Evolution of anti-Trypanosoma cruzi antibody production in patients with chronic Chagas disease: correlation between antibody titers and development of cardiac disease severity

Detalhes bibliográficos
Autor(a) principal: Georg, Ingebourg
Data de Publicação: 2017
Outros Autores: Hasslocher-Moreno, Alejandro Marcel, Xavier, Sergio Salles, Holanda, Marcelo Teixeira de, Roma, Eric Henrique, Bonecini-Almeida, Maria da Gloria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31879
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Setor de Imunodiagnóstico. Rio de Janeiro, RJ, Brasil.
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spelling Georg, IngebourgHasslocher-Moreno, Alejandro MarcelXavier, Sergio SallesHolanda, Marcelo Teixeira deRoma, Eric HenriqueBonecini-Almeida, Maria da Gloria2019-02-26T14:43:08Z2019-02-26T14:43:08Z2017GEORG, Ingebourg et al. Evolution of anti-Trypanosoma cruzi antibody production in patients with chronic Chagas disease: correlation between antibody titers and development of cardiac disease severity. Plos Neglected Tropical Diseases, p. 1-22, 19 July, 2017.1935-2727https://www.arca.fiocruz.br/handle/icict/3187910.1371/journal.pntd.00057961935-2735engPublic Library of ScienceEvolution of anti-Trypanosoma cruzi antibody production in patients with chronic Chagas disease: correlation between antibody titers and development of cardiac disease severityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Setor de Imunodiagnóstico. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Imunologia e Imunogenética em Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Imunologia e Imunogenética em Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Chagas disease is one of the most important endemic infections in Latin America affecting around 6-7 million people. About 30-50% of patients develop the cardiac form of the disease, which can lead to severe cardiac dysfunction and death. In this scenario, the identification of immunological markers of disease progression would be a valuable tool for early treatment and reduction of death rates. In this observational study, the production of anti-Trypanosoma cruzi antibodies through a retrospective longitudinal follow-up in chronic Chagas disease patients´ cohort and its correlation with disease progression and heart commitment was evaluated. Strong inverse correlation (ρ = -0.6375, p = 0.0005) between anti-T. cruzi IgG1 titers and left ventricular ejection fraction (LVEF) in chronic Chagas cardiomyopathy (CCC) patients were observed after disease progression. Elevated levels of anti-T. cruzi IgG3 titers were detected in all T. cruzi-infected patients, indicating a lack of correlation of this IgG isotype with disease progression. Furthermore, low levels of anti-T. cruzi IgG2, IgG4, and IgA were detected in all patients through the follow-up. Although without statistical significance anti-T. cruzi IgE tends to be more reactive in patients with the indeterminate form (IND) of the disease (p = 0.0637). As this study was conducted in patients with many years of chronic disease no anti-T. cruzi IgM was detected. Taken together, these results indicate that the levels of anti-T. cruzi IgG1 could be considered to seek for promising biomarkers to predict the severity of chronic Chagas disease cardiomyopathy.Trypanosoma cruziChagas diseaseAntibodyCardiac disease severityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31879/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Georg_Ingebourg_etal_INI_2017.pdfve_Georg_Ingebourg_etal_INI_2017.pdfapplication/pdf3250239https://www.arca.fiocruz.br/bitstream/icict/31879/2/ve_Georg_Ingebourg_etal_INI_2017.pdfb99e6a01f4776da5e71a3fe588b87d15MD52TEXTve_Georg_Ingebourg_etal_INI_2017.pdf.txtve_Georg_Ingebourg_etal_INI_2017.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Evolution of anti-Trypanosoma cruzi antibody production in patients with chronic Chagas disease: correlation between antibody titers and development of cardiac disease severity
title Evolution of anti-Trypanosoma cruzi antibody production in patients with chronic Chagas disease: correlation between antibody titers and development of cardiac disease severity
spellingShingle Evolution of anti-Trypanosoma cruzi antibody production in patients with chronic Chagas disease: correlation between antibody titers and development of cardiac disease severity
Georg, Ingebourg
Trypanosoma cruzi
Chagas disease
Antibody
Cardiac disease severity
title_short Evolution of anti-Trypanosoma cruzi antibody production in patients with chronic Chagas disease: correlation between antibody titers and development of cardiac disease severity
title_full Evolution of anti-Trypanosoma cruzi antibody production in patients with chronic Chagas disease: correlation between antibody titers and development of cardiac disease severity
title_fullStr Evolution of anti-Trypanosoma cruzi antibody production in patients with chronic Chagas disease: correlation between antibody titers and development of cardiac disease severity
title_full_unstemmed Evolution of anti-Trypanosoma cruzi antibody production in patients with chronic Chagas disease: correlation between antibody titers and development of cardiac disease severity
title_sort Evolution of anti-Trypanosoma cruzi antibody production in patients with chronic Chagas disease: correlation between antibody titers and development of cardiac disease severity
author Georg, Ingebourg
author_facet Georg, Ingebourg
Hasslocher-Moreno, Alejandro Marcel
Xavier, Sergio Salles
Holanda, Marcelo Teixeira de
Roma, Eric Henrique
Bonecini-Almeida, Maria da Gloria
author_role author
author2 Hasslocher-Moreno, Alejandro Marcel
Xavier, Sergio Salles
Holanda, Marcelo Teixeira de
Roma, Eric Henrique
Bonecini-Almeida, Maria da Gloria
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Georg, Ingebourg
Hasslocher-Moreno, Alejandro Marcel
Xavier, Sergio Salles
Holanda, Marcelo Teixeira de
Roma, Eric Henrique
Bonecini-Almeida, Maria da Gloria
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Chagas disease
Antibody
Cardiac disease severity
topic Trypanosoma cruzi
Chagas disease
Antibody
Cardiac disease severity
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Setor de Imunodiagnóstico. Rio de Janeiro, RJ, Brasil.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2019-02-26T14:43:08Z
dc.date.available.fl_str_mv 2019-02-26T14:43:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GEORG, Ingebourg et al. Evolution of anti-Trypanosoma cruzi antibody production in patients with chronic Chagas disease: correlation between antibody titers and development of cardiac disease severity. Plos Neglected Tropical Diseases, p. 1-22, 19 July, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31879
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0005796
dc.identifier.eissn.none.fl_str_mv 1935-2735
identifier_str_mv GEORG, Ingebourg et al. Evolution of anti-Trypanosoma cruzi antibody production in patients with chronic Chagas disease: correlation between antibody titers and development of cardiac disease severity. Plos Neglected Tropical Diseases, p. 1-22, 19 July, 2017.
1935-2727
10.1371/journal.pntd.0005796
1935-2735
url https://www.arca.fiocruz.br/handle/icict/31879
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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