Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/49126 |
Resumo: | 1 Department of Biological Chemistry, Universidade Regional do Cariri—URCA, Av. Cel Antônio Luis, 1161, Pimenta, Crato 63105-010, Brazil; priscilla.fernandes@urca.br (P.A.d.S.F.); debora.lima.sales@gmail.com (D.L.S.); martareginakerntopfm@outlook.com (M.R.K.); gyllyandesondelmondes@gmail.com (G.d.A.D.); timotygertor@yahoo.com (G.J.T.S.); lucas-a-b-181@hotmail.com (F.L.A.B.) 2 Department of Biological Sciences, Universidade Regional do Cariri—URCA, Av. Cel Antônio Luis, 1161, Pimenta, Crato 63105-010, Brazil; carol.bio1881@outlook.com (J.C.P.d.S.); flavianamoraib@yahoo.com.br (M.F.B.M.-B.) 3 Embrapa Agroindústria Tropical, Tropical R. Pernambuco, 2270–Pici, Fortaleza 60511-110, Brazil; paulo.riceli@embrapa.br (P.R.V.R.); edy.brito@embrapa.br (E.S.d.B.) 4 Laboratório de Bioensaios, Universidade Federal do Cariri—UFCA, R. Olegário Emídio de Araújo, s/n, Centro, Brejo Santo 63260-000, Brazil; andradejacquelinec@gmail.com 5 Inhamuns Region Education, Science and Technology Center, Universidade Estadual do Ceará—UECE, BR-020—Bezerra de Sousa, Tauá 63660-000, Brazil; fernanimagalhaes@yahoo.com.br 6 Center for the Development of Scientific Research, Asuncion 1255, Paraguay; mcvegagomez@gmail.com (M.C.V.G.); rolonmiriam@gmail.com (M.R.) 7 Laboratório de Investigação em Genética e Hematologia Translacional, Instituto Gonçalo Moniz, FIOCRUZ, Salvador 40296-710, Brazil; cathiacoronel@gmail.com (C.C.); jaimeribeirofilho@gmail.com (J.R.-F.) 8 Department of Botany, Universidade Federal de Pernambuco—UFPE, Av. Prof. Moraes Rego, 1235, Recife 50670-901, Brazil; weverton.almeida@urca.br 9 Ferdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand 9717853577, Iran; asiyadatpanah@yahoo.com 10 School of Allied Health Sciences, World Union for Herbal Drug Discovery (WUHeDD) and Research Excellence Center for Innovation and Health Products (RECIHP), Walailak University, Nakhon Si Thammarat 80160, Thailand; veeranoot.ni@wu.ac.th 11 CICECO-Aveiro Institute of Materials and Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal |
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Fernandes, Priscilla Augusta de SousaSilva, Josefa Carolaine Pereira daSales, Débora LimaRibeiro, Paulo Riceli VasconcelosBrito, Edy Sousa deKerntopf, Marta ReginaDelmondes, Gyllyandeson de AraújoPinheiro, Jacqueline Cosmo AndradeSalazar, Gerson Javier TorresBatista, Francisco Lucas AlvesMagalhães, Francisco Ernani AlvesGomez, Maria Celeste VegaRolón, MíriamCoronel, CathiaRibeiro Filho, JaimeBezerra, José Weverton AlmeidaSiyadatpanah, AbolghasemNissapatorn, VeeranootPereira, Maria de LourdesCoutinho, Henrique Douglas MeloBraga, Maria Flaviana Bezerra Morais2021-09-21T17:47:25Z2021-09-21T17:47:25Z2021FERNANDES, Priscilla Augusta de Sousa et al. Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth. Antibiotics, v. 10, 2021.2079-6382https://www.arca.fiocruz.br/handle/icict/4912610.3390/antibiotics100910741 Department of Biological Chemistry, Universidade Regional do Cariri—URCA, Av. Cel Antônio Luis, 1161, Pimenta, Crato 63105-010, Brazil; priscilla.fernandes@urca.br (P.A.d.S.F.); debora.lima.sales@gmail.com (D.L.S.); martareginakerntopfm@outlook.com (M.R.K.); gyllyandesondelmondes@gmail.com (G.d.A.D.); timotygertor@yahoo.com (G.J.T.S.); lucas-a-b-181@hotmail.com (F.L.A.B.) 2 Department of Biological Sciences, Universidade Regional do Cariri—URCA, Av. Cel Antônio Luis, 1161, Pimenta, Crato 63105-010, Brazil; carol.bio1881@outlook.com (J.C.P.d.S.); flavianamoraib@yahoo.com.br (M.F.B.M.