Inflammasome Activation by CD8D T Cells from Patients with Cutaneous Leishmaniasis Caused by Leishmania braziliensis in the Immunopathogenesis of the Disease

Detalhes bibliográficos
Autor(a) principal: Cardoso, Thiago Marconi
Data de Publicação: 2021
Outros Autores: Lima, Jonilson B., Silva, Icaro Bonyek, Nunes, Sara, Feijó, Daniel, Almeida, Hugo, Silva, Juliana, Barral, Aldina Maria Prado, Oliveira, Viviane Sampaio Boaventura de, Borges, Valéria de Matos, Zamboni, Dario S., Carvalho, Lucas Pedreira de, Carvalho, Edgar Marcelino de, Tavares, Natalia Machado, Brodskyn, Cláudia Ida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46230
Resumo: Fundac¸a˜o de Apoio a Pesquisa do Estado da Bahia (FAPESB), Bahia, Brazil, grant number 05/2015 and Conselho Nacional de Pesquisa (CNPq) grant number 401379/2014-0. DF received a CNPq fellowship (BJT_2014), and HA received a CNPq fellowship for undergraduate students. AB, VMB, EMC, LPC, DSZ, and CB are senior investigators of CNPq.
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spelling Cardoso, Thiago MarconiLima, Jonilson B.Silva, Icaro BonyekNunes, SaraFeijó, DanielAlmeida, HugoSilva, JulianaBarral, Aldina Maria PradoOliveira, Viviane Sampaio Boaventura deBorges, Valéria de MatosZamboni, Dario S.Carvalho, Lucas Pedreira deCarvalho, Edgar Marcelino deTavares, Natalia MachadoBrodskyn, Cláudia Ida2021-03-02T12:46:07Z2021-03-02T12:46:07Z2021CARDOSO, Thiago Marconi et al. Inflammasome Activation by CD8D T Cells from Patients with Cutaneous Leishmaniasis Caused by Leishmania braziliensis in the Immunopathogenesis of the Disease. Journal of Investigative Dermatology, v. 141, p. 209e213, 2021.0022-202Xhttps://www.arca.fiocruz.br/handle/icict/4623010.1016/j.jid.2020.05.106Fundac¸a˜o de Apoio a Pesquisa do Estado da Bahia (FAPESB), Bahia, Brazil, grant number 05/2015 and Conselho Nacional de Pesquisa (CNPq) grant number 401379/2014-0. DF received a CNPq fellowship (BJT_2014), and HA received a CNPq fellowship for undergraduate students. AB, VMB, EMC, LPC, DSZ, and CB are senior investigators of CNPq.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Prof Edgar Santos. Serviço de Imunologia. Salvador, B A, Brasil / Ministério da Ciência e Tecnologia. Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Conselho Nacional de Pesquisa. Salvador, BA, Brasil.Universidade Federal do Oeste da Bahia. Centro de Ciências Biológicas e da Saúde. Barreiras, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospital Universitário Prof Edgar Santos. Serviço de Imunologia. Salvador, B A, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Ministério da Ciência e Tecnologia. Conselho Nacional de Pesquisa. Instituto Nacional de Ciência e Tecnologia de Investigação de Imunologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Prof Edgar Santos. Serviço de Imunologia. Salvador, B A, Brasil / Ministério da Ciência e Tecnologia. Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Conselho Nacional de Pesquisa. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Prof Edgar Santos. Serviço de Imunologia. Salvador, B A, Brasil / Ministério da Ciência e Tecnologia. Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Conselho Nacional de Pesquisa. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Ministério da Ciência e Tecnologia. Conselho Nacional de Pesquisa. Instituto Nacional de Ciência e Tecnologia de Investigação de Imunologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Ministério da Ciência e Tecnologia. Conselho Nacional de Pesquisa. Instituto Nacional de Ciência e Tecnologia de Investigação de Imunologia. São Paulo, SP, Brasil.Cutaneous leishmaniasis (CL) is characterized by an inflammatory response mainly mediated by CD4 þ T cells producing IFN-g, which are responsible for macrophage activation and intracellular Leishmania braziliensis parasite killing. We recently showed the importance of CD8 þ T cells in the pathogenesis of human CL as skin lesions from patients with CL present higher frequencies of CD8 þ T cells, contributing to the inflammatory response.engElsevierInflamassomosLeishmania braziliensisLeishmaniose CutâneaLinfócitos TPacientesInflammasomesLeishmania braziliensisCutaneous LeishmaniasisT lymphocytesPatientsInflammasome Activation by CD8D T Cells from Patients with Cutaneous Leishmaniasis Caused by Leishmania braziliensis in the Immunopathogenesis of the Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/46230/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALCardoso, Thiago Marconi Inflammasome....pdfCardoso, Thiago Marconi 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dc.title.pt_BR.fl_str_mv Inflammasome Activation by CD8D T Cells from Patients with Cutaneous Leishmaniasis Caused by Leishmania braziliensis in the Immunopathogenesis of the Disease
