Microproteins in skeletal muscle: hidden keys in muscle physiology

Detalhes bibliográficos
Autor(a) principal: Bonilauri, Bernardo
Data de Publicação: 2021
Outros Autores: Dallagiovanna, Bruno
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50343
Resumo: Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.
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spelling Bonilauri, BernardoDallagiovanna, Bruno2021-12-13T17:24:50Z2021-12-13T17:24:50Z2021BONILAURI, Bernardo et al. Microproteins in skeletal muscle: hidden keys in muscle physiology. Journal of Cachexia, Sarcopenia and Muscle, p. 1–14, 2021.2190-6009https://www.arca.fiocruz.br/handle/icict/5034310.1002/jcsm.12866porWiley Open AccessMicroproteínasMicroproteinsRNA, Long NoncodingOpen Reading FramesMuscle DevelopmentARN Largo no CodificanteSistemas de Lectura AbiertaDesarrollo de MúsculosARN long non codantCadres ouverts de lectureDéveloppement musculaireRNA Longo não CodificanteFases de Leitura AbertaDesenvolvimento MuscularMicroproteins in skeletal muscle: hidden keys in muscle physiologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Recent advances in the transcriptomics, translatomics, and proteomics have led us to the exciting new world of functional endogenous microproteins. These microproteins have a small size and are derived from small open reading frames (smORFs) of RNAs previously annotated as non-coding (e.g. lncRNAs and circRNAs) as well as from untranslated regions and canonical mRNAs. The presence of these microproteins reveals a much larger translatable portion of the genome, shifting previously defined dogmas and paradigms. These findings affect our view of organisms as a whole, including skeletal muscle tissue. Emerging evidence demonstrates that several smORF-derived microproteins play crucial roles during muscle development (myogenesis), maintenance, and regeneration, as well as lipid and glucose metabolism and skeletal muscle bioenergetics. These microproteins are also involved in processes including physical activity capacity, cellular stress, and muscular-related diseases (i.e. myopathy, cachexia, atrophy, and muscle wasting). Given the role of these small proteins as important key regulators of several skeletal muscle processes, there are rich prospects for the discovery of new microproteins and possible therapies using synthetic microproteins.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/50343/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALjcsm.12866ok.pdfjcsm.12866ok.pdfapplication/pdf647807https://www.arca.fiocruz.br/bitstream/icict/50343/2/jcsm.12866ok.pdf02b1d454ef2ee8a2c08bd2630c87a4fcMD52icict/503432021-12-13 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dc.title.pt_BR.fl_str_mv Microproteins in skeletal muscle: hidden keys in muscle physiology
title Microproteins in skeletal muscle: hidden keys in muscle physiology
spellingShingle Microproteins in skeletal muscle: hidden keys in muscle physiology
Bonilauri, Bernardo
Microproteínas
Microproteins
RNA, Long Noncoding
Open Reading Frames
Muscle Development
ARN Largo no Codificante
Sistemas de Lectura Abierta
Desarrollo de Músculos
ARN long non codant
Cadres ouverts de lecture
Développement musculaire
RNA Longo não Codificante
Fases de Leitura Aberta
Desenvolvimento Muscular
title_short Microproteins in skeletal muscle: hidden keys in muscle physiology
title_full Microproteins in skeletal muscle: hidden keys in muscle physiology
title_fullStr Microproteins in skeletal muscle: hidden keys in muscle physiology
title_full_unstemmed Microproteins in skeletal muscle: hidden keys in muscle physiology
title_sort Microproteins in skeletal muscle: hidden keys in muscle physiology
author Bonilauri, Bernardo
author_facet Bonilauri, Bernardo
Dallagiovanna, Bruno
author_role author
author2 Dallagiovanna, Bruno
author2_role author
dc.contributor.author.fl_str_mv Bonilauri, Bernardo
Dallagiovanna, Bruno
dc.subject.other.pt_BR.fl_str_mv Microproteínas
topic Microproteínas
Microproteins
RNA, Long Noncoding
Open Reading Frames
Muscle Development
ARN Largo no Codificante
Sistemas de Lectura Abierta
Desarrollo de Músculos
ARN long non codant
Cadres ouverts de lecture
Développement musculaire
RNA Longo não Codificante
Fases de Leitura Aberta
Desenvolvimento Muscular
dc.subject.en.pt_BR.fl_str_mv Microproteins
RNA, Long Noncoding
Open Reading Frames
Muscle Development
dc.subject.es.pt_BR.fl_str_mv ARN Largo no Codificante
Sistemas de Lectura Abierta
Desarrollo de Músculos
dc.subject.fr.pt_BR.fl_str_mv ARN long non codant
Cadres ouverts de lecture
Développement musculaire
dc.subject.decs.pt_BR.fl_str_mv RNA Longo não Codificante
Fases de Leitura Aberta
Desenvolvimento Muscular
description Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-13T17:24:50Z
dc.date.available.fl_str_mv 2021-12-13T17:24:50Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BONILAURI, Bernardo et al. Microproteins in skeletal muscle: hidden keys in muscle physiology. Journal of Cachexia, Sarcopenia and Muscle, p. 1–14, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50343
dc.identifier.issn.pt_BR.fl_str_mv 2190-6009
dc.identifier.doi.none.fl_str_mv 10.1002/jcsm.12866
identifier_str_mv BONILAURI, Bernardo et al. Microproteins in skeletal muscle: hidden keys in muscle physiology. Journal of Cachexia, Sarcopenia and Muscle, p. 1–14, 2021.
2190-6009
10.1002/jcsm.12866
url https://www.arca.fiocruz.br/handle/icict/50343
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley Open Access
publisher.none.fl_str_mv Wiley Open Access
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50343/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50343/2/jcsm.12866ok.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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