Human endogenous retrovirus K activation in the lower respiratory tract of severe COVID-19 patients associates with early mortality

Temerozo, Jairo Ramos; Fintelman-Rodrigues, Natalia; Santos, Monique Cristina; Hottz, Eugênio; Sacramento, Carolina; Silva, Aline; Mandacaru, Samuel; Moraes, Emilly Caroline; Trugilho, Monique; Gesto, João; Ferreira, Marcelo; Betoni, Felipe; Martins-Gonçalves, Remy; Quintanilha, Isaclaudia Gomes de Azevedo; Abrantes, Juliana L.; Righy, Cassia; Kurtz, Pedro; Jiang, Hui; Tan, Hongdong; Morel, Carlos Medicis; Bou-Habib, Dumith Chequer; Bozza, Fernando A.; Bozza, Patrícia Torres; Souza, Thiago Moreno L.

Human endogenous retrovirus K activation in the lower respiratory tract of severe COVID-19 patients associates with early mortality

Detalhes bibliográficos
Autor(a) principal:	Temerozo, Jairo Ramos
Data de Publicação:	2021
Outros Autores:	Fintelman-Rodrigues, Natalia, Santos, Monique Cristina, Hottz, Eugênio, Sacramento, Carolina, Silva, Aline, Mandacaru, Samuel, Moraes, Emilly Caroline, Trugilho, Monique, Gesto, João, Ferreira, Marcelo, Betoni, Felipe, Martins-Gonçalves, Remy, Quintanilha, Isaclaudia Gomes de Azevedo, Abrantes, Juliana L., Righy, Cassia, Kurtz, Pedro, Jiang, Hui, Tan, Hongdong, Morel, Carlos Medicis, Bou-Habib, Dumith Chequer, Bozza, Fernando A., Bozza, Patrícia Torres, Souza, Thiago Moreno L.
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/47842
Resumo:	This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.