-B.) 3 Embrapa Agroindústria Tropical, Tropical R. Pernambuco, 2270–Pici, Fortaleza 60511-110, Brazil; paulo.riceli@embrapa.br (P.R.V.R.); edy.brito@embrapa.br (E.S.d.B.) 4 Laboratório de Bioensaios, Universidade Federal do Cariri—UFCA, R. Olegário Emídio de Araújo, s/n, Centro, Brejo Santo 63260-000, Brazil; andradejacquelinec@gmail.com 5 Inhamuns Region Education, Science and Technology Center, Universidade Estadual do Ceará—UECE, BR-020—Bezerra de Sousa, Tauá 63660-000, Brazil; fernanimagalhaes@yahoo.com.br 6 Center for the Development of Scientific Research, Asuncion 1255, Paraguay; mcvegagomez@gmail.com (M.C.V.G.); rolonmiriam@gmail.com (M.R.) 7 Laboratório de Investigação em Genética e Hematologia Translacional, Instituto Gonçalo Moniz, FIOCRUZ, Salvador 40296-710, Brazil; cathiacoronel@gmail.com (C.C.); jaimeribeirofilho@gmail.com (J.R.-F.) 8 Department of Botany, Universidade Federal de Pernambuco—UFPE, Av. Prof. Moraes Rego, 1235, Recife 50670-901, Brazil; weverton.almeida@urca.br 9 Ferdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand 9717853577, Iran; asiyadatpanah@yahoo.com 10 School of Allied Health Sciences, World Union for Herbal Drug Discovery (WUHeDD) and Research Excellence Center for Innovation and Health Products (RECIHP), Walailak University, Nakhon Si Thammarat 80160, Thailand; veeranoot.ni@wu.ac.th 11 CICECO-Aveiro Institute of Materials and Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, PortugalFundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico—FUNCAP through a Master’s scholarship.“Múltipla – ver em notas”Croton heliotropiifolius Kunth (Euphorbiaceae), whose occurrence has already been registered in the most varied Brazilian biomes, is commonly found in the Chapada do Araripe, Ceará. The species is traditionally used to treat fungal, parasitic, and degenerative diseases. This study investigated the chemical composition and pharmacological potential (antioxidant, antifungal, antiparasitic, and cytotoxic) of an aqueous extract obtained from the roots of C. heliotropiifolius. Following a qualitative phytochemical screening, the chemical constituents were identified by ultra-efficiency liquid chromatography coupled witha quadrupole/time-of-flight system (UPLC-QTOF). The antioxidant potential was verified by thin-layer chromatography (TLC). The direct and combined antifungal activity of the extract against opportunistic Candida strains was investigated using the microdilution method. The minimal fungicidal concentration (MFC) was determined by subculture, while the modulation of the morphological transition (fungal virulence) was evaluated by light microscopy. The in vitro antiparasitic activity was analyzed using epimastigotes of Trypanosoma cruzi and promastigotes of Leishmania braziliensis and Leishmania infantum, while cytotoxicity was determined in cultures of mouse fibroblasts. The phytochemical analysis identified the presence of acids, terpenes, flavonoids, lignans, and alkaloids. Among these constituents, the presence of polar and non-polar phenolic compounds with known antioxidant action was highlighted. While the extract showed clinically ineffective antifungal effects, it could enhance the effectiveness of fluconazole, in addition to inhibiting the morphological transition associated with increased virulence in Candida strains. Although the extract showed low cytotoxicity against fibroblasts, it also had weak antiparasitic effects. In conclusion, Croton heliotropiifolius is a source