Colonized patients by Candida auris: Third and largest outbreak in Brazil and impact of biofilm formation

Detalhes bibliográficos
Autor(a) principal: Melo, Camylla Carvalho de
Data de Publicação: 2023
Outros Autores: Sousa, Bruna Rodrigues de, Costa, Gisela Lara da, Oliveira, Manoel Marques Evangelista, Lima Neto, Reginaldo Gonçalves de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57499
Resumo: Departamento de Saúde do Estado de Pernambuco. Hospital da Restauração. Recife, PE, Brasil / Universidade Federal de Pernambuco. Centro de Ciências Médicas. Programa de Pós-Graduação em Medicina Tropical. Recife, PE, Brasil.
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network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Melo, Camylla Carvalho deSousa, Bruna Rodrigues deCosta, Gisela Lara daOliveira, Manoel Marques EvangelistaLima Neto, Reginaldo Gonçalves de2023-03-22T14:25:11Z2023-03-22T14:25:11Z2023MELO, Camylla Carvalho de et al. Colonized patients by Candida auris: Third and largest outbreak in Brazil and impact of biofilm formation. Frontiers in Cellular and Infection Microbiology, 13:1033707, p. 1 - 9, Jan. 2023.2235-2988https://www.arca.fiocruz.br/handle/icict/5749910.3389/fcimb.2023.1033707engFrontiers MediaCandida aurisVigilânciaControle de infecçãoBiofilmeSurtoCandida aurisSurveillanceInfection controlBiofilmOutbreakColonized patients by Candida auris: Third and largest outbreak in Brazil and impact of biofilm formationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartamento de Saúde do Estado de Pernambuco. Hospital da Restauração. Recife, PE, Brasil / Universidade Federal de Pernambuco. Centro de Ciências Médicas. Programa de Pós-Graduação em Medicina Tropical. Recife, PE, Brasil.Universidade de Pernambuco. Programa de Pós-Graduação em Biologia Fúngica. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Universidade Federal de Pernambuco. Centro de Ciências Médicas. Programa de Pós-Graduação em Medicina Tropical. Recife, PE, Brasil / Universidade de Pernambuco. Programa de Pós-Graduação em Biologia Fúngica. Recife, PE, Brasil.Objective: To describe the clinical–epidemiological features of patients colonized by Candida auris in the largest outbreak in Brazil and to show the biofilm formation capacity of yeast strains. Methods: Clinical yeasts suspected of C. auris isolated from urine and surveillance samples were seeded on chromogenic media at 30°C and Sabouraud agar at 42°C. matrix-assisted laser desorption/ionization–time of flight mass spectometry was used for reliable identification. After proteomic confirmation, the genomic approach and culture on Chromagar Candida Plus media were carried out. Biofilm formation was investigated based on metabolic activity, and the clinical– epidemiological profile of patients was described. Results: A total of 11 C. auris clinical yeasts from nine patients were identified between the end of December 2021 and March 2022. Two clinical yeasts were isolates from urine and nine clinical yeasts were isolates from axillary and inguinal surveillance swabs. No case is related to previous Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, all the yeasts showed a high ability of biofilm formation. Conclusion: C. auris requires great vigilance as its high capacity to colonize and form biofilms contributes to its dissemination. The rapid and precise identification of this species is essential for the management, control, and prevention of infections.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57499/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALManoelEvangelista_Oliveira_etal_IOC_2023.pdfManoelEvangelista_Oliveira_etal_IOC_2023.pdfapplication/pdf1282734https://www.arca.fiocruz.br/bitstream/icict/57499/2/ManoelEvangelista_Oliveira_etal_IOC_2023.pdf767f645d8906bea1eab677107fd5b3c6MD52icict/574992023-09-04 11:03:07.367oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T14:03:07Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Colonized patients by Candida auris: Third and largest outbreak in Brazil and impact of biofilm formation
title Colonized patients by Candida auris: Third and largest outbreak in Brazil and impact of biofilm formation
spellingShingle Colonized patients by Candida auris: Third and largest outbreak in Brazil and impact of biofilm formation
Melo, Camylla Carvalho de
Candida auris
Vigilância
Controle de infecção
Biofilme
Surto
Candida auris
Surveillance
Infection control
Biofilm
Outbreak
title_short Colonized patients by Candida auris: Third and largest outbreak in Brazil and impact of biofilm formation
title_full Colonized patients by Candida auris: Third and largest outbreak in Brazil and impact of biofilm formation
title_fullStr Colonized patients by Candida auris: Third and largest outbreak in Brazil and impact of biofilm formation
title_full_unstemmed Colonized patients by Candida auris: Third and largest outbreak in Brazil and impact of biofilm formation
title_sort Colonized patients by Candida auris: Third and largest outbreak in Brazil and impact of biofilm formation
author Melo, Camylla Carvalho de
author_facet Melo, Camylla Carvalho de
Sousa, Bruna Rodrigues de
Costa, Gisela Lara da
Oliveira, Manoel Marques Evangelista
Lima Neto, Reginaldo Gonçalves de
author_role author
author2 Sousa, Bruna Rodrigues de
Costa, Gisela Lara da
Oliveira, Manoel Marques Evangelista
Lima Neto, Reginaldo Gonçalves de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Melo, Camylla Carvalho de
Sousa, Bruna Rodrigues de
Costa, Gisela Lara da
Oliveira, Manoel Marques Evangelista
Lima Neto, Reginaldo Gonçalves de
dc.subject.other.en_US.fl_str_mv Candida auris
Vigilância
Controle de infecção
Biofilme
Surto
topic Candida auris
Vigilância
Controle de infecção
Biofilme
Surto
Candida auris
Surveillance
Infection control
Biofilm
Outbreak
dc.subject.en.en_US.fl_str_mv Candida auris
Surveillance
Infection control
Biofilm
Outbreak
description Departamento de Saúde do Estado de Pernambuco. Hospital da Restauração. Recife, PE, Brasil / Universidade Federal de Pernambuco. Centro de Ciências Médicas. Programa de Pós-Graduação em Medicina Tropical. Recife, PE, Brasil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-03-22T14:25:11Z
dc.date.available.fl_str_mv 2023-03-22T14:25:11Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MELO, Camylla Carvalho de et al. Colonized patients by Candida auris: Third and largest outbreak in Brazil and impact of biofilm formation. Frontiers in Cellular and Infection Microbiology, 13:1033707, p. 1 - 9, Jan. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57499
dc.identifier.issn.en_US.fl_str_mv 2235-2988
dc.identifier.doi.none.fl_str_mv 10.3389/fcimb.2023.1033707
identifier_str_mv MELO, Camylla Carvalho de et al. Colonized patients by Candida auris: Third and largest outbreak in Brazil and impact of biofilm formation. Frontiers in Cellular and Infection Microbiology, 13:1033707, p. 1 - 9, Jan. 2023.
2235-2988
10.3389/fcimb.2023.1033707
url https://www.arca.fiocruz.br/handle/icict/57499
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/57499/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/57499/2/ManoelEvangelista_Oliveira_etal_IOC_2023.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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