HCV/HTLV coinfection: Does HTLV-1 interfere in the natural history of HCV-related diseases?
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1002/jmv.24538 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18305 |
Resumo: | Edgard Marcelino de Carvalho Filho. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. "Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento". |
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Silva, Marcelo CostaSilva, Carolina Alves CostaMachado, Gustavo UzêdaAtta, Ajax MercêsFreire, Songeli MCarvalho Filho, Edgar MarcelinoSchinoni, Maria IsabelParaná, Raymundo2017-04-07T13:05:39Z2017-04-07T13:05:39Z2016SILVA, M. C. et al. HCV/HTLV coinfection: Does HTLV-1 interfere in the natural history of HCV-related diseases? Journal of Medical Virology, v. 88, p. 1967–1972, 2016.0146-6615https://www.arca.fiocruz.br/handle/icict/1830510.1002/jmv.24538Edgard Marcelino de Carvalho Filho. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. "Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento".CNPq (Universal); Grant sponsor: LIA ProjectFederal University of Bahia. Department of Hepatology. Salvador, BA, BrazilFederal University of Bahia. Department of Hepatology. Salvador, BA, BrazilFederal University of Bahia. Department of Hepatology. Salvador, BA, BrazilFederal University of Bahia. Clinical and Toxicological Analysis. Salvador, BA, BrazilFederal University of Bahia. Immunology Laboratory of the Health Science Institute. Salvador, BA, BrazilFederal University of Bahia. Immunology Service of the University Hospital Professor Edgar Santos. Salvador, BA, BrazilFederal University of Bahia. Hepatology Center of the University Hospital Professor Edgar Santos. Salvador, BA, BrazilFederal University of Bahia. Hepatology Center of the University Hospital Professor Edgar Santos. Salvador, BA, BrazilHepatitis C virus (HCV) and human T-lymphotropic virus type 1 (HTLV-1) coinfection occurs in many regions. However, few studies have focused on the natural history of HCV-induced liver disease in coinfected patients. To describe the clinical, epidemiological, and histopathological aspects of HTLV-1/HCV coinfection in Brazil. A cross-sectional study with 23 patients coinfected with HCV/HTLV. The control groups consisted of 21 patients monoinfected with HCV and 20 patients monoinfected with HTLV-1. The cytokine profiles (Th1 and Th2 cell responses), clinical, laboratory features, and histopathological aspects were examined. The control group for cytokine analysis validation consisted of patients monoinfected with HTLV, and a fourth group consisted of healthy blood donors. No anthropometric differences present between the three infected groups. We observed higher serum concentrations of IFN-γ in patients coinfected with HCV/HTLV-1 than those in HCV monoinfected patients. The HCV/HTLV-1 coinfected group also exhibited a higher degree of liver steatosis than the HCV monoinfected patients. Results suggest that HCV/HTLV-1 coinfection may result in a different pattern of HCV infection due to the immunologic disorders likely associated with HTLV-1, but there is no clear evidence of the HTLV role in the natural history of HCV infection.engWileyCitocinasEpidemiologiaVírus da hepatite CVírus T-linfotrópico do tipo 1HCVCytokinesEpidemiologyHepatitis C virusT-lymphotropic virus type 1HCVHCV/HTLV coinfection: Does HTLV-1 interfere in the natural history of HCV-related diseases?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18305/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSilva MC HCV HTLV coinfection....pdfSilva MC HCV HTLV 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| dc.title.pt_BR.fl_str_mv |
HCV/HTLV coinfection: Does HTLV-1 interfere in the natural history of HCV-related diseases? |
| title |
HCV/HTLV coinfection: Does HTLV-1 interfere in the natural history of HCV-related diseases? |
| spellingShingle |
HCV/HTLV coinfection: Does HTLV-1 interfere in the natural history of HCV-related diseases? Silva, Marcelo Costa Citocinas Epidemiologia Vírus da hepatite C Vírus T-linfotrópico do tipo 1 HCV Cytokines Epidemiology Hepatitis C virus T-lymphotropic virus type 1 HCV |
| title_short |
HCV/HTLV coinfection: Does HTLV-1 interfere in the natural history of HCV-related diseases? |
| title_full |
HCV/HTLV coinfection: Does HTLV-1 interfere in the natural history of HCV-related diseases? |
| title_fullStr |
HCV/HTLV coinfection: Does HTLV-1 interfere in the natural history of HCV-related diseases? |
| title_full_unstemmed |
HCV/HTLV coinfection: Does HTLV-1 interfere in the natural history of HCV-related diseases? |
| title_sort |
HCV/HTLV coinfection: Does HTLV-1 interfere in the natural history of HCV-related diseases? |
| author |
Silva, Marcelo Costa |
| author_facet |
Silva, Marcelo Costa Silva, Carolina Alves Costa Machado, Gustavo Uzêda Atta, Ajax Mercês Freire, Songeli M Carvalho Filho, Edgar Marcelino Schinoni, Maria Isabel Paraná, Raymundo |
| author_role |
author |
| author2 |
Silva, Carolina Alves Costa Machado, Gustavo Uzêda Atta, Ajax Mercês Freire, Songeli M Carvalho Filho, Edgar Marcelino Schinoni, Maria Isabel Paraná, Raymundo |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Marcelo Costa Silva, Carolina Alves Costa Machado, Gustavo Uzêda Atta, Ajax Mercês Freire, Songeli M Carvalho Filho, Edgar Marcelino Schinoni, Maria Isabel Paraná, Raymundo |
| dc.subject.other.pt_BR.fl_str_mv |
Citocinas Epidemiologia Vírus da hepatite C Vírus T-linfotrópico do tipo 1 HCV |
| topic |
Citocinas Epidemiologia Vírus da hepatite C Vírus T-linfotrópico do tipo 1 HCV Cytokines Epidemiology Hepatitis C virus T-lymphotropic virus type 1 HCV |
| dc.subject.en.pt_BR.fl_str_mv |
Cytokines Epidemiology Hepatitis C virus T-lymphotropic virus type 1 HCV |
| description |
Edgard Marcelino de Carvalho Filho. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. "Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento". |
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2016 |
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2016 |
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2017-04-07T13:05:39Z |
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2017-04-07T13:05:39Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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SILVA, M. C. et al. HCV/HTLV coinfection: Does HTLV-1 interfere in the natural history of HCV-related diseases? Journal of Medical Virology, v. 88, p. 1967–1972, 2016. |
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https://www.arca.fiocruz.br/handle/icict/18305 |
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0146-6615 |
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10.1002/jmv.24538 |
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SILVA, M. C. et al. HCV/HTLV coinfection: Does HTLV-1 interfere in the natural history of HCV-related diseases? Journal of Medical Virology, v. 88, p. 1967–1972, 2016. 0146-6615 10.1002/jmv.24538 |
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