Low Prevalence of Transmitted HIV-1 Antiretroviral Resistance in Pregnant Women from Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Couto-Fernandez, Jose Carlos
Data de Publicação: 2022
Outros Autores: Jesus, Carlos Silva de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58915
Resumo: Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de AIDS e Imunologia Molecular, Centro de Referência da OMS para Vigilância da Resistência do HIV-1 (HIVResNet). Rio de Janeiro-RJ, Brasil.
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spelling Couto-Fernandez, Jose CarlosJesus, Carlos Silva de2023-06-03T13:14:48Z2023-06-03T13:14:48Z2022Couto-Fernandez, José Carlos; JESUS, Carlos Silva de. Low Prevalence of Transmitted HIV-1 Antiretroviral Resistance in Pregnant Women from Rio de Janeiro, Brazil. Low Prevalence of Transmitted HIV-1 Antiretroviral Resistance in Pregnant Women from Rio de Janeiro, Brazil. J. Biomed Res. Environ. Sci. Sep 15; 3(9): p. 1054-1056, 2022.2766-2276https://www.arca.fiocruz.br/handle/icict/5891510.37871/jbres1554engMedicine GroupBaixa Prevalência de HIV-1 TransmitidoResistência aos antirretroviraisGestantesLow Prevalence of Transmitted HIV-1Antiretroviral Resistance in Pregnant WomenLow Prevalence of Transmitted HIV-1 Antiretroviral Resistance in Pregnant Women from Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de AIDS e Imunologia Molecular, Centro de Referência da OMS para Vigilância da Resistência do HIV-1 (HIVResNet). Rio de Janeiro-RJ, Brasil.Sem afiliaçãoBackground: HIV screening during antenatal care is being expanded in Brazil for early diagnosis of HIV-1 infection during pregnancy and prevention of vertical transmission. HIV genotyping in pregnant women is crucial to reduce the risk of vertical transmission in those carrying resistant strains and may also be used for Transmitted Drug Resistance (TDR) surveillance purpose. We evaluated prevalence and patterns of HIV-1 TDR and HIV-1 subtype distribution, in recently diagnosed ARV naïve pregnant women from Rio de Janeiro, Brazil. Methods: 299 blood samples of recently diagnosed HIV-1-infected pregnant women from four reference antenatal care public health units in Rio de Janeiro, were consecutively collected and analyzed from 2005 to 2015. ViroseqTM (Abbott) and TrugeneTM HIV-1 Genotyping Systems (Siemens) were used for genotyping and the Standford Algorithm for Interpretation of HIV-1 Resistance for TDR and subtype identifi cation. Results: The most prevalent HIV-1 subtype was the subtype B (79.3%), followed by subtype F (11.9%), BF recombinant forms (4%), subtype C (2%) and the recombinant forms: CRF02_AG, CRF31_ BC, K/F and DF identifi ed in one subject each. Overall, the associated resistance mutations were 12.6%, 4.3% associated to the Nucleoside Reverse Transcriptase Inhibitors (NRTIs) of the samples, 4.9% to Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) and 3.4% to Protease Inhibitors (PIs). Mutations associated with NRTI resistance were TAMs, F77L, M184V; associated with NNRTI resistance were K103N, Y188H and L100I and mutations associated to PIs were D30N, M46I, and V82L. Conclusion: HIV-1 subtype B was the most prevalent subtype observed in our study. For the fi rst time infections with the circulating recombinant forms CRF02_AG and CRF31_BC were described in a pregnant woman, suggesting the spread of African derived virus in Brazil and the introduction in Rio de Janeiro of the CRF31_BC coming from South Brazil. Our results strongly suggest the need of establishing a regular surveillance system for transmitted HIV-1 drug resistance in pregnant women in Brazil and its integration in antenatal care management policies for HIV-1 infected women should be considered.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58915/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJoseFernandez_CarlosJesus_IOC_2022.pdfJoseFernandez_CarlosJesus_IOC_2022.pdfapplication/pdf473223https://www.arca.fiocruz.br/bitstream/icict/58915/2/JoseFernandez_CarlosJesus_IOC_2022.pdf5987e4e35725254d9658f0928700ae42MD52icict/589152023-09-04 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dc.title.en_US.fl_str_mv Low Prevalence of Transmitted HIV-1 Antiretroviral Resistance in Pregnant Women from Rio de Janeiro, Brazil