of natural products with antifungal and antioxidant potential.engMDPICrotonCompostos fenólicosAntioxidantesCromatografiaAntiparasitáriosCroton heliotropiifoliusPhenolic compoundsAntioxidantAntifungalCytotoxicityChemical Constituents and Biological Activities of Croton heliotropiifolius Kunthinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/49126/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALFernandes, Priscilla Augusto de Sousa Chemical....pdfFernandes, Priscilla Augusto de Sousa Chemical....pdfapplication/pdf1689261https://www.arca.fiocruz.br/bitstream/icict/49126/2/Fernandes%2c%20Priscilla%20Augusto%20de%20Sousa%20Chemical....pdf14d17d813ac22af5c596a97d6533378bMD52icict/491262023-03-15 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dc.title.pt_BR.fl_str_mv |
Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth |
title |
Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth |
spellingShingle |
Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth Fernandes, Priscilla Augusta de Sousa Croton Compostos fenólicos Antioxidantes Cromatografia Antiparasitários Croton heliotropiifolius Phenolic compounds Antioxidant Antifungal Cytotoxicity |
title_short |
Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth |
title_full |
Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth |
title_fullStr |
Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth |
title_full_unstemmed |
Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth |
title_sort |
Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth |
author |
Fernandes, Priscilla Augusta de Sousa |
author_facet |
Fernandes, Priscilla Augusta de Sousa Silva, Josefa Carolaine Pereira da Sales, Débora Lima Ribeiro, Paulo Riceli Vasconcelos Brito, Edy Sousa de Kerntopf, Marta Regina Delmondes, Gyllyandeson de Araújo Pinheiro, Jacqueline Cosmo Andrade Salazar, Gerson Javier Torres Batista, Francisco Lucas Alves Magalhães, Francisco Ernani Alves Gomez, Maria Celeste Vega Rolón, Míriam Coronel, Cathia Ribeiro Filho, Jaime Bezerra, José Weverton Almeida Siyadatpanah, Abolghasem Nissapatorn, Veeranoot Pereira, Maria de Lourdes Coutinho, Henrique Douglas Melo Braga, Maria Flaviana Bezerra Morais |
author_role |
author |
author2 |
Silva, Josefa Carolaine Pereira da Sales, Débora Lima Ribeiro, Paulo Riceli Vasconcelos Brito, Edy Sousa de Kerntopf, Marta Regina Delmondes, Gyllyandeson de Araújo Pinheiro, Jacqueline Cosmo Andrade Salazar, Gerson Javier Torres Batista, Francisco Lucas Alves Magalhães, Francisco Ernani Alves Gomez, Maria Celeste Vega Rolón, Míriam Coronel, Cathia Ribeiro Filho, Jaime Bezerra, José Weverton Almeida Siyadatpanah, Abolghasem Nissapatorn, Veeranoot Pereira, Maria de Lourdes Coutinho, Henrique Douglas Melo Braga, Maria Flaviana Bezerra Morais |
author2_role |
author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Fernandes, Priscilla Augusta de Sousa Silva, Josefa Carolaine Pereira da Sales, Débora Lima Ribeiro, Paulo Riceli Vasconcelos Brito, Edy Sousa de Kerntopf, Marta Regina Delmondes, Gyllyandeson de Araújo Pinheiro, Jacqueline Cosmo Andrade Salazar, Gerson Javier Torres Batista, Francisco Lucas Alves Magalhães, Francisco Ernani Alves Gomez, Maria Celeste Vega Rolón, Míriam Coronel, Cathia Ribeiro Filho, Jaime Bezerra, José Weverton Almeida Siyadatpanah, Abolghasem Nissapatorn, Veeranoot Pereira, Maria de Lourdes Coutinho, Henrique Douglas Melo Braga, Maria Flaviana Bezerra Morais |
dc.subject.other.pt_BR.fl_str_mv |
Croton Compostos fenólicos Antioxidantes Cromatografia Antiparasitários |