title Inflammasome Activation by CD8D T Cells from Patients with Cutaneous Leishmaniasis Caused by Leishmania braziliensis in the Immunopathogenesis of the Disease
spellingShingle Inflammasome Activation by CD8D T Cells from Patients with Cutaneous Leishmaniasis Caused by Leishmania braziliensis in the Immunopathogenesis of the Disease
Cardoso, Thiago Marconi
Inflamassomos
Leishmania braziliensis
Leishmaniose Cutânea
Linfócitos T
Pacientes
Inflammasomes
Leishmania braziliensis
Cutaneous Leishmaniasis
T lymphocytes
Patients
title_short Inflammasome Activation by CD8D T Cells from Patients with Cutaneous Leishmaniasis Caused by Leishmania braziliensis in the Immunopathogenesis of the Disease
title_full Inflammasome Activation by CD8D T Cells from Patients with Cutaneous Leishmaniasis Caused by Leishmania braziliensis in the Immunopathogenesis of the Disease
title_fullStr Inflammasome Activation by CD8D T Cells from Patients with Cutaneous Leishmaniasis Caused by Leishmania braziliensis in the Immunopathogenesis of the Disease
title_full_unstemmed Inflammasome Activation by CD8D T Cells from Patients with Cutaneous Leishmaniasis Caused by Leishmania braziliensis in the Immunopathogenesis of the Disease
title_sort Inflammasome Activation by CD8D T Cells from Patients with Cutaneous Leishmaniasis Caused by Leishmania braziliensis in the Immunopathogenesis of the Disease
author Cardoso, Thiago Marconi
author_facet Cardoso, Thiago Marconi
Lima, Jonilson B.
Silva, Icaro Bonyek
Nunes, Sara
Feijó, Daniel
Almeida, Hugo
Silva, Juliana
Barral, Aldina Maria Prado
Oliveira, Viviane Sampaio Boaventura de
Borges, Valéria de Matos
Zamboni, Dario S.
Carvalho, Lucas Pedreira de
Carvalho, Edgar Marcelino de
Tavares, Natalia Machado
Brodskyn, Cláudia Ida
author_role author
author2 Lima, Jonilson B.
Silva, Icaro Bonyek
Nunes, Sara
Feijó, Daniel
Almeida, Hugo
Silva, Juliana
Barral, Aldina Maria Prado
Oliveira, Viviane Sampaio Boaventura de
Borges, Valéria de Matos
Zamboni, Dario S.
Carvalho, Lucas Pedreira de
Carvalho, Edgar Marcelino de
Tavares, Natalia Machado
Brodskyn, Cláudia Ida
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cardoso, Thiago Marconi
Lima, Jonilson B.
Silva, Icaro Bonyek
Nunes, Sara
Feijó, Daniel
Almeida, Hugo
Silva, Juliana
Barral, Aldina Maria Prado
Oliveira, Viviane Sampaio Boaventura de
Borges, Valéria de Matos
Zamboni, Dario S.
Carvalho, Lucas Pedreira de
Carvalho, Edgar Marcelino de
Tavares, Natalia Machado
Brodskyn, Cláudia Ida
dc.subject.other.pt_BR.fl_str_mv Inflamassomos
Leishmania braziliensis
Leishmaniose Cutânea
Linfócitos T
Pacientes
topic Inflamassomos
Leishmania braziliensis
Leishmaniose Cutânea
Linfócitos T
Pacientes
Inflammasomes
Leishmania braziliensis
Cutaneous Leishmaniasis
T lymphocytes
Patients
dc.subject.en.pt_BR.fl_str_mv Inflammasomes
Leishmania braziliensis
Cutaneous Leishmaniasis
T lymphocytes
Patients
description Fundac¸a˜o de Apoio a Pesquisa do Estado da Bahia (FAPESB), Bahia, Brazil, grant number 05/2015 and Conselho Nacional de Pesquisa (CNPq) grant number 401379/2014-0. DF received a CNPq fellowship (BJT_2014), and HA received a CNPq fellowship for undergraduate students. AB, VMB, EMC, LPC, DSZ, and CB are senior investigators of CNPq.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-03-02T12:46:07Z
dc.date.available.fl_str_mv 2021-03-02T12:46:07Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARDOSO, Thiago Marconi et al. Inflammasome Activation by CD8D T Cells from Patients with Cutaneous Leishmaniasis Caused by Leishmania braziliensis in the Immunopathogenesis of the Disease. Journal of Investigative Dermatology, v. 141, p. 209e213, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46230
dc.identifier.issn.pt_BR.fl_str_mv 0022-202X
dc.identifier.doi.none.fl_str_mv 10.1016/j.jid.2020.05.106
identifier_str_mv CARDOSO, Thiago Marconi et al. Inflammasome Activation by CD8D T Cells from Patients with Cutaneous Leishmaniasis Caused by Leishmania braziliensis in the Immunopathogenesis of the Disease. Journal of Investigative Dermatology, v. 141, p. 209e213, 2021.
0022-202X
10.1016/j.jid.2020.05.106
url https://www.arca.fiocruz.br/handle/icict/46230
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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