Neotropical sylvatic mosquitoes and Aedes aegypti are not competent to transmit 17DD attenuated yellow fever virus from vaccinated viremic new world non-human primates
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/55246 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. |
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Miranda, Rafaella Moraes deFernandes, Rosilainy SurubiFernandes, André Tavares da SilvaBrito, Anielly Ferreira deMoreira, Silvia BahadianPereira, Renata CarvalhoMendes, Ygara da SilvaLima, Sheila Maria Barbosa dePissinatti, AlcidesFreire, Marcos da SilvaAlencar, Jerônimo Augusto FonsecaOliveira, Ricardo Lourenco de2022-10-23T18:33:30Z2022-10-23T18:33:30Z2022MIRANDA, Rafaella Moraes de et al. Neotropical sylvatic mosquitoes and Aedes aegypti are not competent to transmit 17DD attenuated yellow fever virus from vaccinated viremic new world non-human primates. Viruses, v. 14, n. 10, p. 1-10, 11 Oct. 2022.1999-4915https://www.arca.fiocruz.br/handle/icict/5524610.3390/v141022311999-4915engMDPIPrimatas não humanosYF 17DDCompetência vetorialNon-human primatesYF 17DDVector competenceNeotropical sylvatic mosquitoes and Aedes aegypti are not competent to transmit 17DD attenuated yellow fever virus from vaccinated viremic new world non-human primatesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Ambiente. Centro de Primatologia do Rio de Janeiro. Guapimirim, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Ambiente. Centro de Primatologia do Rio de Janeiro. Guapimirim, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Beside humans, thousands of non-human primates (NHPs) died during the recent outbreak caused by the yellow fever virus (YFV) in Brazil. Vaccination of NHPs against YFV with the YF 17DD attenuated virus has emerged as a public health strategy, as it would reduce sylvatic transmission while also preserving endangered susceptible species. The hypothesis of establishing an uncontrolled transmission of this attenuated virus in nature was raised. We assessed vector competence of four sylvatic mosquito species, Haemagogus leucocelaenus, Haemagogus janthinomys/capricornii, Sabethes albiprivus, and Sabethes identicus, as well as the urban vector Aedes aegypti for YF 17DD attenuated vaccine virus when fed directly on eleven viremic lion tamarins or artificially challenged with the same virus. No infection was detected in 689 mosquitoes engorged on viremic lion tamarins whose viremia ranged from 1.05 × 10³ to 6.61 × 10³ FFU/mL, nor in those artificially taking ≤ 1 × 10³ PFU/mL. Low viremia presented by YF 17DD-vaccinated New World NHPs combined with the low capacity and null dissemination ability in sylvatic and domestic mosquitoes of this attenuated virus suggest no risk of its transmission in nature. Thus, vaccination of captive and free-living NHPs against YFV is a safe public health strategy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55246/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRafaelaMiranda_RicardoLourenço_etal_IOC_2022.pdfRafaelaMiranda_RicardoLourenço_etal_IOC_2022.pdfapplication/pdf408186https://www.arca.fiocruz.br/bitstream/icict/55246/2/RafaelaMiranda_RicardoLouren%c3%a7o_etal_IOC_2022.pdf4086cb4a6442f1092a62f57e6df977f1MD52icict/552462023-09-14 15:53:33.335oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-14T18:53:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Neotropical sylvatic mosquitoes and Aedes aegypti are not competent to transmit 17DD attenuated yellow fever virus from vaccinated viremic new world non-human primates |
| title |
Neotropical sylvatic mosquitoes and Aedes aegypti are not competent to transmit 17DD attenuated yellow fever virus from vaccinated viremic new world non-human primates |
| spellingShingle |
Neotropical sylvatic mosquitoes and Aedes aegypti are not competent to transmit 17DD attenuated yellow fever virus from vaccinated viremic new world non-human primates Miranda, Rafaella Moraes de Primatas não humanos YF 17DD Competência vetorial Non-human primates YF 17DD Vector competence |
| title_short |
Neotropical sylvatic mosquitoes and Aedes aegypti are not competent to transmit 17DD attenuated yellow fever virus from vaccinated viremic new world non-human primates |
| title_full |
Neotropical sylvatic mosquitoes and Aedes aegypti are not competent to transmit 17DD attenuated yellow fever virus from vaccinated viremic new world non-human primates |
| title_fullStr |
Neotropical sylvatic mosquitoes and Aedes aegypti are not competent to transmit 17DD attenuated yellow fever virus from vaccinated viremic new world non-human primates |
| title_full_unstemmed |
Neotropical sylvatic mosquitoes and Aedes aegypti are not competent to transmit 17DD attenuated yellow fever virus from vaccinated viremic new world non-human primates |
| title_sort |
Neotropical sylvatic mosquitoes and Aedes aegypti are not competent to transmit 17DD attenuated yellow fever virus from vaccinated viremic new world non-human primates |
| author |
Miranda, Rafaella Moraes de |
| author_facet |
Miranda, Rafaella Moraes de Fernandes, Rosilainy Surubi Fernandes, André Tavares da Silva Brito, Anielly Ferreira de Moreira, Silvia Bahadian Pereira, Renata Carvalho Mendes, Ygara da Silva Lima, Sheila Maria Barbosa de Pissinatti, Alcides Freire, Marcos da Silva Alencar, Jerônimo Augusto Fonseca Oliveira, Ricardo Lourenco de |
| author_role |
author |
| author2 |
Fernandes, Rosilainy Surubi Fernandes, André Tavares da Silva Brito, Anielly Ferreira de Moreira, Silvia Bahadian Pereira, Renata Carvalho Mendes, Ygara da Silva Lima, Sheila Maria Barbosa de Pissinatti, Alcides Freire, Marcos da Silva Alencar, Jerônimo Augusto Fonseca Oliveira, Ricardo Lourenco de |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Miranda, Rafaella Moraes de Fernandes, Rosilainy Surubi Fernandes, André Tavares da Silva Brito, Anielly Ferreira de Moreira, Silvia Bahadian Pereira, Renata Carvalho Mendes, Ygara da Silva Lima, Sheila Maria Barbosa de Pissinatti, Alcides Freire, Marcos da Silva Alencar, Jerônimo Augusto Fonseca Oliveira, Ricardo Lourenco de |
| dc.subject.other.pt_BR.fl_str_mv |
Primatas não humanos YF 17DD Competência vetorial |
| topic |
Primatas não humanos YF 17DD Competência vetorial Non-human primates YF 17DD Vector competence |
| dc.subject.en.en_US.fl_str_mv |
Non-human primates YF 17DD Vector competence |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2022 |
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2022-10-23T18:33:30Z |
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2022-10-23T18:33:30Z |
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2022 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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MIRANDA, Rafaella Moraes de et al. Neotropical sylvatic mosquitoes and Aedes aegypti are not competent to transmit 17DD attenuated yellow fever virus from vaccinated viremic new world non-human primates. Viruses, v. 14, n. 10, p. 1-10, 11 Oct. 2022. |
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https://www.arca.fiocruz.br/handle/icict/55246 |
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1999-4915 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/v14102231 |
| dc.identifier.eissn.none.fl_str_mv |
1999-4915 |
| identifier_str_mv |
MIRANDA, Rafaella Moraes de et al. Neotropical sylvatic mosquitoes and Aedes aegypti are not competent to transmit 17DD attenuated yellow fever virus from vaccinated viremic new world non-human primates. Viruses, v. 14, n. 10, p. 1-10, 11 Oct. 2022. 1999-4915 10.3390/v14102231 |
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MDPI |
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