Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil

Detalhes bibliográficos
Autor(a) principal: Castanha, Priscila M. S.
Data de Publicação: 2019
Outros Autores: Souza, Wayner V., Braga, Cynthia, Araújo, Thália Velho Barreto de, Ximenes, Ricardo A. A., Albuquerque, Maria de Fátima P. M., Montarroyos, Ulisses R., Miranda-Filho, Demócrito B., Cordeiro, Marli T., Dhalia, Rafael, Marques, Ernesto T. A., Rodrigues, Laura C., Martelli, Celina M. T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36040
Resumo: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Universidade de Pernambuco. Faculdade de Ciências Médicas. Recife, PE, Brasil.
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spelling Castanha, Priscila M. S.Souza, Wayner V.Braga, CynthiaAraújo, Thália Velho Barreto deXimenes, Ricardo A. A.Albuquerque, Maria de Fátima P. M.Montarroyos, Ulisses R.Miranda-Filho, Demócrito B.Cordeiro, Marli T.Dhalia, RafaelMarques, Ernesto T. A.Rodrigues, Laura C.Martelli, Celina M. T.2019-10-01T14:52:03Z2019-10-01T14:52:03Z2019CASTANHA, Priscila M. S. et al. Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil. PLoS Neglected Tropical Diseases, v. 13, n. 3, p. 1-17, 2019.1935-2727https://www.arca.fiocruz.br/handle/icict/3604010.1371/journal.pntd.00072461935-2735engPerinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Universidade de Pernambuco. Faculdade de Ciências Médicas. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Universidade Federal de Pernambuco. Recife, PE, Brasil.Universidade de Pernambuco. Faculdade de Ciências Médicas. Recife, PE, Brasil / Universidade Federal de Pernambuco. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Universidade de Pernambuco. Faculdade de Ciências Médicas. Recife, PE, Brasil.Universidade de Pernambuco. Faculdade de Ciências Médicas. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / University of Pittsburgh. Department of Infectious Diseases and Microbiology. Pittsburgh, Pennsylvania, United States of America.London School of Hygiene & Tropical Medicine. Department of Infectious Disease Epidemiology. London, United Kingdom.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Laboratory confirmation of Zika virus (ZIKV) infection during pregnancy is challenging due to cross-reactivity with dengue virus (DENV) and limited knowledge about the kinetics of anti-Zika antibody responses during pregnancy. We described ZIKV and DENV serological markers and the maternal-fetal transfer of antibodies among mothers and neonates after the ZIKV microcephaly outbreak in Northeast Brazil (2016). We included 89 microcephaly cases and 173 neonate controls at time of birth and their mothers. Microcephaly cases were defined as newborns with a particular head circumference (2 SD below the mean). Two controls without microcephaly were matched by the expected date of delivery and area of residence. We tested maternal serum for recent (ZIKV genome, IgM and IgG3 anti-NS1) and previous (ZIKV and DENV neutralizing antibodies [NAbs]) markers of infection. Multiple markers of recent or previous ZIKV and DENV infection in mothers were analyzed using principal component analysis (PCA). At delivery, 5.6% of microcephaly case mothers and 1.7% of control mothers were positive for ZIKV IgM. Positivity for ZIKV IgG3 anti-NS1 was 8.0% for case mothers and 3.5% for control mothers. ZIKV NAbs was slightly higher among mothers of cases (69.6%) than that of mothers of controls (57.2%; p = 0.054). DENV exposure was detected in 85.8% of all mothers. PCA discriminated two distinct components related to recent or previous ZIKV infection and DENV exposure. ZIKV NAbs were higher in newborns than in their corresponding mothers (p<0.001). We detected a high frequency of ZIKV exposure among mothers after the first wave of the ZIKV outbreak in Northeast Brazil. However, we found low sensitivity of the serological markers to recent infection (IgM and IgG3 anti-NS1) in perinatal samples of mothers of microcephaly cases. Since the neutralization test cannot precisely determine the time of infection, testing for ZIKV immune status should be performed as early as possible and throughout pregnancy to monitor acute Zika infection in endemic areas.ZikaDengueMicrocephalyInfectionAdolescenteAdultoAnticorpos Neutralizantes / sangueAnticorpos Antivirais / sangueBrasil / epidemiologiaEstudos de Casos e ControlesDengue / diagnósticoDengue / epidemiologiaVírus da Dengue / imunologiaFemininoHumanosImunoglobulina G / sangueImunoglobulina M / sangueRecém-NascidoMasculinoMicrocefalia / epidemiologiaMicrocefalia / etiologiaGravidezComplicações Infecciosas na Gravidez / diagnósticoComplicações Infecciosas na Gravidez / epidemiologiaAdulto JovemZika virus / imunologiaInfecção por Zika virus / complicaçõesInfecção por Zika virus / diagnósticoInfecção por Zika virus / epidemiologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz 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dc.title.pt_BR.fl_str_mv Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil
title Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil
spellingShingle Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil
Castanha, Priscila M. S.
