Nasopharyngeal and Oropharyngeal Colonization by Staphylococcus aureus and Streptococcus pneumoniaeand Prognostic Markers in Children with Sickle Cell Disease from the Northeast of Brazil

Detalhes bibliográficos
Autor(a) principal: Rocha, Larissa Carneiro
Data de Publicação: 2017
Outros Autores: Carvalho, Magda Oliveira Seixas, Nascimento, Valma Maria Lopes de, Santos, Milena Soares dos, Barros, Tania Fraga, Adorno, Elisângela Vitória, Reis, Joice Neves, Guarda, Caroline Conceição da, Santiago, Rayra Pereira, Gonçalves, Marilda de Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25489
Resumo: Brazilian National Council of Research (CNPq) (311888/2013-5) (MdSG); the Foundation Research and Extension of Bahia (FAPESB) (3626/2013, 1431040053063, and 9073/2007) (MdSG); and PPSUS/FAPESB (020/2013 EFP-00007295), (MdSG); the Instituto Nacional de Ciência e Tecnologia do Sangue (CNPq) (Coordinated by S.T.O.S.), and MCD/CNPq/MS-SCTIE-DECIT (409800/2006-6), (MdSG
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spelling Rocha, Larissa CarneiroCarvalho, Magda Oliveira SeixasNascimento, Valma Maria Lopes deSantos, Milena Soares dosBarros, Tania FragaAdorno, Elisângela VitóriaReis, Joice NevesGuarda, Caroline Conceição daSantiago, Rayra PereiraGonçalves, Marilda de Souza2018-03-26T13:18:31Z2018-03-26T13:18:31Z2017ROCHA, Larissa Carneiro et al. Nasopharyngeal and Oropharyngeal Colonization by Staphylococcus aureus and Streptococcus pneumoniae and Prognostic Markers in Children with Sickle Cell Disease from the Northeast of Brazil. Frontiers in Microbiology, v. 8, n. 271, p. 1-10, Feb. 2017.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/2548910.3389/fmicb.2017.00217Brazilian National Council of Research (CNPq) (311888/2013-5) (MdSG); the Foundation Research and Extension of Bahia (FAPESB) (3626/2013, 1431040053063, and 9073/2007) (MdSG); and PPSUS/FAPESB (020/2013 EFP-00007295), (MdSG); the Instituto Nacional de Ciência e Tecnologia do Sangue (CNPq) (Coordinated by S.T.O.S.), and MCD/CNPq/MS-SCTIE-DECIT (409800/2006-6), (MdSGFundação de Hematologia e Hemoterapia da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil.Fundação de Hematologia e Hemoterapia da Bahia. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto Multidisciplinar em Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.We investigated the nasopharynx and oropharynx microbiota in sickle cell disease (SCD) to identify the microorganisms, antibiotic sensitivity, prevalent serotypes, and association of with laboratorial markers. Oropharynx/nasopharynx secretions were investigated in 143 SCD children aging 6 months to 17 years. Pathogens were isolated using standard procedures, and laboratorial markers were performed by automated methods.Staphylococcus aureus(S. aureus) was isolated from nasopharynx and oropharynx of 64 and of 17 SCD children respectively.Streptococcus pneumoniae(S. pneumoniae) was isolated from the nasopharynx and oropharynx of eight SCD patients. Serotypes ofS. pneumoniaewere 19F, 23F, and 14. All isolates were susceptible to penicillin, and patients whose nasopharynx and oropharynx were colonized byS. pneumoniaehad high concentrations of aspartate transaminase, alanine transaminase, and ferritin.S. pneumoniaeisolated were not penicillin-resistant serotypes suggesting that the use of penicillin for prophylaxis and/or treatment of infections is safe. Our finding of colonization and laboratory evaluation in SCD patients suggests that microorganisms are involved in the modulation of chronic inflammatory. The association of colonized microorganisms and laboratorial markers suggest a new approach to these patients follow-up, and additional studies of microorganism colonization and their association with SCD patients' clinical outcome will improve control and prevention strategies.engFrontiers MediaNasofaríngeoOrofaríngeoSorotipoStaphylococcus aureusStreptococcus pneumoniaeNasopharyngealOropharyngealSerotypeStaphylococcus aureusStreptococcus pneumoniaeNasopharyngeal and Oropharyngeal Colonization by Staphylococcus aureus and Streptococcus pneumoniaeand Prognostic Markers in Children with Sickle Cell Disease from the Northeast of Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Nasopharyngeal and Oropharyngeal Colonization by Staphylococcus aureus and Streptococcus pneumoniaeand Prognostic Markers in Children with Sickle Cell Disease from the Northeast of Brazil