Metadados do item

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network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Temerozo, Jairo RamosFintelman-Rodrigues, NataliaSantos, Monique CristinaHottz, EugênioSacramento, CarolinaSilva, AlineMandacaru, SamuelMoraes, Emilly CarolineTrugilho, MoniqueGesto, JoãoFerreira, MarceloBetoni, FelipeMartins-Gonçalves, RemyQuintanilha, Isaclaudia Gomes de AzevedoAbrantes, Juliana L.Righy, CassiaKurtz, PedroJiang, HuiTan, HongdongMorel, Carlos MedicisBou-Habib, Dumith ChequerBozza, Fernando A.Bozza, Patrícia TorresSouza, Thiago Moreno L.2021-06-22T18:09:56Z2021-06-22T18:09:56Z2021TEMEROZO, Jairo et al. Human endogenous retrovirus K activation in the lower respiratory tract of severe COVID-19 patients associates with early mortality. Research Square, p. 1-37, 2021.https://www.arca.fiocruz.br/handle/icict/47842This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa do Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Instituto Nacional de Ciência e Tecnologia para Inovação em Doenças Negligenciadas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Instituto Nacional de Ciência e Tecnologia para Inovação em Doenças Negligenciadas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Federal de Juiz de Fora. Departamento de Bioquímica. Laboratório de Imunotrombose. Juiz de Fora, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Federal de Juiz de Fora. Departamento de Bioquímica. Laboratório de Imunotrombose. Juiz de Fora, MG, Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Instituto Nacional de Ciência e Tecnologia para Inovação em Doenças Negligenciadas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Instituto Nacional de Ciência e Tecnologia para Inovação em Doenças Negligenciadas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Instituto Nacional de Ciência e Tecnologia para Inovação em Doenças Negligenciadas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Instituto Nacional de Ciência e Tecnologia para Inovação em Doenças Negligenciadas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evandro Chagas. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil / Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.lMGI Tech Co. Ltd. Beishan Industrial Zone, Yantian District, Shenzhen, China.lMGI Tech Co. Ltd. Beishan Industrial Zone, Yantian District, Shenzhen, China.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Instituto Nacional de Ciência e Tecnologia para Inovação em Doenças Negligenciadas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa do Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evandro Chagas. Rio de Janeiro, RJ, Brasil / Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Instituto Nacional de Ciência e Tecnologia para Inovação em Doenças Negligenciadas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Instituto Nacional de Ciência e Tecnologia para Inovação em Doenças Negligenciadas. Rio de Janeiro, RJ, Brasil.Critically ill 2019 coronavirus disease patients (COVID-19) under invasive mechanical ventilation (IMV) are 10- to 40-times more likely to die than the general population. Although progression from mild to severe COVID-19 has been associated with hypoxia, uncontrolled inflammation and coagulopathy, the mechanisms involved in progression to severity are poorly understood. By analyzing the virome from tracheal aspirates (TA) of 25 COVID-19 patients under IMV, we found higher levels and differential expression of human endogenous retrovirus K (HERV-K) genes compared to nasopharyngeal swabs from mild cases and TA from non-COVID patients. Proteomic analysis and RT-PCR confirmed the presence of HERV-K in these patients. Moreover, increased HERV-K expression was triggered in human primary monocytes from healthy donors after experimental SARS-CoV-2 infection in vitro. In critically ill patients, higher HERV-K levels were associated with early mortality (within 14 days) in the intensive care unit. Increased HERV-K expression in deceased patients associated with IL-17-related inflammation, monocyte activation and higher consumption of clotting/fibrinolysis factors. Our data implicate the levels of HERV-K transcripts in the outcome of critical COVID-19 patients under invasive mechanical ventilation.engResearch SquareCOVID-19SARS-CoV-2HERV-KCOVID-19SARS-CoV-2HERV-KHuman endogenous retrovirus K activation in the lower respiratory tract of severe COVID-19 patients associates with early mortalityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv	Human endogenous retrovirus K activation in the lower respiratory tract of severe COVID-19 patients associates with early mortality
title	Human endogenous retrovirus K activation in the lower respiratory tract of severe COVID-19 patients associates with early mortality
spellingShingle	Human endogenous retrovirus K activation in the lower respiratory tract of severe COVID-19 patients associates with early mortality Temerozo, Jairo Ramos COVID-19 SARS-CoV-2 HERV-K COVID-19 SARS-CoV-2 HERV-K
title_short	Human endogenous retrovirus K activation in the lower respiratory tract of severe COVID-19 patients associates with early mortality
title_full	Human endogenous retrovirus K activation in the lower respiratory tract of severe COVID-19 patients associates with early mortality
title_fullStr	Human endogenous retrovirus K activation in the lower respiratory tract of severe COVID-19 patients associates with early mortality
title_full_unstemmed	Human endogenous retrovirus K activation in the lower respiratory tract of severe COVID-19 patients associates with early mortality
title_sort	Human endogenous retrovirus K activation in the lower respiratory tract of severe COVID-19 patients associates with early mortality
author	Temerozo, Jairo Ramos
author_facet	Temerozo, Jairo Ramos Fintelman-Rodrigues, Natalia Santos, Monique Cristina Hottz, Eugênio Sacramento, Carolina Silva, Aline Mandacaru, Samuel Moraes, Emilly Caroline Trugilho, Monique Gesto, João Ferreira, Marcelo Betoni, Felipe Martins-Gonçalves, Remy Quintanilha, Isaclaudia Gomes de Azevedo Abrantes, Juliana L. Righy, Cassia Kurtz, Pedro Jiang, Hui Tan, Hongdong Morel, Carlos Medicis Bou-Habib, Dumith Chequer Bozza, Fernando A. Bozza, Patrícia Torres Souza, Thiago Moreno L.
author_role	author
author2	Fintelman-Rodrigues, Natalia Santos, Monique Cristina Hottz, Eugênio Sacramento, Carolina Silva, Aline Mandacaru, Samuel Moraes, Emilly Caroline Trugilho, Monique Gesto, João Ferreira, Marcelo Betoni, Felipe Martins-Gonçalves, Remy Quintanilha, Isaclaudia Gomes de Azevedo Abrantes, Juliana L. Righy, Cassia Kurtz, Pedro Jiang, Hui Tan, Hongdong Morel, Carlos Medicis Bou-Habib, Dumith Chequer Bozza, Fernando A. Bozza, Patrícia Torres Souza, Thiago Moreno L.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Temerozo, Jairo Ramos Fintelman-Rodrigues, Natalia Santos, Monique Cristina Hottz, Eugênio Sacramento, Carolina Silva, Aline Mandacaru, Samuel Moraes, Emilly Caroline Trugilho, Monique Gesto, João Ferreira, Marcelo Betoni, Felipe Martins-Gonçalves, Remy Quintanilha, Isaclaudia Gomes de Azevedo Abrantes, Juliana L. Righy, Cassia Kurtz, Pedro Jiang, Hui Tan, Hongdong Morel, Carlos Medicis Bou-Habib, Dumith Chequer Bozza, Fernando A. Bozza, Patrícia Torres Souza, Thiago Moreno L.
dc.subject.other.pt_BR.fl_str_mv	COVID-19 SARS-CoV-2 HERV-K
topic	COVID-19 SARS-CoV-2 HERV-K COVID-19 SARS-CoV-2 HERV-K
dc.subject.en.pt_BR.fl_str_mv	COVID-19 SARS-CoV-2 HERV-K
description	This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
publishDate	2021
dc.date.accessioned.fl_str_mv	2021-06-22T18:09:56Z
dc.date.available.fl_str_mv	2021-06-22T18:09:56Z
dc.date.issued.fl_str_mv	2021
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	TEMEROZO, Jairo et al. Human endogenous retrovirus K activation in the lower respiratory tract of severe COVID-19 patients associates with early mortality. Research Square, p. 1-37, 2021.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/47842
identifier_str_mv	TEMEROZO, Jairo et al. Human endogenous retrovirus K activation in the lower respiratory tract of severe COVID-19 patients associates with early mortality. Research Square, p. 1-37, 2021.
url	https://www.arca.fiocruz.br/handle/icict/47842
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Research Square
publisher.none.fl_str_mv	Research Square
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/47842/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/47842/2/v1_preprint_Human_endogenous_retrovirus_K.pdf https://www.arca.fiocruz.br/bitstream/icict/47842/3/v1_preprint_Human_endogenous_retrovirus_K.pdf.txt
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Human endogenous retrovirus K activation in the lower respiratory tract of severe COVID-19 patients associates with early mortality

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