title Low Prevalence of Transmitted HIV-1 Antiretroviral Resistance in Pregnant Women from Rio de Janeiro, Brazil
spellingShingle Low Prevalence of Transmitted HIV-1 Antiretroviral Resistance in Pregnant Women from Rio de Janeiro, Brazil
Couto-Fernandez, Jose Carlos
Baixa Prevalência de HIV-1 Transmitido
Resistência aos antirretrovirais
Gestantes
Low Prevalence of Transmitted HIV-1
Antiretroviral Resistance in Pregnant Women
title_short Low Prevalence of Transmitted HIV-1 Antiretroviral Resistance in Pregnant Women from Rio de Janeiro, Brazil
title_full Low Prevalence of Transmitted HIV-1 Antiretroviral Resistance in Pregnant Women from Rio de Janeiro, Brazil
title_fullStr Low Prevalence of Transmitted HIV-1 Antiretroviral Resistance in Pregnant Women from Rio de Janeiro, Brazil
title_full_unstemmed Low Prevalence of Transmitted HIV-1 Antiretroviral Resistance in Pregnant Women from Rio de Janeiro, Brazil
title_sort Low Prevalence of Transmitted HIV-1 Antiretroviral Resistance in Pregnant Women from Rio de Janeiro, Brazil
author Couto-Fernandez, Jose Carlos
author_facet Couto-Fernandez, Jose Carlos
Jesus, Carlos Silva de
author_role author
author2 Jesus, Carlos Silva de
author2_role author
dc.contributor.author.fl_str_mv Couto-Fernandez, Jose Carlos
Jesus, Carlos Silva de
dc.subject.other.en_US.fl_str_mv Baixa Prevalência de HIV-1 Transmitido
Resistência aos antirretrovirais
Gestantes
topic Baixa Prevalência de HIV-1 Transmitido
Resistência aos antirretrovirais
Gestantes
Low Prevalence of Transmitted HIV-1
Antiretroviral Resistance in Pregnant Women
dc.subject.en.en_US.fl_str_mv Low Prevalence of Transmitted HIV-1
Antiretroviral Resistance in Pregnant Women
description Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de AIDS e Imunologia Molecular, Centro de Referência da OMS para Vigilância da Resistência do HIV-1 (HIVResNet). Rio de Janeiro-RJ, Brasil.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-06-03T13:14:48Z
dc.date.available.fl_str_mv 2023-06-03T13:14:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Couto-Fernandez, José Carlos; JESUS, Carlos Silva de. Low Prevalence of Transmitted HIV-1 Antiretroviral Resistance in Pregnant Women from Rio de Janeiro, Brazil. Low Prevalence of Transmitted HIV-1 Antiretroviral Resistance in Pregnant Women from Rio de Janeiro, Brazil. J. Biomed Res. Environ. Sci. Sep 15; 3(9): p. 1054-1056, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58915
dc.identifier.issn.en_US.fl_str_mv 2766-2276
dc.identifier.doi.none.fl_str_mv 10.37871/jbres1554
identifier_str_mv Couto-Fernandez, José Carlos; JESUS, Carlos Silva de. Low Prevalence of Transmitted HIV-1 Antiretroviral Resistance in Pregnant Women from Rio de Janeiro, Brazil. Low Prevalence of Transmitted HIV-1 Antiretroviral Resistance in Pregnant Women from Rio de Janeiro, Brazil. J. Biomed Res. Environ. Sci. Sep 15; 3(9): p. 1054-1056, 2022.
2766-2276
10.37871/jbres1554
url https://www.arca.fiocruz.br/handle/icict/58915
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Medicine Group
publisher.none.fl_str_mv Medicine Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/58915/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/58915/2/JoseFernandez_CarlosJesus_IOC_2022.pdf
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