Transcriptomic signatures of alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28000 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ, Brasil. |
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Adesse, DanielIacobas, Dumitru A.Iacobas, SandaGarzoni, Luciana R.Meirelles, Maria de NazarethTanowitz, Herbert B.Spray, David C.2018-08-08T12:36:37Z2018-08-08T12:36:37Z2010ADESSE, Daniel; et al. Transcriptomic signatures of alterations in a myoblast cell line infected with four distinct strains of Trypanosoma Cruzi. Am. J. Trop. Med. Hyg., v.82, n.5, p.846–854, 2010.0002-9637https://www.arca.fiocruz.br/handle/icict/2800010.4269/ajtmh.2010.09-03991476-1645engThe American Society of Tropical Medicine and HygieneTrypanosoma CruziAssinaturas transcriptômicasLinhagem mioblásticaCepasInfecçãoBrasilTrypanosoma CruziTranscriptomic SignaturesMyoblast Cell LineFour Distinct StrainsInfectionBrazilTranscriptomic signatures of alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruziinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ, Brasil.Albert Einstein College of Medicine. Department of Neuroscience. Bronx, NY, USA.Albert Einstein College of Medicine. Department of Neuroscience. Bronx, NY, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ, Brasil..Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ, Brasil.Albert Einstein College of Medicine. Department of Pathology. Bronx, NY, USA.Albert Einstein College of Medicine. Department of Neuroscience. Bronx, NY, USA.We examined the extent to which different Trypanosoma cruzi strains induce transcriptomic changes in cultured L(6)E(9) myoblasts 72 hours after infection with Brazil (TC I), Y (TC II), CL (TC II), and Tulahuen (TC II) strains. Expression of 6,289 distinct, fully annotated unigenes was quantified with 27,000 rat oligonucleotide arrays in each of the four replicas of all control and infected RNA samples. Considering changes greater than 1.5-fold and P values < 0.05, the Tulahuen strain was the most disruptive to host transcriptome (17% significantly altered genes), whereas the Y strain altered only 6% of the genes. The significantly altered genes in the infected cells were largely different among the strains, and only 21 genes were similarly changed by all four strains. However, myoblasts infected with different strains showed proportional overall gene-expression alterations. These results indicate that infection with different parasite strains modulates similar but not identical pathways in the host cells.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28000/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALluciana_garzoni_etal_IOC_2010.pdfluciana_garzoni_etal_IOC_2010.pdfapplication/pdf1402808https://www.arca.fiocruz.br/bitstream/icict/28000/2/luciana_garzoni_etal_IOC_2010.pdf34f41bf2905a301d2bdc74a4d01cf261MD52TEXTluciana_garzoni_etal_IOC_2010.pdf.txtluciana_garzoni_etal_IOC_2010.pdf.txtExtracted texttext/plain43956https://www.arca.fiocruz.br/bitstream/icict/28000/3/luciana_garzoni_etal_IOC_2010.pdf.txt93241d63146d405b9519522abc72b48aMD53icict/280002018-08-15 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| dc.title.pt_BR.fl_str_mv |
Transcriptomic signatures of alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi |
| title |
Transcriptomic signatures of alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi |
| spellingShingle |
Transcriptomic signatures of alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi Adesse, Daniel Trypanosoma Cruzi Assinaturas transcriptômicas Linhagem mioblástica Cepas Infecção Brasil Trypanosoma Cruzi Transcriptomic Signatures Myoblast Cell Line Four Distinct Strains Infection Brazil |
| title_short |
Transcriptomic signatures of alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi |
| title_full |
Transcriptomic signatures of alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi |
| title_fullStr |
Transcriptomic signatures of alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi |
| title_full_unstemmed |
Transcriptomic signatures of alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi |
| title_sort |
Transcriptomic signatures of alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi |
| author |
Adesse, Daniel |
| author_facet |
Adesse, Daniel Iacobas, Dumitru A. Iacobas, Sanda Garzoni, Luciana R. Meirelles, Maria de Nazareth Tanowitz, Herbert B. Spray, David C. |
| author_role |
author |
| author2 |
Iacobas, Dumitru A. Iacobas, Sanda Garzoni, Luciana R. Meirelles, Maria de Nazareth Tanowitz, Herbert B. Spray, David C. |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Adesse, Daniel Iacobas, Dumitru A. Iacobas, Sanda Garzoni, Luciana R. Meirelles, Maria de Nazareth Tanowitz, Herbert B. Spray, David C. |
| dc.subject.other.pt_BR.fl_str_mv |
Trypanosoma Cruzi Assinaturas transcriptômicas Linhagem mioblástica Cepas Infecção Brasil |
| topic |
Trypanosoma Cruzi Assinaturas transcriptômicas Linhagem mioblástica Cepas Infecção Brasil Trypanosoma Cruzi Transcriptomic Signatures Myoblast Cell Line Four Distinct Strains Infection Brazil |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma Cruzi Transcriptomic Signatures Myoblast Cell Line Four Distinct Strains Infection Brazil |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2010 |
| dc.date.issued.fl_str_mv |
2010 |
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2018-08-08T12:36:37Z |
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2018-08-08T12:36:37Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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ADESSE, Daniel; et al. Transcriptomic signatures of alterations in a myoblast cell line infected with four distinct strains of Trypanosoma Cruzi. Am. J. Trop. Med. Hyg., v.82, n.5, p.846–854, 2010. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/28000 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0002-9637 |
| dc.identifier.doi.none.fl_str_mv |
10.4269/ajtmh.2010.09-0399 |
| dc.identifier.eissn.none.fl_str_mv |
1476-1645 |
| identifier_str_mv |
ADESSE, Daniel; et al. Transcriptomic signatures of alterations in a myoblast cell line infected with four distinct strains of Trypanosoma Cruzi. Am. J. Trop. Med. Hyg., v.82, n.5, p.846–854, 2010. 0002-9637 10.4269/ajtmh.2010.09-0399 1476-1645 |
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https://www.arca.fiocruz.br/handle/icict/28000 |
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eng |
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eng |
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openAccess |
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The American Society of Tropical Medicine and Hygiene |
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The American Society of Tropical Medicine and Hygiene |
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