Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques

Detalhes bibliográficos
Autor(a) principal: Fernandes, Rosilainy Surubi
Data de Publicação: 2020
Outros Autores: David, Mariana Rocha, Abreu, Filipe Vieira Santos de, Brito, Anielly Ferreira de, Gardinali, Noemi R., LIma, Sheila Maria Barbosa, Andrade, Márcia Cristina Ribeiro, Kugelmeier, Tatiana, Oliveira, Jaqueline Mendes de, Pinto, Marcelo A., Oliveira, Ricardo Lourenço de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/45536
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil.
id CRUZ_4ab9116d2f9687ec9d26d5fdfc56ee16
oai_identifier_str oai:www.arca.fiocruz.br:icict/45536
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Fernandes, Rosilainy SurubiDavid, Mariana RochaAbreu, Filipe Vieira Santos deBrito, Anielly Ferreira deGardinali, Noemi R.LIma, Sheila Maria BarbosaAndrade, Márcia Cristina RibeiroKugelmeier, TatianaOliveira, Jaqueline Mendes dePinto, Marcelo A.Oliveira, Ricardo Lourenço de2021-01-07T20:41:51Z2021-01-07T20:41:51Z2020FERNANDES, Rosilainy Surubi et al. Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques. Viruses, v. 12, 1345, 12p, Nov. 2020.1999-4915https://www.arca.fiocruz.br/handle/icict/4553610.3390/v12121345engMDPIZikaPrimatas não humanosMacacos rhesusViremiaCapacidade vetorialTransmissãoNon-human primatesRhesus macaquesZikaViremiaVectorial capacityTransmissionLow Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaquesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos Bio-Manguinhos. Laboratório de Tecnologia Imunológica; Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos Bio-Manguinhos. Laboratório de Tecnologia Imunológica; Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Ciência e Tecnologia em Biomodelos. Serviço de Criação de Primatas não humanos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Ciência e Tecnologia em Biomodelos. Serviço de Criação de Primatas não humanos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil.Despite worldwide e orts to understand the transmission dynamics of Zika virus (ZIKV), scanty evaluation has been made on the vector competence of Aedes aegypti fed directly on viremic human and non-human primates (NHPs). We blood-fed Ae. aegypti from two districts in Rio de Janeiro on six ZIKV infected pregnant rhesus macaques at several time points, half of which were treated with Sofosbuvir (SOF). Mosquitoes were analyzed for vector competence after 3, 7 and 14 days of incubation. Although viremia extended up to eight days post monkey inoculation, only mosquitoes fed on the day of the peak of viremia, recorded on day two, became infected. The influence of SOF treatment could not be assessed because the drug was administered just after mosquito feeding on day two. The global infection, dissemination and transmission rates were quite low (4.09%, 1.91% and 0.54%, respectively); no mosquito was infected when viremia was below 1.26 105 RNA copies/mL. In conclusion, Ae. aegypti vector competence for ZIKV from macaques is low, likely to be due to low viral load and the short duration of ZIKV viremia in primates suitable for infecting susceptible mosquitoes. If ZIKV infection in human and macaques behaves similarly, transmission of the Zika virus in nature is most strongly a ected by vector density.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45536/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALNoemiGardinalli_JaquelineMOliveira_etal_IOC_2020.pdfNoemiGardinalli_JaquelineMOliveira_etal_IOC_2020.pdfapplication/pdf336112https://www.arca.fiocruz.br/bitstream/icict/45536/2/NoemiGardinalli_JaquelineMOliveira_etal_IOC_2020.pdf10eb1e791a21c95888b4c43725d3785dMD52TEXTNoemiGardinalli_JaquelineMOliveira_etal_IOC_2020.pdf.txtNoemiGardinalli_JaquelineMOliveira_etal_IOC_2020.pdf.txtExtracted texttext/plain48438https://www.arca.fiocruz.br/bitstream/icict/45536/3/NoemiGardinalli_JaquelineMOliveira_etal_IOC_2020.pdf.txted0098b0499539e182697caf93396088MD53icict/455362021-01-08 02:04:36.959oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-01-08T05:04:36Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques
title Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques
spellingShingle Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques
Fernandes, Rosilainy Surubi
Zika
Primatas não humanos
Macacos rhesus
Viremia
Capacidade vetorial
Transmissão
Non-human primates
Rhesus macaques
Zika
Viremia
Vectorial capacity
Transmission
title_short Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques
title_full Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques
title_fullStr Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques
title_full_unstemmed Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques
title_sort Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques
author Fernandes, Rosilainy Surubi
author_facet Fernandes, Rosilainy Surubi
David, Mariana Rocha
Abreu, Filipe Vieira Santos de
Brito, Anielly Ferreira de
Gardinali, Noemi R.
LIma, Sheila Maria Barbosa
Andrade, Márcia Cristina Ribeiro
Kugelmeier, Tatiana
Oliveira, Jaqueline Mendes de
Pinto, Marcelo A.
Oliveira, Ricardo Lourenço de
author_role author
author2 David, Mariana Rocha
Abreu, Filipe Vieira Santos de
Brito, Anielly Ferreira de
Gardinali, Noemi R.
LIma, Sheila Maria Barbosa
Andrade, Márcia Cristina Ribeiro
Kugelmeier, Tatiana
Oliveira, Jaqueline Mendes de
Pinto, Marcelo A.
Oliveira, Ricardo Lourenço de
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fernandes, Rosilainy Surubi
David, Mariana Rocha
Abreu, Filipe Vieira Santos de
Brito, Anielly Ferreira de
Gardinali, Noemi R.
LIma, Sheila Maria Barbosa
Andrade, Márcia Cristina Ribeiro
Kugelmeier, Tatiana
Oliveira, Jaqueline Mendes de
Pinto, Marcelo A.
Oliveira, Ricardo Lourenço de
dc.subject.other.pt_BR.fl_str_mv Zika
Primatas não humanos
Macacos rhesus
Viremia
Capacidade vetorial
Transmissão
topic Zika
Primatas não humanos
Macacos rhesus
Viremia
Capacidade vetorial
Transmissão
Non-human primates
Rhesus macaques
Zika
Viremia
Vectorial capacity
Transmission
dc.subject.en.pt_BR.fl_str_mv Non-human primates
Rhesus macaques
Zika
Viremia
Vectorial capacity
Transmission
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-01-07T20:41:51Z
dc.date.available.fl_str_mv 2021-01-07T20:41:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERNANDES, Rosilainy Surubi et al. Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques. Viruses, v. 12, 1345, 12p, Nov. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/45536
dc.identifier.issn.pt_BR.fl_str_mv 1999-4915
dc.identifier.doi.none.fl_str_mv 10.3390/v12121345
identifier_str_mv FERNANDES, Rosilainy Surubi et al. Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques. Viruses, v. 12, 1345, 12p, Nov. 2020.
1999-4915
10.3390/v12121345
url https://www.arca.fiocruz.br/handle/icict/45536
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/45536/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/45536/2/NoemiGardinalli_JaquelineMOliveira_etal_IOC_2020.pdf
https://www.arca.fiocruz.br/bitstream/icict/45536/3/NoemiGardinalli_JaquelineMOliveira_etal_IOC_2020.pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
10eb1e791a21c95888b4c43725d3785d
ed0098b0499539e182697caf93396088
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324856259870720

Registros relacionados