Evolution of HTLV-1 proviral load in patients from Salvador, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15071 |
Resumo: | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo a Pesquisa da Bahia (FAPESB) |
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Olavarria, Viviana NillaGomes, Alline do NascimentoKruschewsky, Ramon de AlmeidaCastro Filho, Bernardo GalvãoGrassi, Maria Fernanda Rios2016-07-22T13:12:16Z2016-07-22T13:12:16Z2012OLAVARRIA, V. N. et al. Evolution of HTLV-1 proviral load in patients from Salvador, Brazil. Brazilian Journal of Infectious Diseases, v. 16, n. 4, p. 357-360, 2012.1413-8670https://www.arca.fiocruz.br/handle/icict/1507110.1016/j.bjid.2012.06.022Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo a Pesquisa da Bahia (FAPESB)Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Baiana de Medicina e Saúde Pública. EBMSP. Salvador, BA, BrasilEscola Baiana de Medicina e Saúde Pública. EBMSP. Salvador, BA, BrasilEscola Baiana de Medicina e Saúde Pública. EBMSP. Salvador, BA, BrasilFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Baiana de Medicina e Saúde Pública. EBMSP. Salvador, BA, BrasilFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Baiana de Medicina e Saúde Pública. EBMSP. Salvador, BA, BrasilIntroduction: Variations in human T cell lymphotropic virus type 1 (HTLV-1) proviral load (PVL) in infected individuals over time are not well understood. Objective: To evaluate the evolution of proviral load in asymptomatic individuals and HAM/TSP patients in order to help determine periodicity for measuring proviral load. Methods: A group of 104 HTLV-1 infected patients, followed at the HTLV reference center in Salvador, Brazil, were included in the study (70 asymptomatic and 34 HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients). HTLV-1 PVL was measured using real-time polymerase chain reaction (PCR) at baseline and again at another point, either ≤ 12 months, between 12-24 months, or ≥ 24 months. Results: HAM/TSP patients had higher PVL (ranging from 11,041 to 317,009 copies/106 PBMC) when compared to asymptomatic individuals (ranging from0 to 68,228 copies/106 PBMC). No statistically significant differenceswere observed in the medians of PVL in HAM/TSP patients or asymptomatic individuals over time. However, in asymptomatic individuals with a PVL below50,000 copies/106 PBMC, a statistically significant two-fold increasewas observed over time. Conclusion: HTLV-1-PVL remained stable in both asymptomatic individuals and HAM/TSP patients over time. Frequent monitoring of asymptomatic individuals with low PVLs is recommended and further studies should be conducted to assess the course of PVL in these patients over extended periods of time.engElsevierEvolution of HTLV-1 proviral load in patients from Salvador, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAsymptomaticEvolutionHTLV-1Proviral loadHAM/TSPinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15071/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALOlavarria V N Evolution of HTLV-1....pdfOlavarria V N Evolution of HTLV-1....pdfapplication/pdf149421https://www.arca.fiocruz.br/bitstream/icict/15071/2/Olavarria%20V%20N%20Evolution%20of%20HTLV-1....pdfea7ecc43dd19c05ca7e76a42de53a4e8MD52TEXTOlavarria V N Evolution of HTLV-1....pdf.txtOlavarria V N 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| dc.title.pt_BR.fl_str_mv |
Evolution of HTLV-1 proviral load in patients from Salvador, Brazil |
| title |
Evolution of HTLV-1 proviral load in patients from Salvador, Brazil |
| spellingShingle |
Evolution of HTLV-1 proviral load in patients from Salvador, Brazil Olavarria, Viviana Nilla Asymptomatic Evolution HTLV-1 Proviral load HAM/TSP |
| title_short |
Evolution of HTLV-1 proviral load in patients from Salvador, Brazil |
| title_full |
Evolution of HTLV-1 proviral load in patients from Salvador, Brazil |
| title_fullStr |
Evolution of HTLV-1 proviral load in patients from Salvador, Brazil |
| title_full_unstemmed |
Evolution of HTLV-1 proviral load in patients from Salvador, Brazil |
| title_sort |
Evolution of HTLV-1 proviral load in patients from Salvador, Brazil |
| author |
Olavarria, Viviana Nilla |
| author_facet |
Olavarria, Viviana Nilla Gomes, Alline do Nascimento Kruschewsky, Ramon de Almeida Castro Filho, Bernardo Galvão Grassi, Maria Fernanda Rios |
| author_role |
author |
| author2 |
Gomes, Alline do Nascimento Kruschewsky, Ramon de Almeida Castro Filho, Bernardo Galvão Grassi, Maria Fernanda Rios |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Olavarria, Viviana Nilla Gomes, Alline do Nascimento Kruschewsky, Ramon de Almeida Castro Filho, Bernardo Galvão Grassi, Maria Fernanda Rios |
| dc.subject.en.pt_BR.fl_str_mv |
Asymptomatic Evolution HTLV-1 Proviral load HAM/TSP |
| topic |
Asymptomatic Evolution HTLV-1 Proviral load HAM/TSP |
| description |
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo a Pesquisa da Bahia (FAPESB) |
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2012 |
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2012 |
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2016-07-22T13:12:16Z |
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2016-07-22T13:12:16Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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OLAVARRIA, V. N. et al. Evolution of HTLV-1 proviral load in patients from Salvador, Brazil. Brazilian Journal of Infectious Diseases, v. 16, n. 4, p. 357-360, 2012. |
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https://www.arca.fiocruz.br/handle/icict/15071 |
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1413-8670 |
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10.1016/j.bjid.2012.06.022 |
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OLAVARRIA, V. N. et al. Evolution of HTLV-1 proviral load in patients from Salvador, Brazil. Brazilian Journal of Infectious Diseases, v. 16, n. 4, p. 357-360, 2012. 1413-8670 10.1016/j.bjid.2012.06.022 |
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