Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit

Duque, Maria Cristina de Oliveira; Silva, José Jayme Quintão; Soares, Priscilla Andrade Oliveira; Magalhães, Rodrigo Sousa; Horta, Adriene Paiva Araújo; Paes, Lucia Regina Brahim; Lyra, Marcelo Rosandiski; Pimentel, Maria Inês Fernandes; Antonio, Liliane de Fátima; Vasconcellos, Érica de Camargo Ferreira e; Saheki, Maurício Naoto; Marzochi, Mauro Celio de Almeida; Valete-Rosalino, Cláudia Maria; Schubach, Armando de Oliveira

Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit

Detalhes bibliográficos
Autor(a) principal:	Duque, Maria Cristina de Oliveira
Data de Publicação:	2019
Outros Autores:	Silva, José Jayme Quintão, Soares, Priscilla Andrade Oliveira, Magalhães, Rodrigo Sousa, Horta, Adriene Paiva Araújo, Paes, Lucia Regina Brahim, Lyra, Marcelo Rosandiski, Pimentel, Maria Inês Fernandes, Antonio, Liliane de Fátima, Vasconcellos, Érica de Camargo Ferreira e, Saheki, Maurício Naoto, Marzochi, Mauro Celio de Almeida, Valete-Rosalino, Cláudia Maria, Schubach, Armando de Oliveira
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/32242
Resumo:	2020-03-07

