Cholinesterase inhibition reduces arrhythmias in asymptomatic Chagas disease

Detalhes bibliográficos
Autor(a) principal: Castro, R. R. T.
Data de Publicação: 2017
Outros Autores: Porphirio, G., Xavier, S. S., Moraes, R. S., Ferlin, E. L., Ribeiro, J. P., Nóbrega, A. C. L. da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34351
Resumo: Sergio S. Xavier. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Castro, R. R. T.Porphirio, G.Xavier, S. S.Moraes, R. S.Ferlin, E. L.Ribeiro, J. P.Nóbrega, A. C. L. da2019-07-23T14:44:34Z2019-07-23T14:44:34Z2017CASTRO, Renata R. T. et al. Cholinesterase inhibition reduces arrhythmias in asymptomatic Chagas disease. Cardiovascular Therapeutics, v. 35, p. 1-5, 2017.1755-5914https://www.arca.fiocruz.br/handle/icict/3435110.1111/1755-5922.122881755-5922Sergio S. Xavier. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2020-07-23Fluminense Federal University. Department of Physiology and Pharmacology and Post-Graduate Program in Cardiovascular Sciences. Niterói, RJ, Brazil.Rio de Janeiro Federal University. Division of Cardiology. Rio de Janeiro, RJ, Brazil.Rio de Janeiro Federal University. Division of Cardiology. Rio de Janeiro, RJ, Brazil.Rio Grande do Sul Federal University. Division of Cardiology. Porto Alegre, RS, Brazil.Rio Grande do Sul Federal University. Division of Cardiology. Porto Alegre, RS, Brazil.Rio Grande do Sul Federal University. Division of Cardiology. Porto Alegre, RS, Brazil.Fluminense Federal University. Department of Physiology and Pharmacology and Post-Graduate Program in Cardiovascular Sciences. Niterói, RJ, Brazil.Introduction: Parasympathetic dysfunction may play a role in the genesis of arrhyth-mias in Chagas disease. Aim: This study evaluates the acute effects of pyridostigmine (PYR), a reversible cholinest-erase inhibitor, on the occurrence of arrhythmias in patients with Chagas cardiac disease. Method: Following a double-blind, randomized, placebo- controlled, cross- over proto-col, 17 patients (age 50±2 years) with Chagas cardiac disease type B underwent 24- hour Holter recordings after oral administration of either pyridostigmine bromide (45 mg, 3 times/day) or placebo (PLA).Results: Pyridostigmine reduced the 24- hours incidence (median [25%- 75%]) of pre-mature ventricular beats—PLA: 2998 (1920- 4870), PYR: 2359 (940- 3253), P=.044; ventricular couplets—PLA: 84 (15- 159), PYR: 33 (6- 94), P=.046. Although the total number of nonsustained ventricular tachycardia in the entire group was not different (P=.19) between PLA (1 [0- 8]) and PYR (0 [0- 4]), there were fewer episodes under PYR in 72% of the patients presenting this type of arrhythmia (P=.033). Conclusion: Acute administration of pyridostigmine reduced the incidence of nonsus-tained ventricular arrhythmias in patients with Chagas cardiac disease. Further studies that address the use of pyridostigmine by patients with Chagas cardiac disease under a more prolonged follow- up are warranted.engWileyCholinesterase inhibition reduces arrhythmias in asymptomatic Chagas diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAntiarrhythmia drugsArrhythmiaAutonomic diseasesChagas cardiomyopathyCholinesterasesParasympathetic nervous systeminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/34351/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Castro_Renata_etal_INI_2017.pdfve_Castro_Renata_etal_INI_2017.pdfapplication/pdf296008https://www.arca.fiocruz.br/bitstream/icict/34351/2/ve_Castro_Renata_etal_INI_2017.pdf2204527e149681bb2e2da5902e94bf08MD52TEXTve_Castro_Renata_etal_INI_2017.pdf.txtve_Castro_Renata_etal_INI_2017.pdf.txtExtracted texttext/plain26278https://www.arca.fiocruz.br/bitstream/icict/34351/3/ve_Castro_Renata_etal_INI_2017.pdf.txt37b4def0f0a02ac6d791678a364cc11cMD53icict/343512021-03-24 16:32:34.525oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:34Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Cholinesterase inhibition reduces arrhythmias in asymptomatic Chagas disease
title Cholinesterase inhibition reduces arrhythmias in asymptomatic Chagas disease
spellingShingle Cholinesterase inhibition reduces arrhythmias in asymptomatic Chagas disease
Castro, R. R. T.
Antiarrhythmia drugs
Arrhythmia
Autonomic diseases
Chagas cardiomyopathy
Cholinesterases
Parasympathetic nervous system
title_short Cholinesterase inhibition reduces arrhythmias in asymptomatic Chagas disease
title_full Cholinesterase inhibition reduces arrhythmias in asymptomatic Chagas disease
title_fullStr Cholinesterase inhibition reduces arrhythmias in asymptomatic Chagas disease
title_full_unstemmed Cholinesterase inhibition reduces arrhythmias in asymptomatic Chagas disease
title_sort Cholinesterase inhibition reduces arrhythmias in asymptomatic Chagas disease
author Castro, R. R. T.
author_facet Castro, R. R. T.
Porphirio, G.
Xavier, S. S.
Moraes, R. S.
Ferlin, E. L.
Ribeiro, J. P.
Nóbrega, A. C. L. da
author_role author
author2 Porphirio, G.
Xavier, S. S.
Moraes, R. S.
Ferlin, E. L.
Ribeiro, J. P.
Nóbrega, A. C. L. da
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Castro, R. R. T.
Porphirio, G.
Xavier, S. S.
Moraes, R. S.
Ferlin, E. L.
Ribeiro, J. P.
Nóbrega, A. C. L. da
dc.subject.en.pt_BR.fl_str_mv Antiarrhythmia drugs
Arrhythmia
Autonomic diseases
Chagas cardiomyopathy
Cholinesterases
Parasympathetic nervous system
topic Antiarrhythmia drugs
Arrhythmia
Autonomic diseases
Chagas cardiomyopathy
Cholinesterases
Parasympathetic nervous system
description Sergio S. Xavier. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2019-07-23T14:44:34Z
dc.date.available.fl_str_mv 2019-07-23T14:44:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CASTRO, Renata R. T. et al. Cholinesterase inhibition reduces arrhythmias in asymptomatic Chagas disease. Cardiovascular Therapeutics, v. 35, p. 1-5, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34351
dc.identifier.issn.pt_BR.fl_str_mv 1755-5914
dc.identifier.doi.none.fl_str_mv 10.1111/1755-5922.12288
dc.identifier.eissn.none.fl_str_mv 1755-5922
identifier_str_mv CASTRO, Renata R. T. et al. Cholinesterase inhibition reduces arrhythmias in asymptomatic Chagas disease. Cardiovascular Therapeutics, v. 35, p. 1-5, 2017.
1755-5914
10.1111/1755-5922.12288
1755-5922
url https://www.arca.fiocruz.br/handle/icict/34351
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Wiley
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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