Zika
Dengue
Microcephaly
Infection
Adolescente
Adulto
Anticorpos Neutralizantes / sangue
Anticorpos Antivirais / sangue
Brasil / epidemiologia
Estudos de Casos e Controles
Dengue / diagnóstico
Dengue / epidemiologia
Vírus da Dengue / imunologia
Feminino
Humanos
Imunoglobulina G / sangue
Imunoglobulina M / sangue
Recém-Nascido
Masculino
Microcefalia / epidemiologia
Microcefalia / etiologia
Gravidez
Complicações Infecciosas na Gravidez / diagnóstico
Complicações Infecciosas na Gravidez / epidemiologia
Adulto Jovem
Zika virus / imunologia
Infecção por Zika virus / complicações
Infecção por Zika virus / diagnóstico
Infecção por Zika virus / epidemiologia
title_short Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil
title_full Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil
title_fullStr Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil
title_full_unstemmed Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil
title_sort Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil
author Castanha, Priscila M. S.
author_facet Castanha, Priscila M. S.
Souza, Wayner V.
Braga, Cynthia
Araújo, Thália Velho Barreto de
Ximenes, Ricardo A. A.
Albuquerque, Maria de Fátima P. M.
Montarroyos, Ulisses R.
Miranda-Filho, Demócrito B.
Cordeiro, Marli T.
Dhalia, Rafael
Marques, Ernesto T. A.
Rodrigues, Laura C.
Martelli, Celina M. T.
author_role author
author2 Souza, Wayner V.
Braga, Cynthia
Araújo, Thália Velho Barreto de
Ximenes, Ricardo A. A.
Albuquerque, Maria de Fátima P. M.
Montarroyos, Ulisses R.
Miranda-Filho, Demócrito B.
Cordeiro, Marli T.
Dhalia, Rafael
Marques, Ernesto T. A.
Rodrigues, Laura C.
Martelli, Celina M. T.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Castanha, Priscila M. S.
Souza, Wayner V.
Braga, Cynthia
Araújo, Thália Velho Barreto de
Ximenes, Ricardo A. A.
Albuquerque, Maria de Fátima P. M.
Montarroyos, Ulisses R.
Miranda-Filho, Demócrito B.
Cordeiro, Marli T.
Dhalia, Rafael
Marques, Ernesto T. A.
Rodrigues, Laura C.
Martelli, Celina M. T.
dc.subject.en.pt_BR.fl_str_mv Zika
Dengue
Microcephaly
Infection
topic Zika
Dengue
Microcephaly
Infection
Adolescente
Adulto
Anticorpos Neutralizantes / sangue
Anticorpos Antivirais / sangue
Brasil / epidemiologia
Estudos de Casos e Controles
Dengue / diagnóstico
Dengue / epidemiologia
Vírus da Dengue / imunologia
Feminino
Humanos
Imunoglobulina G / sangue
Imunoglobulina M / sangue
Recém-Nascido
Masculino
Microcefalia / epidemiologia
Microcefalia / etiologia
Gravidez
Complicações Infecciosas na Gravidez / diagnóstico
Complicações Infecciosas na Gravidez / epidemiologia
Adulto Jovem
Zika virus / imunologia
Infecção por Zika virus / complicações
Infecção por Zika virus / diagnóstico
Infecção por Zika virus / epidemiologia
dc.subject.decs.pt_BR.fl_str_mv Adolescente
Adulto
Anticorpos Neutralizantes / sangue
Anticorpos Antivirais / sangue
Brasil / epidemiologia
Estudos de Casos e Controles
Dengue / diagnóstico
Dengue / epidemiologia
Vírus da Dengue / imunologia
Feminino
Humanos
Imunoglobulina G / sangue
Imunoglobulina M / sangue
Recém-Nascido
Masculino
Microcefalia / epidemiologia
Microcefalia / etiologia
Gravidez
Complicações Infecciosas na Gravidez / diagnóstico
Complicações Infecciosas na Gravidez / epidemiologia
Adulto Jovem
Zika virus / imunologia
Infecção por Zika virus / complicações
Infecção por Zika virus / diagnóstico
Infecção por Zika virus / epidemiologia
description Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Universidade de Pernambuco. Faculdade de Ciências Médicas. Recife, PE, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-10-01T14:52:03Z
dc.date.available.fl_str_mv 2019-10-01T14:52:03Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CASTANHA, Priscila M. S. et al. Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil. PLoS Neglected Tropical Diseases, v. 13, n. 3, p. 1-17, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36040
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0007246
dc.identifier.eissn.pt_BR.fl_str_mv 1935-2735
identifier_str_mv CASTANHA, Priscila M. S. et al. Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil. PLoS Neglected Tropical Diseases, v. 13, n. 3, p. 1-17, 2019.
1935-2727
10.1371/journal.pntd.0007246
1935-2735
url https://www.arca.fiocruz.br/handle/icict/36040
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/36040/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/36040/2/Perinatal%20analyses%20of%20Zika-%20and%20dengue%20virus-specific%20neutralizing%20antibodies.pdf
https://www.arca.fiocruz.br/bitstream/icict/36040/3/Perinatal%20analyses%20of%20Zika-%20and%20dengue%20virus-specific%20neutralizing%20antibodies.pdf.txt
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