Candida auris: a quick review on identification, current treatments, and challenges

Detalhes bibliográficos
Autor(a) principal: Cernáková, Lucia
Data de Publicação: 2021
Outros Autores: Roudbary, Maryam, Brás, Susana Maria Pereira, Tafaj, Silva, Rodrigues, Célia F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/72487
Resumo: Candida auris is a novel and major fungal pathogen that has triggered several outbreaks in the last decade. The few drugs available to treat fungal diseases, the fact that this yeast has a high rate of multidrug resistance and the occurrence of misleading identifications, and the ability of forming biofilms (naturally more resistant to drugs) has made treatments of C. auris infections highly difficult. This review intends to quickly illustrate the main issues in C. auris identification, available treatments and the associated mechanisms of resistance, and the novel and alternative treatment and drugs (natural and synthetic) that have been recently reported. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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spelling Candida auris: a quick review on identification, current treatments, and challengesAntifungalBiofilmCandida aurisInfectionNovel therapyResistanceScience & TechnologyCandida auris is a novel and major fungal pathogen that has triggered several outbreaks in the last decade. The few drugs available to treat fungal diseases, the fact that this yeast has a high rate of multidrug resistance and the occurrence of misleading identifications, and the ability of forming biofilms (naturally more resistant to drugs) has made treatments of C. auris infections highly difficult. This review intends to quickly illustrate the main issues in C. auris identification, available treatments and the associated mechanisms of resistance, and the novel and alternative treatment and drugs (natural and synthetic) that have been recently reported. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.L.C. thanks the Slovak Research and Development Agency under contract No. ˇ APVV-15-0347 and the grant of VEGA 1/0537/19 from the Ministry of Education, Science, Research, and the Sport of the Slovak Republic. C.F.R. would like to acknowledge the UID/EQU/00511/2020 Project—Laboratory of Process Engineering, Environment, Biotechnology and Energy (LEPABE)— financed by national funds through FCT/MCTES (PIDDAC).info:eu-repo/semantics/publishedVersionMDPIUniversidade do MinhoCernáková, LuciaRoudbary, MaryamBrás, Susana Maria PereiraTafaj, SilvaRodrigues, Célia F.2021-052021-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/72487engCernáková, L.; Roudbary, M.; Brás, Susana; Tafaj, S.; Rodrigues, Célia F., Candida auris: A quick review on identification, current treatments, and challenges. International Journal of Molecular Sciences, 22(9), 4470, 20211424-67831422-006710.3390/ijms2209447033922907https://www.mdpi.com/1422-0067/22/9/4470info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:10:59Zoai:repositorium.sdum.uminho.pt:1822/72487Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:02:41.290053Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Candida auris: a quick review on identification, current treatments, and challenges
title Candida auris: a quick review on identification, current treatments, and challenges
spellingShingle Candida auris: a quick review on identification, current treatments, and challenges
Cernáková, Lucia
Antifungal
Biofilm
Candida auris
Infection
Novel therapy
Resistance
Science & Technology
title_short Candida auris: a quick review on identification, current treatments, and challenges
title_full Candida auris: a quick review on identification, current treatments, and challenges
title_fullStr Candida auris: a quick review on identification, current treatments, and challenges
title_full_unstemmed Candida auris: a quick review on identification, current treatments, and challenges
title_sort Candida auris: a quick review on identification, current treatments, and challenges
author Cernáková, Lucia
author_facet Cernáková, Lucia
Roudbary, Maryam
Brás, Susana Maria Pereira
Tafaj, Silva
Rodrigues, Célia F.
author_role author
author2 Roudbary, Maryam
Brás, Susana Maria Pereira
Tafaj, Silva
Rodrigues, Célia F.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Cernáková, Lucia
Roudbary, Maryam
Brás, Susana Maria Pereira
Tafaj, Silva
Rodrigues, Célia F.
dc.subject.por.fl_str_mv Antifungal
Biofilm
Candida auris
Infection
Novel therapy
Resistance
Science & Technology
topic Antifungal
Biofilm
Candida auris
Infection
Novel therapy
Resistance
Science & Technology
description Candida auris is a novel and major fungal pathogen that has triggered several outbreaks in the last decade. The few drugs available to treat fungal diseases, the fact that this yeast has a high rate of multidrug resistance and the occurrence of misleading identifications, and the ability of forming biofilms (naturally more resistant to drugs) has made treatments of C. auris infections highly difficult. This review intends to quickly illustrate the main issues in C. auris identification, available treatments and the associated mechanisms of resistance, and the novel and alternative treatment and drugs (natural and synthetic) that have been recently reported. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
publishDate 2021
dc.date.none.fl_str_mv 2021-05
2021-05-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/72487
url http://hdl.handle.net/1822/72487
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cernáková, L.; Roudbary, M.; Brás, Susana; Tafaj, S.; Rodrigues, Célia F., Candida auris: A quick review on identification, current treatments, and challenges. International Journal of Molecular Sciences, 22(9), 4470, 2021
1424-6783
1422-0067
10.3390/ijms22094470
33922907
https://www.mdpi.com/1422-0067/22/9/4470
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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