Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae)
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20720 |
Resumo: | Bezerra, Daniel Pereira “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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Fontes, José Eraldo do NascimentoFerraz, Rosana Paula CruzBritto, Anny Caroline SiqueiraCarvalho, Adriana AndradeMoraes, Manoel OPessoa, Claudia do ÓCosta, Emmanoel VilaçaBezerra, Daniel Pereira2017-08-23T18:14:51Z2017-08-23T18:14:51Z2013FONTES, J. E. N. et al. Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae). Chemistry and Biodiversity, v. 10, p. 722-729, 2013.1612-1872https://www.arca.fiocruz.br/handle/icict/2072010.1002/cbdv.201200304Bezerra, Daniel Pereira “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.(Coordenadoria de Apoio a Pesquisa e Ensino Superior), CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnológico), FUNCAP (Fundação Cearense de Apoio ao Desenvolvimento Cientí fico e Tecnológico), and FAPITEC/SE (Fundação de Amparo à Pesquisa e à Inovação Tecnológica do Estado de Sergipe).Federal University of Sergipe. Department of Chemistry. São Cristóvão. Aracaju, SE, BrazilFederal University of Sergipe. Department of Physiology. São Cristóvão. Aracaju, SE, BrazilFederal University of Sergipe. Department of Physiology. São Cristóvão. Aracaju, SE, BrazilFederal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, BrazilFederal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, BrazilFederal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, BrazilFederal University of Sergipe. Department of Chemistry. São Cristóvão. Aracaju, SE, BrazilFederal University of Sergipe. Department of Physiology. São Cristóvão. Aracaju, SE, BrazilGuatteria pogonopus Martius, a plant belonging to the Annonaceae family, is found in the remaining Brazilian Atlantic Forest. In this study, the chemical composition and antitumor effects of the essential oil isolated from leaves of G. pogonopus was investigated. The chemical composition of the oil was determined by GC-FID and GC/MS analyses. The in vitro cytotoxicity was evaluated against three different tumor cell lines (OVCAR-8, NCI-H358M, and PC-3M), and the in vivo antitumor activity was tested in mice bearing sarcoma 180 tumor. A total of 29 compounds was identified and quantified in the oil. The major compounds were γ-patchoulene (13.55%), (E)-caryophyllene (11.36%), β-pinene (10.37%), germacrene D (6.72%), bicyclogermacrene (5.97%), α-pinene (5.33%), and germacrene B (4.69%). The essential oil, but neither (E)-caryophyllene nor β-pinene, displayed in vitro cytotoxicity against all three tumor cell lines tested. The obtained average IC50 values ranged from 3.8 to 20.8 μg/ml. The lowest and highest values were obtained against the NCI-H358M and the OVCAR-8 cell lines, respectively. The in vivo tumor-growth-inhibition rates in the tumor-bearing mice treated with essential oil (50 and 100 mg/kg/d) were 25.3 and 42.6%, respectively. Hence, the essential oil showed significant in vitro and in vivo antitumor activity.engWileySarcomaTumorNeoplasiasTransplanteFolhas de plantasÓleosRatosSarcomaCell Line, TumorNeoplasmsTransplantation, HeterologousPlant LeavesOils, VolatileMiceAntitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20720/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFontes, JE Antitumor effect of the essencial....pdfFontes, JE Antitumor effect of the essencial....pdfapplication/pdf193925https://www.arca.fiocruz.br/bitstream/icict/20720/2/Fontes%2c%20JE%20Antitumor%20effect%20%20of%20the%20essencial....pdfc85bde7025916debb314f2f3ce339aaaMD52TEXTFontes, JE 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| dc.title.pt_BR.fl_str_mv |
Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae) |
| title |
Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae) |
| spellingShingle |
Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae) Fontes, José Eraldo do Nascimento Sarcoma Tumor Neoplasias Transplante Folhas de plantas Óleos Ratos Sarcoma Cell Line, Tumor Neoplasms Transplantation, Heterologous Plant Leaves Oils, Volatile Mice |
| title_short |
Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae) |
| title_full |
Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae) |
| title_fullStr |
Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae) |
| title_full_unstemmed |
Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae) |
| title_sort |
Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae) |
| author |
Fontes, José Eraldo do Nascimento |
| author_facet |
Fontes, José Eraldo do Nascimento Ferraz, Rosana Paula Cruz Britto, Anny Caroline Siqueira Carvalho, Adriana Andrade Moraes, Manoel O Pessoa, Claudia do Ó Costa, Emmanoel Vilaça Bezerra, Daniel Pereira |
| author_role |
author |
| author2 |
Ferraz, Rosana Paula Cruz Britto, Anny Caroline Siqueira Carvalho, Adriana Andrade Moraes, Manoel O Pessoa, Claudia do Ó Costa, Emmanoel Vilaça Bezerra, Daniel Pereira |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Fontes, José Eraldo do Nascimento Ferraz, Rosana Paula Cruz Britto, Anny Caroline Siqueira Carvalho, Adriana Andrade Moraes, Manoel O Pessoa, Claudia do Ó Costa, Emmanoel Vilaça Bezerra, Daniel Pereira |
| dc.subject.other.pt_BR.fl_str_mv |
Sarcoma Tumor Neoplasias Transplante Folhas de plantas Óleos Ratos |
| topic |
Sarcoma Tumor Neoplasias Transplante Folhas de plantas Óleos Ratos Sarcoma Cell Line, Tumor Neoplasms Transplantation, Heterologous Plant Leaves Oils, Volatile Mice |
| dc.subject.en.pt_BR.fl_str_mv |
Sarcoma Cell Line, Tumor Neoplasms Transplantation, Heterologous Plant Leaves Oils, Volatile Mice |
| description |
Bezerra, Daniel Pereira “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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2013 |
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2013 |
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2017-08-23T18:14:51Z |
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2017-08-23T18:14:51Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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FONTES, J. E. N. et al. Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae). Chemistry and Biodiversity, v. 10, p. 722-729, 2013. |
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https://www.arca.fiocruz.br/handle/icict/20720 |
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1612-1872 |
| dc.identifier.doi.none.fl_str_mv |
10.1002/cbdv.201200304 |
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FONTES, J. E. N. et al. Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae). Chemistry and Biodiversity, v. 10, p. 722-729, 2013. 1612-1872 10.1002/cbdv.201200304 |
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Wiley |
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