Long non-coding RNAs are differentially expressed after different exercise training programs

Detalhes bibliográficos
Autor(a) principal: Bonilauri, Bernardo
Data de Publicação: 2020
Outros Autores: Dallagiovanna, Bruno
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44549
Resumo: Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.
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spelling Bonilauri, BernardoDallagiovanna, Bruno2020-11-19T18:48:53Z2020-11-19T18:48:53Z2020BONILAURI, Bernardo; DALLAGIOVANNA, Bruno. Long non-coding RNAs are differentially expressed after different exercise training programs. Front. Physiol. V.11, n. 567614, p. 1-10, 2020.1664-042Xhttps://www.arca.fiocruz.br/handle/icict/4454910.3389/fphys.2020.567614porFrontiers MediaLong non-coding RNAs are differentially expressed after different exercise training programsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Molecular regulation related to the health benefits of different exercise modes remains unclear. Long non-coding RNAs (lncRNAs) have emerged as an RNA class with regulatory functions in health and diseases. Here, we analyzed the expression. of lncRNAs after different exercise training programs and their possible modes of action related to physical exercise adaptations. As methods: Public high-throughput RNA-seq data (skeletal muscle biopsies) were downloaded, and bioinformatics analysis was performed. We primarily analyzed data reports of 12 weeks of resistance training (RT), high-intensity interval training (HIIT), and combined (CT) exercise training. In addition, we analyzed data from 8 weeks of endurance training (ET). Differential expression analysis of lncRNAs was performed, and an adjusted P-value < 0.1 and log2 (fold change) ≥0.5 or ≤−0.5 were set as the cutoff values to identify differentially expressed lncRNAs (DELs). In the results: We identified 204 DELs after 12 weeks of HIIT, 43 DELs after RT, and 15 DELs after CT. Moreover, 52 lncRNAs were differentially expressed after 8 weeks of ET. The lncRNA expression pattern after physical exercise was very specific, with distinct expression profiles for the different training programs, where few lncRNAs were common among the exercise types. LncRNAs may regulate molecular responses to exercise, such as collagen fibril organization, extracellular matrix organization, myoblast and plasma membrane fusion, skeletal muscle contraction, synaptic transmission, PI3K and TORC regulation, autophagy, and angiogenesis. Conclusion: For the first time, we show that lncRNAs are differentially expressed in skeletal muscle after different physical exercise programs, and these lncRNAs may act in various biological processes related to physical activity adaptations.RNA Longo não CodificantelncRNAsExercisePhysical Conditioning, HumanMusclesHIITHigh-Intensity Interval TrainingARN Largo no CodificanteEjercicio FísicoAcondicionamiento Físico HumanoEntrenamiento de Intervalos de Alta IntensidadARN long non codantExercice physiqueMise en condition physique de l'hommeEntrainement fractionné de haute intensitéRNA Longo não CodificanteExercício FísicoCondicionamento Físico HumanoRNA-SeqMúsculosTreinamento Intervalado de Alta Intensidadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Long non-coding RNAs are differentially expressed after different exercise training programs
title Long non-coding RNAs are differentially expressed after different exercise training programs
spellingShingle Long non-coding RNAs are differentially expressed after different exercise training programs
Bonilauri, Bernardo
RNA Longo não Codificante
lncRNAs
Exercise
Physical Conditioning, Human
Muscles
HIIT
High-Intensity Interval Training
ARN Largo no Codificante
Ejercicio Físico
Acondicionamiento Físico Humano
Entrenamiento de Intervalos de Alta Intensidad
ARN long non codant
Exercice physique
Mise en condition physique de l'homme
Entrainement fractionné de haute intensité
RNA Longo não Codificante
Exercício Físico
Condicionamento Físico Humano
RNA-Seq
Músculos
Treinamento Intervalado de Alta Intensidade
title_short Long non-coding RNAs are differentially expressed after different exercise training programs
title_full Long non-coding RNAs are differentially expressed after different exercise training programs
title_fullStr Long non-coding RNAs are differentially expressed after different exercise training programs
title_full_unstemmed Long non-coding RNAs are differentially expressed after different exercise training programs
title_sort Long non-coding RNAs are differentially expressed after different exercise training programs
author Bonilauri, Bernardo
author_facet Bonilauri, Bernardo
Dallagiovanna, Bruno
author_role author
author2 Dallagiovanna, Bruno
author2_role author
dc.contributor.author.fl_str_mv Bonilauri, Bernardo
Dallagiovanna, Bruno
dc.subject.en.pt_BR.fl_str_mv RNA Longo não Codificante
lncRNAs
Exercise
Physical Conditioning, Human
Muscles
HIIT
High-Intensity Interval Training
topic RNA Longo não Codificante
lncRNAs
Exercise
Physical Conditioning, Human
Muscles
HIIT
High-Intensity Interval Training
ARN Largo no Codificante
Ejercicio Físico
Acondicionamiento Físico Humano
Entrenamiento de Intervalos de Alta Intensidad
ARN long non codant
Exercice physique
Mise en condition physique de l'homme
Entrainement fractionné de haute intensité
RNA Longo não Codificante
Exercício Físico
Condicionamento Físico Humano
RNA-Seq
Músculos
Treinamento Intervalado de Alta Intensidade
dc.subject.es.pt_BR.fl_str_mv ARN Largo no Codificante
Ejercicio Físico
Acondicionamiento Físico Humano
Entrenamiento de Intervalos de Alta Intensidad
dc.subject.fr.pt_BR.fl_str_mv ARN long non codant
Exercice physique
Mise en condition physique de l'homme
Entrainement fractionné de haute intensité
dc.subject.decs.pt_BR.fl_str_mv RNA Longo não Codificante
Exercício Físico
Condicionamento Físico Humano
RNA-Seq
Músculos
Treinamento Intervalado de Alta Intensidade
description Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-11-19T18:48:53Z
dc.date.available.fl_str_mv 2020-11-19T18:48:53Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BONILAURI, Bernardo; DALLAGIOVANNA, Bruno. Long non-coding RNAs are differentially expressed after different exercise training programs. Front. Physiol. V.11, n. 567614, p. 1-10, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44549
dc.identifier.issn.pt_BR.fl_str_mv 1664-042X
dc.identifier.doi.none.fl_str_mv 10.3389/fphys.2020.567614
identifier_str_mv BONILAURI, Bernardo; DALLAGIOVANNA, Bruno. Long non-coding RNAs are differentially expressed after different exercise training programs. Front. Physiol. V.11, n. 567614, p. 1-10, 2020.
1664-042X
10.3389/fphys.2020.567614
url https://www.arca.fiocruz.br/handle/icict/44549
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/44549/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/44549/2/fphys567614OK.pdf
https://www.arca.fiocruz.br/bitstream/icict/44549/3/fphys567614OK.pdf.txt
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bitstream.checksumAlgorithm.fl_str_mv MD5
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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