-16T18:33:41Z |
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2017-02-16T18:33:41Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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MENDES, Graziele et al. Alkaloidal metabolites from Aspergillus felis and their activities against Paracoccidioides brasiliensis. Phytochemistry Letters, v. 17, p 28–35, 2016 |
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https://www.arca.fiocruz.br/handle/icict/17848 |
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1874-3900 |
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http://dx.doi.org/10.1016/j.phytol.2016.06.006 |
| identifier_str_mv |
MENDES, Graziele et al. Alkaloidal metabolites from Aspergillus felis and their activities against Paracoccidioides brasiliensis. Phytochemistry Letters, v. 17, p 28–35, 2016 1874-3900 |
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https://www.arca.fiocruz.br/handle/icict/17848 http://dx.doi.org/10.1016/j.phytol.2016.06.006 |
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Elsevier Ltd |
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Elsevier Ltd |
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