Transplanted bone marrow cells repair heart tissue and reduce myocarditis in chronic chagasic mice.

Detalhes bibliográficos
Autor(a) principal: Soares, Milena Botelho Pereira
Data de Publicação: 2004
Outros Autores: Lima, Ricardo Santana de, Rocha, Leonardo Lima, Takiya, Christina Maeda, Pontes-de-Carvalho, Lain Carlos, Carvalho, Antonio Carlos Campos de, Santos, Ricardo Ribeiro dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5741
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
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spelling Soares, Milena Botelho PereiraLima, Ricardo Santana deRocha, Leonardo LimaTakiya, Christina MaedaPontes-de-Carvalho, Lain CarlosCarvalho, Antonio Carlos Campos deSantos, Ricardo Ribeiro dos2012-10-26T20:55:49Z2012-10-26T20:55:49Z2004SOARES, M. B. et al. Transplanted bone marrow cells repair heart tissue and reduce myocarditis in chronic chagasic mice. American Journal of Pathology, v. 164, n. 2, p. 441-447, Feb. 2004.0002-9440https://www.arca.fiocruz.br/handle/icict/5741engTransplanted bone marrow cells repair heart tissue and reduce myocarditis in chronic chagasic mice.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal do Rio de Janeiro. Institutos de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal do Rio de Janeiro. Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.A progressive destruction of the myocardium occurs in approximately 30% of Trypanosoma cruzi-infected individuals, causing chronic chagasic cardiomyopathy, a disease so far without effective treatment. Syngeneic bone marrow cell transplantation has been shown to cause repair and improvement of heart function in a number of studies in patients and animal models of ischemic cardiopathy. The effects of bone marrow transplant in a mouse model of chronic chagasic cardiomyopathy, in the presence of the disease causal agent, ie, the T. cruzi, are described herein. Bone marrow cells injected intravenously into chronic chagasic mice migrated to the heart and caused a significant reduction in the inflammatory infiltrates and in the interstitial fibrosis characteristics of chronic chagasic cardiomyopathy. The beneficial effects were observed up to 6 months after bone marrow cell transplantation. A massive apoptosis of myocardial inflammatory cells was observed after the therapy with bone marrow cells. Transplanted bone marrow cells obtained from chagasic mice and from normal mice had similar effects in terms of mediating chagasic heart repair. These results show that bone marrow cell transplantation is effective for treatment of chronic chagasic myocarditis and indicate that autologous bone marrow transplant may be used as an efficient therapy for patients with chronic chagasic cardiomyopathy.Transplante de Medula ÓsseaCardiomiopatia Chagásica/cirurgiaMiocárdio/patologiaAnimaisApoptose/fisiologiaMovimento CelularCardiomiopatia Chagásica/etiologiaDoença CrônicaModelos Animais de DoençasFemininoFibrose/patologiaMarcação In Situ das Extremidades CortadasMasculinoTrypanosoma cruziinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSoares MB Transplanted bone marrow....pdfSoares MB Transplanted bone marrow....pdfapplication/pdf596694https://www.arca.fiocruz.br/bitstream/icict/5741/1/Soares%20MB%20Transplanted%20bone%20marrow....pdfb010da0d53e45b5ade8c49a85df02019MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5741/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTSoares MB Transplanted bone marrow....pdf.txtSoares MB Transplanted bone marrow....pdf.txtExtracted texttext/plain34551https://www.arca.fiocruz.br/bitstream/icict/5741/5/Soares%20MB%20Transplanted%20bone%20marrow....pdf.txt79eb87e96b13e9e84e1d71ff71ac64deMD55THUMBNAILSoares MB Transplanted bone marrow....pdf.jpgSoares MB Transplanted bone marrow....pdf.jpgGenerated Thumbnailimage/jpeg2250https://www.arca.fiocruz.br/bitstream/icict/5741/4/Soares%20MB%20Transplanted%20bone%20marrow....pdf.jpg54e6c7d7e5479ae4cb9e48297b378762MD54icict/57412023-03-15 14:33:55.175oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:55Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Transplanted bone marrow cells repair heart tissue and reduce myocarditis in chronic chagasic mice.
title Transplanted bone marrow cells repair heart tissue and reduce myocarditis in chronic chagasic mice.
spellingShingle Transplanted bone marrow cells repair heart tissue and reduce myocarditis in chronic chagasic mice.