Metadados do item

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network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Duque, Maria Cristina de OliveiraSilva, José Jayme QuintãoSoares, Priscilla Andrade OliveiraMagalhães, Rodrigo SousaHorta, Adriene Paiva AraújoPaes, Lucia Regina BrahimLyra, Marcelo RosandiskiPimentel, Maria Inês FernandesAntonio, Liliane de FátimaVasconcellos, Érica de Camargo Ferreira eSaheki, Maurício NaotoMarzochi, Mauro Celio de AlmeidaValete-Rosalino, Cláudia MariaSchubach, Armando de Oliveira2019-03-27T13:04:53Z2019-03-27T13:04:53Z2019DUQUE, Maria Cristina de Oliveira et al. Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit. Acta Tropica, v. 193, p. 176-182, 2019.0001-706Xhttps://www.arca.fiocruz.br/handle/icict/3224210.1016/j.actatropica.2019.03.007engElsevierComparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unitinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-03-07Secretaria Municipal de Saúde. Timóteo, MG, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Programa de Pós-Graduação Stricto Sensu em Pesquisa Clínica. Rio de Janeiro, RJ, Brasil.Secretaria Municipal de Saúde. Timóteo, MG, Brasil.Private Clinic. Coronel Fabriciano, MG, Brazil.Private Clinic. Ipatinga, MG, Brazil.Secretaria Municipal de Saúde. Timóteo, MG, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil / Fundação Técnico Educacional Souza Marques. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Programa de Produtividade em Pesquisa. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil /Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Departamento de Otorrinolaringologia e Oftalmologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Programa de Produtividade em Pesquisa. Brasília, DF, Brasil /Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro. Programa Cientista do Nosso Estado. Rio de Janeiro, RJ, Brasil.Cutaneous leishmaniasis (CL) is not a life-threatening condition. However, its treatment can cause serious adverse effects and may sometimes lead to death. Recently, safer local treatments have been included among therapies acceptable to New World CL cases, but the use of intralesional meglumine antimoniate (IL-MA) is recommended to be performed in reference centers, for patients with single cutaneous lesions < 3 cm in diameter at any location except the head and periarticular regions; the volume of injected MA should not exceed 5 mL. In this study we compared two groups of patients with CL treated with MA in a primary health care unit in Brazil. Patients were treated with systemic MA (n = 76) or IL-MA (n = 30). In the IL-MA group, 93% of patients had one or more of the following lesion characteristics: two or more lesions, lesions > 3 cm in diameter, lesions located in the head or in periarticular regions, or had been administered IL-MA volumes > 5 mL. Patients responded well (68.4% and 66.7% for the MA and IL-MA groups, respectively). When a second cycle of treatment was necessary, the responses were 72.4% and 90%, respectively. There were no significant differences between groups. In the IL-MA group, 43% had mild to moderate adverse effects, without needing treatment discontinuation. Results suggest that the treatment of CL lesions with IL-MA is simple, efficient, and safe.American tegumentary leishmaniasisCutaneous leishmaniasisTherapyMeglumine antimoniateIntralesionalinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/32242/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Duque_Maria_etal_INI_2019.pdfve_Duque_Maria_etal_INI_2019.pdfapplication/pdf692057https://www.arca.fiocruz.br/bitstream/icict/32242/2/ve_Duque_Maria_etal_INI_2019.pdf6ff025ebd53e613327433c522b87d1f3MD52TEXTve_Duque_Maria_etal_INI_2019.pdf.txtve_Duque_Maria_etal_INI_2019.pdf.txtExtracted texttext/plain48302https://www.arca.fiocruz.br/bitstream/icict/32242/3/ve_Duque_Maria_etal_INI_2019.pdf.txt6eb8781ec39a4f3c0eb4b2dea9ccf09cMD53icict/322422021-03-24 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dc.title.pt_BR.fl_str_mv	Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit
title	Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit
spellingShingle	Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit Duque, Maria Cristina de Oliveira American tegumentary leishmaniasis Cutaneous leishmaniasis Therapy Meglumine antimoniate Intralesional
title_short	Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit
title_full	Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit
title_fullStr	Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit
title_full_unstemmed	Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit
title_sort	Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit
author	Duque, Maria Cristina de Oliveira
author_facet	Duque, Maria Cristina de Oliveira Silva, José Jayme Quintão Soares, Priscilla Andrade Oliveira Magalhães, Rodrigo Sousa Horta, Adriene Paiva Araújo Paes, Lucia Regina Brahim Lyra, Marcelo Rosandiski Pimentel, Maria Inês Fernandes Antonio, Liliane de Fátima Vasconcellos, Érica de Camargo Ferreira e Saheki, Maurício Naoto Marzochi, Mauro Celio de Almeida Valete-Rosalino, Cláudia Maria Schubach, Armando de Oliveira
author_role	author
author2	Silva, José Jayme Quintão Soares, Priscilla Andrade Oliveira Magalhães, Rodrigo Sousa Horta, Adriene Paiva Araújo Paes, Lucia Regina Brahim Lyra, Marcelo Rosandiski Pimentel, Maria Inês Fernandes Antonio, Liliane de Fátima Vasconcellos, Érica de Camargo Ferreira e Saheki, Maurício Naoto Marzochi, Mauro Celio de Almeida Valete-Rosalino, Cláudia Maria Schubach, Armando de Oliveira
author2_role	author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Duque, Maria Cristina de Oliveira Silva, José Jayme Quintão Soares, Priscilla Andrade Oliveira Magalhães, Rodrigo Sousa Horta, Adriene Paiva Araújo Paes, Lucia Regina Brahim Lyra, Marcelo Rosandiski Pimentel, Maria Inês Fernandes Antonio, Liliane de Fátima Vasconcellos, Érica de Camargo Ferreira e Saheki, Maurício Naoto Marzochi, Mauro Celio de Almeida Valete-Rosalino, Cláudia Maria Schubach, Armando de Oliveira
dc.subject.en.pt_BR.fl_str_mv	American tegumentary leishmaniasis Cutaneous leishmaniasis Therapy Meglumine antimoniate Intralesional
topic	American tegumentary leishmaniasis Cutaneous leishmaniasis Therapy Meglumine antimoniate Intralesional
description	2020-03-07
publishDate	2019
dc.date.accessioned.fl_str_mv	2019-03-27T13:04:53Z
dc.date.available.fl_str_mv	2019-03-27T13:04:53Z
dc.date.issued.fl_str_mv	2019
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	DUQUE, Maria Cristina de Oliveira et al. Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit. Acta Tropica, v. 193, p. 176-182, 2019.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/32242
dc.identifier.issn.pt_BR.fl_str_mv	0001-706X
dc.identifier.doi.none.fl_str_mv	10.1016/j.actatropica.2019.03.007
identifier_str_mv	DUQUE, Maria Cristina de Oliveira et al. Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit. Acta Tropica, v. 193, p. 176-182, 2019. 0001-706X 10.1016/j.actatropica.2019.03.007
url	https://www.arca.fiocruz.br/handle/icict/32242
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/32242/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/32242/2/ve_Duque_Maria_etal_INI_2019.pdf https://www.arca.fiocruz.br/bitstream/icict/32242/3/ve_Duque_Maria_etal_INI_2019.pdf.txt
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bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit

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