Reanalysis And Integration Of Public Microarray Datasets Reveals Novel Host Genes Modulated In Leprosy

Detalhes bibliográficos
Autor(a) principal: Calvo, Thyago Leal
Data de Publicação: 2019
Outros Autores: Moraes, Milton Ozório
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/45064
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
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spelling Calvo, Thyago LealMoraes, Milton Ozório2020-12-21T20:16:21Z2020-12-21T20:16:21Z2019CALVO, Thiago Leal; MORAES, Milton Ozório. Reanalysis and integration of public microarray datasets reveals novel host genes modulated in Leprosy. bioRxiv, p. 1-23, 2019.1617-4615https://www.arca.fiocruz.br/handle/icict/4506410.1101/8248051617-4623engSpringerReanáliseDados públicosMicroarrayNovos genes hospedeirosHanseníaseLeprosyReanalysisPublic DatasetsMicroarrayNovel Host GenesReanalysis And Integration Of Public Microarray Datasets Reveals Novel Host Genes Modulated In Leprosyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Leprosy is an insidious disease caused primarily by mycobacteria. The difficulties in culturing this slow-growing bacteria together with the chronic progression of the disease have hampered the development of accurate methods for diagnosis. Host gene expression profiling is an important tool to assess overall tissue activity, whether in health or disease conditions. High-throughput gene expression experiments have become popular over the last decade or so, and public databases have been created to easily store and retrieve these data. This has enabled researchers to reuse and reanalyze existing datasets with the aim of generating novel and or more robust information. In this work, after a systematic search, nine microarray datasets evaluating host gene expression in leprosy were reanalyzed and the information was integrated to strengthen evidence of differential expression for several genes.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45064/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMiltonMoraes_ThiagoLCalvo_IOC_2020.pdfMiltonMoraes_ThiagoLCalvo_IOC_2020.pdfapplication/pdf1339129https://www.arca.fiocruz.br/bitstream/icict/45064/2/MiltonMoraes_ThiagoLCalvo_IOC_2020.pdfe2ccdc9340599a302e4dad7105db05f0MD52TEXTMiltonMoraes_ThiagoLCalvo_IOC_2020.pdf.txtMiltonMoraes_ThiagoLCalvo_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Reanalysis And Integration Of Public Microarray Datasets Reveals Novel Host Genes Modulated In Leprosy
title Reanalysis And Integration Of Public Microarray Datasets Reveals Novel Host Genes Modulated In Leprosy
spellingShingle Reanalysis And Integration Of Public Microarray Datasets Reveals Novel Host Genes Modulated In Leprosy
Calvo, Thyago Leal
Reanálise
Dados públicos
Microarray
Novos genes hospedeiros
Hanseníase
Leprosy
Reanalysis
Public Datasets
Microarray
Novel Host Genes
title_short Reanalysis And Integration Of Public Microarray Datasets Reveals Novel Host Genes Modulated In Leprosy
title_full Reanalysis And Integration Of Public Microarray Datasets Reveals Novel Host Genes Modulated In Leprosy
title_fullStr Reanalysis And Integration Of Public Microarray Datasets Reveals Novel Host Genes Modulated In Leprosy
title_full_unstemmed Reanalysis And Integration Of Public Microarray Datasets Reveals Novel Host Genes Modulated In Leprosy
title_sort Reanalysis And Integration Of Public Microarray Datasets Reveals Novel Host Genes Modulated In Leprosy
author Calvo, Thyago Leal
author_facet Calvo, Thyago Leal
Moraes, Milton Ozório
author_role author
author2 Moraes, Milton Ozório
author2_role author
dc.contributor.author.fl_str_mv Calvo, Thyago Leal
Moraes, Milton Ozório
dc.subject.other.pt_BR.fl_str_mv Reanálise
Dados públicos
Microarray
Novos genes hospedeiros
Hanseníase
topic Reanálise
Dados públicos
Microarray
Novos genes hospedeiros
Hanseníase
Leprosy
Reanalysis
Public Datasets
Microarray
Novel Host Genes
dc.subject.en.pt_BR.fl_str_mv Leprosy
Reanalysis
Public Datasets
Microarray
Novel Host Genes
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2020-12-21T20:16:21Z
dc.date.available.fl_str_mv 2020-12-21T20:16:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CALVO, Thiago Leal; MORAES, Milton Ozório. Reanalysis and integration of public microarray datasets reveals novel host genes modulated in Leprosy. bioRxiv, p. 1-23, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/45064
dc.identifier.issn.pt_BR.fl_str_mv 1617-4615
dc.identifier.doi.none.fl_str_mv 10.1101/824805
dc.identifier.eissn.none.fl_str_mv 1617-4623
identifier_str_mv CALVO, Thiago Leal; MORAES, Milton Ozório. Reanalysis and integration of public microarray datasets reveals novel host genes modulated in Leprosy. bioRxiv, p. 1-23, 2019.
1617-4615
10.1101/824805
1617-4623
url https://www.arca.fiocruz.br/handle/icict/45064
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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