topic |
Croton Compostos fenólicos Antioxidantes Cromatografia Antiparasitários Croton heliotropiifolius Phenolic compounds Antioxidant Antifungal Cytotoxicity |
dc.subject.en.pt_BR.fl_str_mv |
Croton heliotropiifolius Phenolic compounds Antioxidant Antifungal Cytotoxicity |
description |
1 Department of Biological Chemistry, Universidade Regional do Cariri—URCA, Av. Cel Antônio Luis, 1161, Pimenta, Crato 63105-010, Brazil; priscilla.fernandes@urca.br (P.A.d.S.F.); debora.lima.sales@gmail.com (D.L.S.); martareginakerntopfm@outlook.com (M.R.K.); gyllyandesondelmondes@gmail.com (G.d.A.D.); timotygertor@yahoo.com (G.J.T.S.); lucas-a-b-181@hotmail.com (F.L.A.B.) 2 Department of Biological Sciences, Universidade Regional do Cariri—URCA, Av. Cel Antônio Luis, 1161, Pimenta, Crato 63105-010, Brazil; carol.bio1881@outlook.com (J.C.P.d.S.); flavianamoraib@yahoo.com.br (M.F.B.M.-B.) 3 Embrapa Agroindústria Tropical, Tropical R. Pernambuco, 2270–Pici, Fortaleza 60511-110, Brazil; paulo.riceli@embrapa.br (P.R.V.R.); edy.brito@embrapa.br (E.S.d.B.) 4 Laboratório de Bioensaios, Universidade Federal do Cariri—UFCA, R. Olegário Emídio de Araújo, s/n, Centro, Brejo Santo 63260-000, Brazil; andradejacquelinec@gmail.com 5 Inhamuns Region Education, Science and Technology Center, Universidade Estadual do Ceará—UECE, BR-020—Bezerra de Sousa, Tauá 63660-000, Brazil; fernanimagalhaes@yahoo.com.br 6 Center for the Development of Scientific Research, Asuncion 1255, Paraguay; mcvegagomez@gmail.com (M.C.V.G.); rolonmiriam@gmail.com (M.R.) 7 Laboratório de Investigação em Genética e Hematologia Translacional, Instituto Gonçalo Moniz, FIOCRUZ, Salvador 40296-710, Brazil; cathiacoronel@gmail.com (C.C.); jaimeribeirofilho@gmail.com (J.R.-F.) 8 Department of Botany, Universidade Federal de Pernambuco—UFPE, Av. Prof. Moraes Rego, 1235, Recife 50670-901, Brazil; weverton.almeida@urca.br 9 Ferdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand 9717853577, Iran; asiyadatpanah@yahoo.com 10 School of Allied Health Sciences, World Union for Herbal Drug Discovery (WUHeDD) and Research Excellence Center for Innovation and Health Products (RECIHP), Walailak University, Nakhon Si Thammarat 80160, Thailand; veeranoot.ni@wu.ac.th 11 CICECO-Aveiro Institute of Materials and Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-09-21T17:47:25Z |
dc.date.available.fl_str_mv |
2021-09-21T17:47:25Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FERNANDES, Priscilla Augusta de Sousa et al. Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth. Antibiotics, v. 10, 2021. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/49126 |
dc.identifier.issn.pt_BR.fl_str_mv |
2079-6382 |
dc.identifier.doi.none.fl_str_mv |
10.3390/antibiotics10091074 |
identifier_str_mv |
FERNANDES, Priscilla Augusta de Sousa et al. Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth. Antibiotics, v. 10, 2021. 2079-6382 10.3390/antibiotics10091074 |
url |
https://www.arca.fiocruz.br/handle/icict/49126 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
collection |
Repositório Institucional da FIOCRUZ (ARCA) |
bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/49126/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/49126/2/Fernandes%2c%20Priscilla%20Augusto%20de%20Sousa%20Chemical....pdf |
bitstream.checksum.fl_str_mv |
36b51ef91c52b5338d9d29ba0cc807bc 14d17d813ac22af5c596a97d6533378b |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
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1813009000041545728 |