Soares, Milena Botelho Pereira
Transplante de Medula Óssea
Cardiomiopatia Chagásica/cirurgia
Miocárdio/patologia
Animais
Apoptose/fisiologia
Movimento Celular
Cardiomiopatia Chagásica/etiologia
Doença Crônica
Modelos Animais de Doenças
Feminino
Fibrose/patologia
Marcação In Situ das Extremidades Cortadas
Masculino
Trypanosoma cruzi
title_short Transplanted bone marrow cells repair heart tissue and reduce myocarditis in chronic chagasic mice.
title_full Transplanted bone marrow cells repair heart tissue and reduce myocarditis in chronic chagasic mice.
title_fullStr Transplanted bone marrow cells repair heart tissue and reduce myocarditis in chronic chagasic mice.
title_full_unstemmed Transplanted bone marrow cells repair heart tissue and reduce myocarditis in chronic chagasic mice.
title_sort Transplanted bone marrow cells repair heart tissue and reduce myocarditis in chronic chagasic mice.
author Soares, Milena Botelho Pereira
author_facet Soares, Milena Botelho Pereira
Lima, Ricardo Santana de
Rocha, Leonardo Lima
Takiya, Christina Maeda
Pontes-de-Carvalho, Lain Carlos
Carvalho, Antonio Carlos Campos de
Santos, Ricardo Ribeiro dos
author_role author
author2 Lima, Ricardo Santana de
Rocha, Leonardo Lima
Takiya, Christina Maeda
Pontes-de-Carvalho, Lain Carlos
Carvalho, Antonio Carlos Campos de
Santos, Ricardo Ribeiro dos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Soares, Milena Botelho Pereira
Lima, Ricardo Santana de
Rocha, Leonardo Lima
Takiya, Christina Maeda
Pontes-de-Carvalho, Lain Carlos
Carvalho, Antonio Carlos Campos de
Santos, Ricardo Ribeiro dos
dc.subject.decs.pt_BR.fl_str_mv Transplante de Medula Óssea
Cardiomiopatia Chagásica/cirurgia
Miocárdio/patologia
Animais
Apoptose/fisiologia
Movimento Celular
Cardiomiopatia Chagásica/etiologia
Doença Crônica
Modelos Animais de Doenças
Feminino
Fibrose/patologia
Marcação In Situ das Extremidades Cortadas
Masculino
Trypanosoma cruzi
topic Transplante de Medula Óssea
Cardiomiopatia Chagásica/cirurgia
Miocárdio/patologia
Animais
Apoptose/fisiologia
Movimento Celular
Cardiomiopatia Chagásica/etiologia
Doença Crônica
Modelos Animais de Doenças
Feminino
Fibrose/patologia
Marcação In Situ das Extremidades Cortadas
Masculino
Trypanosoma cruzi
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2012-10-26T20:55:49Z
dc.date.available.fl_str_mv 2012-10-26T20:55:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SOARES, M. B. et al. Transplanted bone marrow cells repair heart tissue and reduce myocarditis in chronic chagasic mice. American Journal of Pathology, v. 164, n. 2, p. 441-447, Feb. 2004.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5741
dc.identifier.issn.none.fl_str_mv 0002-9440
identifier_str_mv SOARES, M. B. et al. Transplanted bone marrow cells repair heart tissue and reduce myocarditis in chronic chagasic mice. American Journal of Pathology, v. 164, n. 2, p. 441-447, Feb. 2004.
0002-9440
url https://www.arca.fiocruz.br/handle/icict/5741
dc.language.iso.fl_str_mv eng
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