Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40289 |
Resumo: | Fundação Oswaldo Cruz-Fiocruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil. |
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Cascabulho, Cynthia M.Batista, Marcelo MeuserMoura, Kelly Cristina G. dePinto, Maria do CarmoDuque, Thabata Lopes AlbertoDemarque, Kelly C.Guimarães, Ana Carolina RamosManso, Pedro Paulo de AbreuPelajo-Machado, MarceloOliveira, Gabriel M.Castro, Solange L. deMenna-Barreto, Rubem F. S.2020-03-12T13:50:08Z2020-03-12T13:50:08Z2020CASCABULHO, Cynthia M. et al. Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 115, p. 1-11, 2020.0074-0206https://www.arca.fiocruz.br/handle/icict/4028910.1590/0074-027601903891678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzTrypanosoma cruziDoença de ChagasQuimioterapiaCoraçãoCardiomiopatiaNaftoimidazóisTrypanosoma cruziChagas DiseaseChemotherapyNaphthoimidazolesHeartCardiomiopathyAntiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz-Fiocruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Anatomia Patológica e Citopatologia. Laboratório de Patologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Pesquisa em Produtos Naturais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Pesquisa em Produtos Naturais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.5Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Chagas disease, which is caused by the protozoan Trypanosoma cruzi, is endemic to Latin America and mainly affects low-income populations. Chemotherapy is based on two nitrocompounds, but their reduced efficacy encourages the continuous search for alternative drugs. Our group has characterised the trypanocidal effect of naphthoquinones and their derivatives, with naphthoimidazoles derived from β-lapachone (N1, N2 and N3) being the most active in vitro.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40289/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCynthiaCascabulho_SolangeLCastro_etal_2020.pdfCynthiaCascabulho_SolangeLCastro_etal_2020.pdfapplication/pdf6861128https://www.arca.fiocruz.br/bitstream/icict/40289/2/CynthiaCascabulho_SolangeLCastro_etal_2020.pdfddd9bf1bd96756945dcf120b2b0e98aeMD52TEXTCynthiaCascabulho_SolangeLCastro_etal_2020.pdf.txtCynthiaCascabulho_SolangeLCastro_etal_2020.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection |
| title |
Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection |
| spellingShingle |
Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection Cascabulho, Cynthia M. Trypanosoma cruzi Doença de Chagas Quimioterapia Coração Cardiomiopatia Naftoimidazóis Trypanosoma cruzi Chagas Disease Chemotherapy Naphthoimidazoles Heart Cardiomiopathy |
| title_short |
Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection |
| title_full |
Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection |
| title_fullStr |
Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection |
| title_full_unstemmed |
Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection |
| title_sort |
Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection |
| author |
Cascabulho, Cynthia M. |
| author_facet |
Cascabulho, Cynthia M. Batista, Marcelo Meuser Moura, Kelly Cristina G. de Pinto, Maria do Carmo Duque, Thabata Lopes Alberto Demarque, Kelly C. Guimarães, Ana Carolina Ramos Manso, Pedro Paulo de Abreu Pelajo-Machado, Marcelo Oliveira, Gabriel M. Castro, Solange L. de Menna-Barreto, Rubem F. S. |
| author_role |
author |
| author2 |
Batista, Marcelo Meuser Moura, Kelly Cristina G. de Pinto, Maria do Carmo Duque, Thabata Lopes Alberto Demarque, Kelly C. Guimarães, Ana Carolina Ramos Manso, Pedro Paulo de Abreu Pelajo-Machado, Marcelo Oliveira, Gabriel M. Castro, Solange L. de Menna-Barreto, Rubem F. S. |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cascabulho, Cynthia M. Batista, Marcelo Meuser Moura, Kelly Cristina G. de Pinto, Maria do Carmo Duque, Thabata Lopes Alberto Demarque, Kelly C. Guimarães, Ana Carolina Ramos Manso, Pedro Paulo de Abreu Pelajo-Machado, Marcelo Oliveira, Gabriel M. Castro, Solange L. de Menna-Barreto, Rubem F. S. |
| dc.subject.other.pt_BR.fl_str_mv |
Trypanosoma cruzi Doença de Chagas Quimioterapia Coração Cardiomiopatia Naftoimidazóis |
| topic |
Trypanosoma cruzi Doença de Chagas Quimioterapia Coração Cardiomiopatia Naftoimidazóis Trypanosoma cruzi Chagas Disease Chemotherapy Naphthoimidazoles Heart Cardiomiopathy |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi Chagas Disease Chemotherapy Naphthoimidazoles Heart Cardiomiopathy |
| description |
Fundação Oswaldo Cruz-Fiocruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil. |
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2020 |
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2020-03-12T13:50:08Z |
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2020-03-12T13:50:08Z |
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2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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CASCABULHO, Cynthia M. et al. Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 115, p. 1-11, 2020. |
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https://www.arca.fiocruz.br/handle/icict/40289 |
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0074-0206 |
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10.1590/0074-02760190389 |
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1678-8060 |
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CASCABULHO, Cynthia M. et al. Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 115, p. 1-11, 2020. 0074-0206 10.1590/0074-02760190389 1678-8060 |
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