De novo design and biophysical characterization of an Affinity-Enhanced Protein displaying the structure of the broadly neutralizing HIV-1 2F5 Antibody Epitope

Detalhes bibliográficos
Autor(a) principal: Viana, Isabelle Freire Tabosa
Data de Publicação: 2016
Outros Autores: Nascimento, Eduardo, Krieger, Marco Aurélio, Craigo, Jodi, Mailliard, Robbie, Rafael, Dhalia, Lins, Roberto, Marques, Ernesto T. A.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20494
Resumo: Center for Vaccine Research and Infectious Diseases and Microbiology Department. University of Pittsburgh. Pittsburgh, PA, USA.
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spelling Viana, Isabelle Freire TabosaNascimento, EduardoKrieger, Marco AurélioCraigo, JodiMailliard, RobbieRafael, DhaliaLins, RobertoMarques, Ernesto T. A.2017-08-02T16:37:35Z2017-08-02T16:37:35Z2016VIANA, Isabelle Freire Tabosa et al. De Novo Design and Biophysical Characterization of an Affinity-Enhanced Protein Displaying the Structure of the Broadly Neutralizing HIV-1 2F5 Antibody Epitope. Biophysical Journal, v. 110 , n. 3, p. 346a, 2016.0006-3495https://www.arca.fiocruz.br/handle/icict/20494org/10.1016/j.bpj.2015.11.1860porBiophysical SocietyImunogenicidade da VacinaHIV-1HIV AntibodiesVaccineVIH-1Anticuerpos Anti-VIHVacunalHIV-1Anticorpos Anti-HIVVacinaDe novo design and biophysical characterization of an Affinity-Enhanced Protein displaying the structure of the broadly neutralizing HIV-1 2F5 Antibody Epitopeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCenter for Vaccine Research and Infectious Diseases and Microbiology Department. University of Pittsburgh. Pittsburgh, PA, USA.Microbiology and Molecular Genetics Department. University of Pittsburgh. Pittsburgh, PA, USA.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Microbiology and Molecular Genetics Department. University of Pittsburgh. Pittsburgh, PA, USA.Infectious Diseases and Microbiology Department. University of Pittsburgh. Pittsburgh, PA, USA.Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil.Microbiology and Molecular Genetics Department. University of Pittsburgh. Pittsburgh, PA, USA.Suggest new approaches focus on engineer antigenic structures capable of exposing a stable conformation of these epitopes and thus inducing B-cell secretion of HIV-1 pnAbs. We postulated that conformationally stable structures are better immunogens and can elicit the production of better antibodies and results show that MD simulations can help engineer vaccine antigens capable of enhancing protective antibody responses.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83074https://www.arca.fiocruz.br/bitstream/icict/20494/1/license.txt0271fb68963c017aa933c7aff60379f4MD51ORIGINALDE NOVO DESIGN AND BIOPHYSICAL CHARACTERIZATION OF AN AFFINITY-ENHANCED PROTEIN DISPLAYING THE STRUCTURE OF THE BROADLY NEUTRALIZING HIV-1 2F5 ANTIBODY EPITOPE.pdfDE NOVO DESIGN AND BIOPHYSICAL CHARACTERIZATION OF AN AFFINITY-ENHANCED PROTEIN DISPLAYING THE STRUCTURE OF THE BROADLY NEUTRALIZING HIV-1 2F5 ANTIBODY 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dc.title.pt_BR.fl_str_mv De novo design and biophysical characterization of an Affinity-Enhanced Protein displaying the structure of the broadly neutralizing HIV-1 2F5 Antibody Epitope
title De novo design and biophysical characterization of an Affinity-Enhanced Protein displaying the structure of the broadly neutralizing HIV-1 2F5 Antibody Epitope
