Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent

Detalhes bibliográficos
Autor(a) principal: Felzemburgh, Ridalva Dias Martins
Data de Publicação: 2014
Outros Autores: Ribeiro, Guilherme de Sousa, Costa, Federico, Renato B. Reis, Hagan, José Edward, Melendez, Astrid X. T. O, Deborah Fraga, Francisco S. Santana, Sharif Mohr, Santos, Balbino L. dos, Silva, Adriano Queiroz, Andréia C. Santos, Ravines, Romy R, Tassinari, Wagner S, Carvalho, Marilia Sá, Reis, Mitermayer Galvão dos, Ko, Albert Icksang
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7799
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Enfermagem. Salvador, BA, Brasil
id CRUZ_4fe84d20f0a3182198bdfff419f94079
oai_identifier_str oai:www.arca.fiocruz.br:icict/7799
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Felzemburgh, Ridalva Dias MartinsRibeiro, Guilherme de SousaCosta, FedericoRenato B. ReisHagan, José EdwardMelendez, Astrid X. T. ODeborah FragaFrancisco S. SantanaSharif MohrSantos, Balbino L. dosSilva, Adriano QueirozAndréia C. SantosRavines, Romy RTassinari, Wagner SCarvalho, Marilia SáReis, Mitermayer Galvão dosKo, Albert Icksang2014-06-05T14:04:26Z2014-06-05T14:04:26Z2014FELZEMBURGH, R. D. et al. Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent. PLoS Neglected Tropical Diseases,v. 8, n. 5, p. e2927, 2014.1935-272710.1371/journal.pntd.0002927https://www.arca.fiocruz.br/handle/icict/7799engPublic Library of ScienceLeptospiroseLeptospiraFavelasSaúde urbanaFatores de riscoMasculinoInfecçãoProspective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agentinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Enfermagem. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Yale University. Department of Epidemiology of Microbial Diseases. School of Public Health. New Haven, Connecticut, USAFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Yale University. Department of Epidemiology of Microbial Diseases. School of Public Health. New Haven, Connecticut, USAFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Secretaria Estadual de Saúde da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Escola Nacional da Saúde Pública. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Escola Nacional da Saúde Pública. Rio de Janeiro, RJ, Brasil / Universidade Federal Rural do Rio de Janeiro. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Escola Nacional da Saúde Pública. Rio de Janeiro, RJ, BrasilBackground: Leptospirosis has emerged as an urban health problem as slum settlements have rapidly spread worldwide and created conditions for rat-borne transmission. Prospective studies have not been performed to determine the disease burden, identify risk factors for infection and provide information needed to guide interventions in these marginalized communities. Methodology/Principal Findings: We enrolled and followed a cohort of 2,003 residents from a slum community in the city of Salvador, Brazil. Baseline and one-year serosurveys were performed to identify primary and secondary Leptospira infections, defined as respectively, seroconversion and four-fold rise in microscopic agglutination titers. We used multinomial logistic regression models to evaluate risk exposures for acquiring primary and secondary infection. A total of 51 Leptospira infections were identified among 1,585 (79%) participants who completed the one-year follow-up protocol. The crude infection rate was 37.8 per 1,000 person-years. The secondary infection rate was 2.3 times higher than that of primary infection rate (71.7 and 31.1 infections per 1,000 person-years, respectively). Male gender (OR 2.88; 95% CI 1.40– 5.91) and lower per capita household income (OR 0.54; 95% CI, 0.30–0.98 for an increase of $1 per person per day) were independent risk factors for primary infection. In contrast, the 15–34 year age group (OR 10.82, 95% CI 1.38–85.08), and proximity of residence to an open sewer (OR 0.95; 0.91–0.99 for an increase of 1 m distance) were significant risk factors for secondary infection. Conclusions/Significance: This study found that slum residents had high risk (.3% per year) for acquiring a Leptospira infection. Re-infection is a frequent event and occurs in regions of slum settlements that are in proximity to open sewers. Effective prevention of leptospirosis will therefore require interventions that address the infrastructure deficiencies that contribute to repeated exposures among slum inhabitants.