The benefits of using selenium in the treatment of Chagas disease: prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/26246 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil. |
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Souza, Andréa P. deJelicks, Linda A.Tanowitz, Herbert B.Olivieri, Bianca P.Medeiros, Monica M.Oliveira, Gabriel M.Pires, Andrea Rodrigues CordovilSantos, Alessandro M. dosAraujo-Jorge, Tania C.2018-05-03T15:56:06Z2018-05-03T15:56:06Z2010SOUZA, Andréa P. de; et al. The benefits of using selenium in the treatment of Chagas disease: prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice. Mem Inst Oswaldo Cruz, v. 105, n.6, p.746-751, Sept. 2010.0074-0276https://www.arca.fiocruz.br/handle/icict/262461678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzDoença de ChagasTrypanosoma cruziCardiomiopatiaSelênioseleniumcardiomiopathyChagas DiseaseTrypanosoma cruziThe benefits of using selenium in the treatment of Chagas disease: prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil.Albert Einstein College of Medicine. Department of Physiology and Biophysics. New York, NY, USA.Albert Einstein College of Medicine. Department of Pathology and Medicine. New York, NY, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.Fonte Medicina Diagnóstica. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil.Cardiac damage is a frequent manifestation of Chagas disease, which is caused by the parasite Trypanosoma cruzi. Selenium (Se) is an essential micronutrient, the deficiency of which has been implicated in the development of cardiomyopathy. Our group has previously demonstrated that Se supplementation prevents myocardial damage during acute T. cruzi infection in mice. In this study, we analyzed the effect of Se treatment in cases of T. cruzi infection using prevention and reversion schemes. In the Se prevention scheme, mice were given Se supplements (2 ppm) starting two weeks prior to inoculation with T. cruzi (Brazil strain) and continuing until 120 days post-infection (dpi). In the Se reversion scheme, mice were treated with Se (4 ppm) for 100 days, starting at 160 dpi. Dilatation of the right ventricle was observed in the infected control group at both phases of T. cruzi infection, but it was not observed in the infected group that received Se treatment. Surviving infected mice that were submitted to the Se reversion scheme presented normal P wave values and reduced inflammation of the pericardium. These data indicate that Se treatment prevents right ventricular chamber increase and thus can be proposed as an adjuvant therapy for cardiac alterations already established by T. cruzi infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26246/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALbianca_olivieri_etal_IOC_2011.pdfbianca_olivieri_etal_IOC_2011.pdfapplication/pdf1011562https://www.arca.fiocruz.br/bitstream/icict/26246/2/bianca_olivieri_etal_IOC_2011.pdf49801996b40a43e1b5daf293e937aa4cMD52TEXTbianca_olivieri_etal_IOC_2011.pdf.txtbianca_olivieri_etal_IOC_2011.pdf.txtExtracted texttext/plain32324https://www.arca.fiocruz.br/bitstream/icict/26246/3/bianca_olivieri_etal_IOC_2011.pdf.txt6d8798811e075843a9bdabaa3814b433MD53icict/262462022-06-24 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| dc.title.pt_BR.fl_str_mv |
The benefits of using selenium in the treatment of Chagas disease: prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice |
| title |
The benefits of using selenium in the treatment of Chagas disease: prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice |
| spellingShingle |
The benefits of using selenium in the treatment of Chagas disease: prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice Souza, Andréa P. de Doença de Chagas Trypanosoma cruzi Cardiomiopatia Selênio selenium cardiomiopathy Chagas Disease Trypanosoma cruzi |
| title_short |
The benefits of using selenium in the treatment of Chagas disease: prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice |
| title_full |
The benefits of using selenium in the treatment of Chagas disease: prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice |
| title_fullStr |
The benefits of using selenium in the treatment of Chagas disease: prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice |
| title_full_unstemmed |
The benefits of using selenium in the treatment of Chagas disease: prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice |
| title_sort |
The benefits of using selenium in the treatment of Chagas disease: prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice |
| author |
Souza, Andréa P. de |
| author_facet |
Souza, Andréa P. de Jelicks, Linda A. Tanowitz, Herbert B. Olivieri, Bianca P. Medeiros, Monica M. Oliveira, Gabriel M. Pires, Andrea Rodrigues Cordovil Santos, Alessandro M. dos Araujo-Jorge, Tania C. |
| author_role |
author |
| author2 |
Jelicks, Linda A. Tanowitz, Herbert B. Olivieri, Bianca P. Medeiros, Monica M. Oliveira, Gabriel M. Pires, Andrea Rodrigues Cordovil Santos, Alessandro M. dos Araujo-Jorge, Tania C. |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Souza, Andréa P. de Jelicks, Linda A. Tanowitz, Herbert B. Olivieri, Bianca P. Medeiros, Monica M. Oliveira, Gabriel M. Pires, Andrea Rodrigues Cordovil Santos, Alessandro M. dos Araujo-Jorge, Tania C. |
| dc.subject.other.pt_BR.fl_str_mv |
Doença de Chagas Trypanosoma cruzi Cardiomiopatia Selênio |
| topic |
Doença de Chagas Trypanosoma cruzi Cardiomiopatia Selênio selenium cardiomiopathy Chagas Disease Trypanosoma cruzi |
| dc.subject.en.pt_BR.fl_str_mv |
selenium cardiomiopathy Chagas Disease Trypanosoma cruzi |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil. |
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2010 |
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2010 |
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2018-05-03T15:56:06Z |
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2018-05-03T15:56:06Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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| dc.identifier.citation.fl_str_mv |
SOUZA, Andréa P. de; et al. The benefits of using selenium in the treatment of Chagas disease: prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice. Mem Inst Oswaldo Cruz, v. 105, n.6, p.746-751, Sept. 2010. |
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https://www.arca.fiocruz.br/handle/icict/26246 |
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0074-0276 |
| dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
| identifier_str_mv |
SOUZA, Andréa P. de; et al. The benefits of using selenium in the treatment of Chagas disease: prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice. Mem Inst Oswaldo Cruz, v. 105, n.6, p.746-751, Sept. 2010. 0074-0276 1678-8060 |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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