spellingShingle De novo design and biophysical characterization of an Affinity-Enhanced Protein displaying the structure of the broadly neutralizing HIV-1 2F5 Antibody Epitope
Viana, Isabelle Freire Tabosa
Imunogenicidade da Vacina
HIV-1
HIV Antibodies
Vaccine
VIH-1
Anticuerpos Anti-VIH
Vacunal
HIV-1
Anticorpos Anti-HIV
Vacina
title_short De novo design and biophysical characterization of an Affinity-Enhanced Protein displaying the structure of the broadly neutralizing HIV-1 2F5 Antibody Epitope
title_full De novo design and biophysical characterization of an Affinity-Enhanced Protein displaying the structure of the broadly neutralizing HIV-1 2F5 Antibody Epitope
title_fullStr De novo design and biophysical characterization of an Affinity-Enhanced Protein displaying the structure of the broadly neutralizing HIV-1 2F5 Antibody Epitope
title_full_unstemmed De novo design and biophysical characterization of an Affinity-Enhanced Protein displaying the structure of the broadly neutralizing HIV-1 2F5 Antibody Epitope
title_sort De novo design and biophysical characterization of an Affinity-Enhanced Protein displaying the structure of the broadly neutralizing HIV-1 2F5 Antibody Epitope
author Viana, Isabelle Freire Tabosa
author_facet Viana, Isabelle Freire Tabosa
Nascimento, Eduardo
Krieger, Marco Aurélio
Craigo, Jodi
Mailliard, Robbie
Rafael, Dhalia
Lins, Roberto
Marques, Ernesto T. A.
author_role author
author2 Nascimento, Eduardo
Krieger, Marco Aurélio
Craigo, Jodi
Mailliard, Robbie
Rafael, Dhalia
Lins, Roberto
Marques, Ernesto T. A.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Viana, Isabelle Freire Tabosa
Nascimento, Eduardo
Krieger, Marco Aurélio
Craigo, Jodi
Mailliard, Robbie
Rafael, Dhalia
Lins, Roberto
Marques, Ernesto T. A.
dc.subject.other.pt_BR.fl_str_mv Imunogenicidade da Vacina
topic Imunogenicidade da Vacina
HIV-1
HIV Antibodies
Vaccine
VIH-1
Anticuerpos Anti-VIH
Vacunal
HIV-1
Anticorpos Anti-HIV
Vacina
dc.subject.en.pt_BR.fl_str_mv HIV-1
HIV Antibodies
Vaccine
dc.subject.es.pt_BR.fl_str_mv VIH-1
Anticuerpos Anti-VIH
Vacunal
dc.subject.decs.pt_BR.fl_str_mv HIV-1
Anticorpos Anti-HIV
Vacina
description Center for Vaccine Research and Infectious Diseases and Microbiology Department. University of Pittsburgh. Pittsburgh, PA, USA.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-08-02T16:37:35Z
dc.date.available.fl_str_mv 2017-08-02T16:37:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VIANA, Isabelle Freire Tabosa et al. De Novo Design and Biophysical Characterization of an Affinity-Enhanced Protein Displaying the Structure of the Broadly Neutralizing HIV-1 2F5 Antibody Epitope. Biophysical Journal, v. 110 , n. 3, p. 346a, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20494
dc.identifier.issn.pt_BR.fl_str_mv 0006-3495
dc.identifier.doi.pt_BR.fl_str_mv org/10.1016/j.bpj.2015.11.1860
identifier_str_mv VIANA, Isabelle Freire Tabosa et al. De Novo Design and Biophysical Characterization of an Affinity-Enhanced Protein Displaying the Structure of the Broadly Neutralizing HIV-1 2F5 Antibody Epitope. Biophysical Journal, v. 110 , n. 3, p. 346a, 2016.
0006-3495
org/10.1016/j.bpj.2015.11.1860
url https://www.arca.fiocruz.br/handle/icict/20494
dc.language.iso.fl_str_mv por
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Biophysical Society
publisher.none.fl_str_mv Biophysical Society
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/20494/1/license.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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