Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae)
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/5437 |
Resumo: | Guatteria pogonopus Martius , a plant belonging to the Annonaceae family, is found in the remaining Brazilian Atlantic Forest. In this study, the chemical composition and antitumor effects of the essential oil isolated from leaves of G. pogonopus was investigated. The chemical composition of the oil was determined by GC-FID and GC/MS analyses. The in vitro cytotoxicity was evaluated against three different tumor cell lines (OVCAR-8, NCI-H358M, and PC-3M), and the in vivo antitumor activity was tested in mice bearing sarcoma 180 tumor. A total of 29 compounds was identified and quantified in the oil. The major compounds were g -patchoulene (13.55%), ( E )-caryophyllene (11.36%), b -pinene (10.37%), germacrene D (6.72%), bicyclogermacrene (5.97%), a -pinene (5.33%), and germacrene B (4.69%). The essential oil, but neither ( E )-caryophyllene nor b -pinene, displayed in vitro cytotoxicity against all three tumor cell lines tested. The obtained average IC 50 values ranged from 3.8 to 20.8 m g/ml. The lowest and highest values were obtained against the NCI-H358M and the OVCAR-8 cell lines, respectively. The in vivo tumor-growth-inhibition rates in the tumor-bearing mice treated with essential oil (50 and 100 mg/kg/d) were 25.3 and 42.6%, respectively. Hence, the essential oil showed significant in vitro and in vivo antitumor activity. |
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Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae)Óleos VoláteisGuatteriaGuatteria pogonopus Martius , a plant belonging to the Annonaceae family, is found in the remaining Brazilian Atlantic Forest. In this study, the chemical composition and antitumor effects of the essential oil isolated from leaves of G. pogonopus was investigated. The chemical composition of the oil was determined by GC-FID and GC/MS analyses. The in vitro cytotoxicity was evaluated against three different tumor cell lines (OVCAR-8, NCI-H358M, and PC-3M), and the in vivo antitumor activity was tested in mice bearing sarcoma 180 tumor. A total of 29 compounds was identified and quantified in the oil. The major compounds were g -patchoulene (13.55%), ( E )-caryophyllene (11.36%), b -pinene (10.37%), germacrene D (6.72%), bicyclogermacrene (5.97%), a -pinene (5.33%), and germacrene B (4.69%). The essential oil, but neither ( E )-caryophyllene nor b -pinene, displayed in vitro cytotoxicity against all three tumor cell lines tested. The obtained average IC 50 values ranged from 3.8 to 20.8 m g/ml. The lowest and highest values were obtained against the NCI-H358M and the OVCAR-8 cell lines, respectively. The in vivo tumor-growth-inhibition rates in the tumor-bearing mice treated with essential oil (50 and 100 mg/kg/d) were 25.3 and 42.6%, respectively. Hence, the essential oil showed significant in vitro and in vivo antitumor activity.Chemistry & Biodiversity2013-07-18T15:27:42Z2013-07-18T15:27:42Z2013-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfFONTES, J. E. N. et al. Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae. Chemistry & Biodiversity, v. 10, n. 4, p. 722-729, abr. 2013.1612-1872 Impressa1612-1880 On linehttp://www.repositorio.ufc.br/handle/riufc/5437Fontes, José Eraldo do N.Ferraz, Rosana P. C.Britto, Anny C. S.Carvalho, Adriana A.Moraes Filho, Manoel Odorico dePessoa, ClaudiaCosta, Emmanoel V.Bezerra, Daniel P.engreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-11-10T23:07:01Zoai:repositorio.ufc.br:riufc/5437Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:51:21.779137Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae) |
title |
Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae) |
spellingShingle |
Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae) Fontes, José Eraldo do N. Óleos Voláteis Guatteria |
title_short |
Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae) |
title_full |
Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae) |
title_fullStr |
Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae) |
title_full_unstemmed |
Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae) |
title_sort |
Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae) |
author |
Fontes, José Eraldo do N. |
author_facet |
Fontes, José Eraldo do N. Ferraz, Rosana P. C. Britto, Anny C. S. Carvalho, Adriana A. Moraes Filho, Manoel Odorico de Pessoa, Claudia Costa, Emmanoel V. Bezerra, Daniel P. |
author_role |
author |
author2 |
Ferraz, Rosana P. C. Britto, Anny C. S. Carvalho, Adriana A. Moraes Filho, Manoel Odorico de Pessoa, Claudia Costa, Emmanoel V. Bezerra, Daniel P. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Fontes, José Eraldo do N. Ferraz, Rosana P. C. Britto, Anny C. S. Carvalho, Adriana A. Moraes Filho, Manoel Odorico de Pessoa, Claudia Costa, Emmanoel V. Bezerra, Daniel P. |
dc.subject.por.fl_str_mv |
Óleos Voláteis Guatteria |
topic |
Óleos Voláteis Guatteria |
description |
Guatteria pogonopus Martius , a plant belonging to the Annonaceae family, is found in the remaining Brazilian Atlantic Forest. In this study, the chemical composition and antitumor effects of the essential oil isolated from leaves of G. pogonopus was investigated. The chemical composition of the oil was determined by GC-FID and GC/MS analyses. The in vitro cytotoxicity was evaluated against three different tumor cell lines (OVCAR-8, NCI-H358M, and PC-3M), and the in vivo antitumor activity was tested in mice bearing sarcoma 180 tumor. A total of 29 compounds was identified and quantified in the oil. The major compounds were g -patchoulene (13.55%), ( E )-caryophyllene (11.36%), b -pinene (10.37%), germacrene D (6.72%), bicyclogermacrene (5.97%), a -pinene (5.33%), and germacrene B (4.69%). The essential oil, but neither ( E )-caryophyllene nor b -pinene, displayed in vitro cytotoxicity against all three tumor cell lines tested. The obtained average IC 50 values ranged from 3.8 to 20.8 m g/ml. The lowest and highest values were obtained against the NCI-H358M and the OVCAR-8 cell lines, respectively. The in vivo tumor-growth-inhibition rates in the tumor-bearing mice treated with essential oil (50 and 100 mg/kg/d) were 25.3 and 42.6%, respectively. Hence, the essential oil showed significant in vitro and in vivo antitumor activity. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-07-18T15:27:42Z 2013-07-18T15:27:42Z 2013-04 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
FONTES, J. E. N. et al. Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae. Chemistry & Biodiversity, v. 10, n. 4, p. 722-729, abr. 2013. 1612-1872 Impressa 1612-1880 On line http://www.repositorio.ufc.br/handle/riufc/5437 |
identifier_str_mv |
FONTES, J. E. N. et al. Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae. Chemistry & Biodiversity, v. 10, n. 4, p. 722-729, abr. 2013. 1612-1872 Impressa 1612-1880 On line |
url |
http://www.repositorio.ufc.br/handle/riufc/5437 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Chemistry & Biodiversity |
publisher.none.fl_str_mv |
Chemistry & Biodiversity |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
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1813028972475187200 |