Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution

Detalhes bibliográficos
Autor(a) principal: Kasprowicz, Victoria
Data de Publicação: 2010
Outros Autores: Kang, Yu-Hoi, Lucas, Michaela, Schulze zur Wiesch, Julian, Kuntzen, Thomas, Fleming, Vicki, Nolan, Brian E., Longworth, Steven, Berical, Andrew, Bengsch, Bertram, Thimme, Robert, Lewis-Ximenez, Lia, Allen, Todd M., Kim, Arthur Y., Klenerman, Paul, Lauer, Georg M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16889
Resumo: Harvard Medical School. Massachusetts General Hospital. Boston, MA, USA / Massachusetts Institute of Technology. Ragon Institute of Massachusetts General Hospital. Boston, MA, USA.
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spelling Kasprowicz, VictoriaKang, Yu-HoiLucas, MichaelaSchulze zur Wiesch, JulianKuntzen, ThomasFleming, VickiNolan, Brian E.Longworth, StevenBerical, AndrewBengsch, BertramThimme, RobertLewis-Ximenez, LiaAllen, Todd M.Kim, Arthur Y.Klenerman, PaulLauer, Georg M.2017-01-18T13:15:27Z2017-01-18T13:15:27Z2010KASPROWICZ, Victoria; et al. Hepatitis C Virus (HCV) Sequence Variation Induces an HCV-Specific T-Cell Phenotype Analogous to Spontaneous Resolution . Journal of Virology, v.84, n.3, p.1656-1663, Feb. 2010.0022-538Xhttps://www.arca.fiocruz.br/handle/icict/1688910.1128/JVI.01499-091098-5514engAmerican Society for MicrobiologyVirus da Hepatite VInfecçãoHepatitis C Virus (HCV)HCV infectionHepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolutioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHarvard Medical School. Massachusetts General Hospital. Boston, MA, USA / Massachusetts Institute of Technology. Ragon Institute of Massachusetts General Hospital. Boston, MA, USA.University of Oxford. Nuffield Department of Medicine. Peter Medawar Building for Pathogen Research. Oxford, United Kingdom.University of Oxford. Nuffield Department of Medicine. Peter Medawar Building for Pathogen Research. Oxford, United Kingdom.Harvard Medical School. Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA.Harvard Medical School. Massachusetts General Hospital. Boston, MA, USA / Massachusetts Institute of Technology. Ragon Institute of Massachusetts General Hospital. Boston, MA, USA.University of Oxford. Nuffield Department of Medicine. Peter Medawar Building for Pathogen Research. Oxford, United Kingdom.Harvard Medical School. Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA.Harvard Medical School. Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA.Harvard Medical School. Massachusetts General Hospital. Boston, MA, USA / Massachusetts Institute of Technology. Ragon Institute of Massachusetts General Hospital. Boston, MA, USA.Universitaet Freiburg. Medizinische Klinik. Freiburg, Germany.Universitaet Freiburg. Medizinische Klinik. Freiburg, Germany.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ. Brasil.Harvard Medical School. Massachusetts General Hospital. Boston, MA, USA / Massachusetts Institute of Technology. Ragon Institute of Massachusetts General Hospital. Boston, MA, USA.Harvard Medical School. Massachusetts General Hospital. Boston, MA, USA / Massachusetts Institute of Technology. Ragon Institute of Massachusetts General Hospital. Boston, MA, USA.University of Oxford. Nuffield Department of Medicine. Peter Medawar Building for Pathogen Research. Oxford, United Kingdom.Harvard Medical School. Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA.Hepatitis C virus (HCV)-specific CD8(+) T cells in persistent HCV infection are low in frequency and paradoxically show a phenotype associated with controlled infections, expressing the memory marker CD127. We addressed to what extent this phenotype is dependent on the presence of cognate antigen. We analyzed virus-specific responses in acute and chronic HCV infections and sequenced autologous virus. We show that CD127 expression is associated with decreased antigenic stimulation after either viral clearance or viral variation. Our data indicate that most CD8 T-cell responses in chronic HCV infection do not target the circulating virus and that the appearance of HCV-specific CD127(+) T cells is driven by viral variation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16889/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALlia_ximenez_etal_IOC_2010.pdflia_ximenez_etal_IOC_2010.pdfapplication/pdf1844567https://www.arca.fiocruz.br/bitstream/icict/16889/2/lia_ximenez_etal_IOC_2010.pdfbc763bb008cf309442675a213b9efbd5MD52TEXTlia_ximenez_etal_IOC_2010.pdf.txtlia_ximenez_etal_IOC_2010.pdf.txtExtracted texttext/plain25137https://www.arca.fiocruz.br/bitstream/icict/16889/3/lia_ximenez_etal_IOC_2010.pdf.txt3c70c94b9394aeb2aad38320aaf897d0MD53icict/168892018-08-15 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dc.title.pt_BR.fl_str_mv Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution
title Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution
spellingShingle Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution
Kasprowicz, Victoria
Virus da Hepatite V
Infecção
Hepatitis C Virus (HCV)
HCV infection
title_short Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution
title_full Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution
title_fullStr Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution
title_full_unstemmed Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution
title_sort Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution
author Kasprowicz, Victoria
author_facet Kasprowicz, Victoria
Kang, Yu-Hoi
Lucas, Michaela
Schulze zur Wiesch, Julian
Kuntzen, Thomas
Fleming, Vicki
Nolan, Brian E.
Longworth, Steven
Berical, Andrew
Bengsch, Bertram
Thimme, Robert
Lewis-Ximenez, Lia
Allen, Todd M.
Kim, Arthur Y.
Klenerman, Paul
Lauer, Georg M.
author_role author
author2 Kang, Yu-Hoi
Lucas, Michaela
Schulze zur Wiesch, Julian
Kuntzen, Thomas
Fleming, Vicki
Nolan, Brian E.
Longworth, Steven
Berical, Andrew
Bengsch, Bertram
Thimme, Robert
Lewis-Ximenez, Lia
Allen, Todd M.
Kim, Arthur Y.
Klenerman, Paul
Lauer, Georg M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kasprowicz, Victoria
Kang, Yu-Hoi
Lucas, Michaela
Schulze zur Wiesch, Julian
Kuntzen, Thomas
Fleming, Vicki
Nolan, Brian E.
Longworth, Steven
Berical, Andrew
Bengsch, Bertram
Thimme, Robert
Lewis-Ximenez, Lia
Allen, Todd M.
Kim, Arthur Y.
Klenerman, Paul
Lauer, Georg M.
dc.subject.other.pt_BR.fl_str_mv Virus da Hepatite V
Infecção
topic Virus da Hepatite V
Infecção
Hepatitis C Virus (HCV)
HCV infection
dc.subject.en.pt_BR.fl_str_mv Hepatitis C Virus (HCV)
HCV infection
description Harvard Medical School. Massachusetts General Hospital. Boston, MA, USA / Massachusetts Institute of Technology. Ragon Institute of Massachusetts General Hospital. Boston, MA, USA.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2017-01-18T13:15:27Z
dc.date.available.fl_str_mv 2017-01-18T13:15:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv KASPROWICZ, Victoria; et al. Hepatitis C Virus (HCV) Sequence Variation Induces an HCV-Specific T-Cell Phenotype Analogous to Spontaneous Resolution . Journal of Virology, v.84, n.3, p.1656-1663, Feb. 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16889
dc.identifier.issn.pt_BR.fl_str_mv 0022-538X
dc.identifier.doi.none.fl_str_mv 10.1128/JVI.01499-09
dc.identifier.eissn.none.fl_str_mv 1098-5514
identifier_str_mv KASPROWICZ, Victoria; et al. Hepatitis C Virus (HCV) Sequence Variation Induces an HCV-Specific T-Cell Phenotype Analogous to Spontaneous Resolution . Journal of Virology, v.84, n.3, p.1656-1663, Feb. 2010.
0022-538X
10.1128/JVI.01499-09
1098-5514
url https://www.arca.fiocruz.br/handle/icict/16889
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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