title Nasopharyngeal and Oropharyngeal Colonization by Staphylococcus aureus and Streptococcus pneumoniaeand Prognostic Markers in Children with Sickle Cell Disease from the Northeast of Brazil
spellingShingle Nasopharyngeal and Oropharyngeal Colonization by Staphylococcus aureus and Streptococcus pneumoniaeand Prognostic Markers in Children with Sickle Cell Disease from the Northeast of Brazil
Rocha, Larissa Carneiro
Nasofaríngeo
Orofaríngeo
Sorotipo
Staphylococcus aureus
Streptococcus pneumoniae
Nasopharyngeal
Oropharyngeal
Serotype
Staphylococcus aureus
Streptococcus pneumoniae
title_short Nasopharyngeal and Oropharyngeal Colonization by Staphylococcus aureus and Streptococcus pneumoniaeand Prognostic Markers in Children with Sickle Cell Disease from the Northeast of Brazil
title_full Nasopharyngeal and Oropharyngeal Colonization by Staphylococcus aureus and Streptococcus pneumoniaeand Prognostic Markers in Children with Sickle Cell Disease from the Northeast of Brazil
title_fullStr Nasopharyngeal and Oropharyngeal Colonization by Staphylococcus aureus and Streptococcus pneumoniaeand Prognostic Markers in Children with Sickle Cell Disease from the Northeast of Brazil
title_full_unstemmed Nasopharyngeal and Oropharyngeal Colonization by Staphylococcus aureus and Streptococcus pneumoniaeand Prognostic Markers in Children with Sickle Cell Disease from the Northeast of Brazil
title_sort Nasopharyngeal and Oropharyngeal Colonization by Staphylococcus aureus and Streptococcus pneumoniaeand Prognostic Markers in Children with Sickle Cell Disease from the Northeast of Brazil
author Rocha, Larissa Carneiro
author_facet Rocha, Larissa Carneiro
Carvalho, Magda Oliveira Seixas
Nascimento, Valma Maria Lopes de
Santos, Milena Soares dos
Barros, Tania Fraga
Adorno, Elisângela Vitória
Reis, Joice Neves
Guarda, Caroline Conceição da
Santiago, Rayra Pereira
Gonçalves, Marilda de Souza
author_role author
author2 Carvalho, Magda Oliveira Seixas
Nascimento, Valma Maria Lopes de
Santos, Milena Soares dos
Barros, Tania Fraga
Adorno, Elisângela Vitória
Reis, Joice Neves
Guarda, Caroline Conceição da
Santiago, Rayra Pereira
Gonçalves, Marilda de Souza
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rocha, Larissa Carneiro
Carvalho, Magda Oliveira Seixas
Nascimento, Valma Maria Lopes de
Santos, Milena Soares dos
Barros, Tania Fraga
Adorno, Elisângela Vitória
Reis, Joice Neves
Guarda, Caroline Conceição da
Santiago, Rayra Pereira
Gonçalves, Marilda de Souza
dc.subject.other.pt_BR.fl_str_mv Nasofaríngeo
Orofaríngeo
Sorotipo
Staphylococcus aureus
Streptococcus pneumoniae
topic Nasofaríngeo
Orofaríngeo
Sorotipo
Staphylococcus aureus
Streptococcus pneumoniae
Nasopharyngeal
Oropharyngeal
Serotype
Staphylococcus aureus
Streptococcus pneumoniae
dc.subject.en.pt_BR.fl_str_mv Nasopharyngeal
Oropharyngeal
Serotype
Staphylococcus aureus
Streptococcus pneumoniae
description Brazilian National Council of Research (CNPq) (311888/2013-5) (MdSG); the Foundation Research and Extension of Bahia (FAPESB) (3626/2013, 1431040053063, and 9073/2007) (MdSG); and PPSUS/FAPESB (020/2013 EFP-00007295), (MdSG); the Instituto Nacional de Ciência e Tecnologia do Sangue (CNPq) (Coordinated by S.T.O.S.), and MCD/CNPq/MS-SCTIE-DECIT (409800/2006-6), (MdSG
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-03-26T13:18:31Z
dc.date.available.fl_str_mv 2018-03-26T13:18:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ROCHA, Larissa Carneiro et al. Nasopharyngeal and Oropharyngeal Colonization by Staphylococcus aureus and Streptococcus pneumoniae and Prognostic Markers in Children with Sickle Cell Disease from the Northeast of Brazil. Frontiers in Microbiology, v. 8, n. 271, p. 1-10, Feb. 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25489
dc.identifier.issn.pt_BR.fl_str_mv 1664-302X
dc.identifier.doi.none.fl_str_mv 10.3389/fmicb.2017.00217
identifier_str_mv ROCHA, Larissa Carneiro et al. Nasopharyngeal and Oropharyngeal Colonization by Staphylococcus aureus and Streptococcus pneumoniae and Prognostic Markers in Children with Sickle Cell Disease from the Northeast of Brazil. Frontiers in Microbiology, v. 8, n. 271, p. 1-10, Feb. 2017.
1664-302X
10.3389/fmicb.2017.00217
url https://www.arca.fiocruz.br/handle/icict/25489
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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