Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae)

Detalhes bibliográficos
Autor(a) principal: Fontes, José Eraldo do N.
Data de Publicação: 2013
Outros Autores: Ferraz, Rosana P. C., Britto, Anny C. S., Carvalho, Adriana A., Moraes Filho, Manoel Odorico de, Pessoa, Claudia, Costa, Emmanoel V., Bezerra, Daniel P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/5437
Resumo: Guatteria pogonopus Martius , a plant belonging to the Annonaceae family, is found in the remaining Brazilian Atlantic Forest. In this study, the chemical composition and antitumor effects of the essential oil isolated from leaves of G. pogonopus was investigated. The chemical composition of the oil was determined by GC-FID and GC/MS analyses. The in vitro cytotoxicity was evaluated against three different tumor cell lines (OVCAR-8, NCI-H358M, and PC-3M), and the in vivo antitumor activity was tested in mice bearing sarcoma 180 tumor. A total of 29 compounds was identified and quantified in the oil. The major compounds were g -patchoulene (13.55%), ( E )-caryophyllene (11.36%), b -pinene (10.37%), germacrene D (6.72%), bicyclogermacrene (5.97%), a -pinene (5.33%), and germacrene B (4.69%). The essential oil, but neither ( E )-caryophyllene nor b -pinene, displayed in vitro cytotoxicity against all three tumor cell lines tested. The obtained average IC 50 values ranged from 3.8 to 20.8 m g/ml. The lowest and highest values were obtained against the NCI-H358M and the OVCAR-8 cell lines, respectively. The in vivo tumor-growth-inhibition rates in the tumor-bearing mice treated with essential oil (50 and 100 mg/kg/d) were 25.3 and 42.6%, respectively. Hence, the essential oil showed significant in vitro and in vivo antitumor activity.
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spelling Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae)Óleos VoláteisGuatteriaGuatteria pogonopus Martius , a plant belonging to the Annonaceae family, is found in the remaining Brazilian Atlantic Forest. In this study, the chemical composition and antitumor effects of the essential oil isolated from leaves of G. pogonopus was investigated. The chemical composition of the oil was determined by GC-FID and GC/MS analyses. The in vitro cytotoxicity was evaluated against three different tumor cell lines (OVCAR-8, NCI-H358M, and PC-3M), and the in vivo antitumor activity was tested in mice bearing sarcoma 180 tumor. A total of 29 compounds was identified and quantified in the oil. The major compounds were g -patchoulene (13.55%), ( E )-caryophyllene (11.36%), b -pinene (10.37%), germacrene D (6.72%), bicyclogermacrene (5.97%), a -pinene (5.33%), and germacrene B (4.69%). The essential oil, but neither ( E )-caryophyllene nor b -pinene, displayed in vitro cytotoxicity against all three tumor cell lines tested. The obtained average IC 50 values ranged from 3.8 to 20.8 m g/ml. The lowest and highest values were obtained against the NCI-H358M and the OVCAR-8 cell lines, respectively. The in vivo tumor-growth-inhibition rates in the tumor-bearing mice treated with essential oil (50 and 100 mg/kg/d) were 25.3 and 42.6%, respectively. Hence, the essential oil showed significant in vitro and in vivo antitumor activity.Chemistry & Biodiversity2013-07-18T15:27:42Z2013-07-18T15:27:42Z2013-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfFONTES, J. E. N. et al. Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae. Chemistry & Biodiversity, v. 10, n. 4, p. 722-729, abr. 2013.1612-1872 Impressa1612-1880 On linehttp://www.repositorio.ufc.br/handle/riufc/5437Fontes, José Eraldo do N.Ferraz, Rosana P. C.Britto, Anny C. S.Carvalho, Adriana A.Moraes Filho, Manoel Odorico dePessoa, ClaudiaCosta, Emmanoel V.Bezerra, Daniel P.engreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-11-10T23:07:01Zoai:repositorio.ufc.br:riufc/5437Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:51:21.779137Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae)
title Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae)
spellingShingle Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae)
Fontes, José Eraldo do N.
Óleos Voláteis
Guatteria
title_short Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae)
title_full Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae)
title_fullStr Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae)
title_full_unstemmed Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae)
title_sort Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae)
author Fontes, José Eraldo do N.
author_facet Fontes, José Eraldo do N.
Ferraz, Rosana P. C.
Britto, Anny C. S.
Carvalho, Adriana A.
Moraes Filho, Manoel Odorico de
Pessoa, Claudia
Costa, Emmanoel V.
Bezerra, Daniel P.
author_role author
author2 Ferraz, Rosana P. C.
Britto, Anny C. S.
Carvalho, Adriana A.
Moraes Filho, Manoel Odorico de
Pessoa, Claudia
Costa, Emmanoel V.
Bezerra, Daniel P.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fontes, José Eraldo do N.
Ferraz, Rosana P. C.
Britto, Anny C. S.
Carvalho, Adriana A.
Moraes Filho, Manoel Odorico de
Pessoa, Claudia
Costa, Emmanoel V.
Bezerra, Daniel P.
dc.subject.por.fl_str_mv Óleos Voláteis
Guatteria
topic Óleos Voláteis
Guatteria
description Guatteria pogonopus Martius , a plant belonging to the Annonaceae family, is found in the remaining Brazilian Atlantic Forest. In this study, the chemical composition and antitumor effects of the essential oil isolated from leaves of G. pogonopus was investigated. The chemical composition of the oil was determined by GC-FID and GC/MS analyses. The in vitro cytotoxicity was evaluated against three different tumor cell lines (OVCAR-8, NCI-H358M, and PC-3M), and the in vivo antitumor activity was tested in mice bearing sarcoma 180 tumor. A total of 29 compounds was identified and quantified in the oil. The major compounds were g -patchoulene (13.55%), ( E )-caryophyllene (11.36%), b -pinene (10.37%), germacrene D (6.72%), bicyclogermacrene (5.97%), a -pinene (5.33%), and germacrene B (4.69%). The essential oil, but neither ( E )-caryophyllene nor b -pinene, displayed in vitro cytotoxicity against all three tumor cell lines tested. The obtained average IC 50 values ranged from 3.8 to 20.8 m g/ml. The lowest and highest values were obtained against the NCI-H358M and the OVCAR-8 cell lines, respectively. The in vivo tumor-growth-inhibition rates in the tumor-bearing mice treated with essential oil (50 and 100 mg/kg/d) were 25.3 and 42.6%, respectively. Hence, the essential oil showed significant in vitro and in vivo antitumor activity.
publishDate 2013
dc.date.none.fl_str_mv 2013-07-18T15:27:42Z
2013-07-18T15:27:42Z
2013-04
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv FONTES, J. E. N. et al. Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae. Chemistry & Biodiversity, v. 10, n. 4, p. 722-729, abr. 2013.
1612-1872 Impressa
1612-1880 On line
http://www.repositorio.ufc.br/handle/riufc/5437
identifier_str_mv FONTES, J. E. N. et al. Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae. Chemistry & Biodiversity, v. 10, n. 4, p. 722-729, abr. 2013.
1612-1872 Impressa
1612-1880 On line
url http://www.repositorio.ufc.br/handle/riufc/5437
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Chemistry & Biodiversity
publisher.none.fl_str_mv Chemistry & Biodiversity
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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