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALFelzemburgh RD Prospective study....pdfFelzemburgh RD Prospective study....pdfapplication/pdf263082https://www.arca.fiocruz.br/bitstream/icict/7799/1/Felzemburgh%20RD%20Prospective%20study....pdf2b20d1b45b8944b9d4ef7d31159c3c96MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7799/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTFelzemburgh RD Prospective study....pdf.txtFelzemburgh RD Prospective study....pdf.txtExtracted texttext/plain57616https://www.arca.fiocruz.br/bitstream/icict/7799/5/Felzemburgh%20RD%20Prospective%20study....pdf.txt4295bbcb12dde1c95c3e3c31ad08746fMD55THUMBNAILFelzemburgh RD Prospective study....pdf.jpgFelzemburgh RD Prospective study....pdf.jpgGenerated Thumbnailimage/jpeg2739https://www.arca.fiocruz.br/bitstream/icict/7799/4/Felzemburgh%20RD%20Prospective%20study....pdf.jpg69cf1c3ca766a38b5af679bdb946066fMD54icict/77992023-03-15 14:33:21.183oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent
title Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent
spellingShingle Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent
Felzemburgh, Ridalva Dias Martins
Leptospirose
Leptospira
Favelas
Saúde urbana
Fatores de risco
Masculino
Infecção
title_short Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent
title_full Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent
title_fullStr Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent
title_full_unstemmed Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent
title_sort Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent
author Felzemburgh, Ridalva Dias Martins
author_facet Felzemburgh, Ridalva Dias Martins
Ribeiro, Guilherme de Sousa
Costa, Federico
Renato B. Reis
Hagan, José Edward
Melendez, Astrid X. T. O
Deborah Fraga
Francisco S. Santana
Sharif Mohr
Santos, Balbino L. dos
Silva, Adriano Queiroz
Andréia C. Santos
Ravines, Romy R
Tassinari, Wagner S
Carvalho, Marilia Sá
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
author_role author
author2 Ribeiro, Guilherme de Sousa
Costa, Federico
Renato B. Reis
Hagan, José Edward
Melendez, Astrid X. T. O
Deborah Fraga
Francisco S. Santana
Sharif Mohr
Santos, Balbino L. dos
Silva, Adriano Queiroz
Andréia C. Santos
Ravines, Romy R
Tassinari, Wagner S
Carvalho, Marilia Sá
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Felzemburgh, Ridalva Dias Martins
Ribeiro, Guilherme de Sousa
Costa, Federico
Renato B. Reis
Hagan, José Edward
Melendez, Astrid X. T. O
Deborah Fraga
Francisco S. Santana
Sharif Mohr
Santos, Balbino L. dos
Silva, Adriano Queiroz
Andréia C. Santos
Ravines, Romy R
Tassinari, Wagner S
Carvalho, Marilia Sá
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
dc.subject.other.pt_BR.fl_str_mv Leptospirose
Leptospira
Favelas
Saúde urbana
Fatores de risco
Masculino
Infecção
topic Leptospirose
Leptospira
Favelas
Saúde urbana
Fatores de risco
Masculino
Infecção
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Enfermagem. Salvador, BA, Brasil
publishDate 2014
dc.date.accessioned.fl_str_mv 2014-06-05T14:04:26Z
dc.date.available.fl_str_mv 2014-06-05T14:04:26Z
dc.date.issued.fl_str_mv 2014
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FELZEMBURGH, R. D. et al. Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent. PLoS Neglected Tropical Diseases,v. 8, n. 5, p. e2927, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7799
dc.identifier.issn.none.fl_str_mv 1935-2727
10.1371/journal.pntd.0002927
identifier_str_mv FELZEMBURGH, R. D. et al. Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent. PLoS Neglected Tropical Diseases,v. 8, n. 5, p. e2927, 2014.
1935-2727
10.1371/journal.pntd.0002927
url https://www.arca.fiocruz.br/handle/icict/7799
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/7799/1/Felzemburgh%20RD%20Prospective%20study....pdf
https://www.arca.fiocruz.br/bitstream/icict/7799/2/license.txt
https://www.arca.fiocruz.br/bitstream/icict/7799/5/Felzemburgh%20RD%20Prospective%20study....pdf.txt
https://www.arca.fiocruz.br/bitstream/icict/7799/4/Felzemburgh%20RD%20Prospective%20study....pdf.jpg
bitstream.checksum.fl_str_mv 2b20d1b45b8944b9d4ef7d31159c3c96
7d48279ffeed55da8dfe2f8e81f3b81f
4295bbcb12dde1c95c3e3c31ad08746f
69cf1c3ca766a38b5af679bdb946066f
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009006076100608