Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/3071 |
Resumo: | Acesso ao texto completo: http://onlinelibrary.wiley.com/doi/10.1002/jmv.22087/pdf |
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Grassi, Maria Fernanda RiosOlavarria, Viviana NillaKruschewsky, Ramon de AlmeidaMascarenhas, Rita ElizabethDourado, Maria Inês CostaCorreia, Luis Cláudio LemosCosta, Carlos Maurıcio de CastroCastro, Bernardo GalvãoGrassi, Maria Fernanda RiosOlavarria, Viviana NillaKruschewsky, Ramon de AlmeidaMascarenhas, Rita ElizabethDourado, Maria Inês CostaCorreia, Luis Cláudio LemosCosta, Carlos Maurıcio de CastroCastro, Bernardo Galvão2011-10-04T14:10:14Z2011-10-04T14:10:14Z20110146-6615http://www.repositorio.ufba.br/ri/handle/ri/3071v.83, n.7, p.1269-74, 2011.Acesso ao texto completo: http://onlinelibrary.wiley.com/doi/10.1002/jmv.22087/pdfA high human T-cell lymphotropic virus type 1 (HTLV-1) proviral load is described in HTLV-1-associated diseases, especially HAM/TSP. However, the cut-off value to define high levels of HTLV-1 proviral load is not well established. 281 HTLV-1-infected patients from the HTLV reference center in Salvador, Brazil, were followed from 2005 to 2008. Patients were classified as asymptomatic, possible-, probable-, and definite-HAM/TSP, in accordance with diagnostic criteria proposed by De Castro-Costa et al. (2006): AIDS Res Hum Retroviruses 22:931–935. HTLV-1 proviral load was determined using real-time PCR. A receiver operator characteristic (ROC) curve was constructed using only asymptomatic individuals and definite-HAM/TSP patients. The ROC curve was used to predict the proviral load level that differentiates these two groups. Out of 281 patients, 189 were asymptomatic and 92 were diagnosed with HAM/TSP (22 possible, 23 probable, 47 definite). The mean HTLV-1 proviral load was higher in possible- (89,104 ± 93,006 copies/106 PBMC), -probable (175,854 ± 128,083 copies/106 PBMC), and definite-HAM/TSP patients (150,667 ± 122,320 copies/106 PBMC), when compared to asymptomatic individuals (27,178 ± 41,155 copies/106 PBMC) (P < 0.0001). A comparison of all HAM/TSP groups showed the highest proviral loads in probable-HAM/TSP patients, yet the differences in mean values were not statistically significant. The ROC curve suggested a value of 49,865 copies/106 PBMC, with 87% sensitivity (95% CI = 74–95) and 81% specificity (95% CI = 75–86), as the best proviral load cut-off point to differentiate definite HAM/TSP patients from asymptomatic individuals. HTLV-1 proviral loads are higher in groups of infected patients with neurological symptoms and may represent a relevant biological marker of disease progression.Submitted by Maria Creuza Silva (mariakreuza@yahoo.com.br) on 2011-10-04T14:10:14Z No. of bitstreams: 1 Abstarct Journal of Medical Virology 83.doc: 27136 bytes, checksum: a6d5746a0b92108d01cf09836bb30a2d (MD5)Made available in DSpace on 2011-10-04T14:10:14Z (GMT). No. of bitstreams: 1 Abstarct Journal of Medical Virology 83.doc: 27136 bytes, checksum: a6d5746a0b92108d01cf09836bb30a2d (MD5) Previous issue date: 2011New YorkHTLV-1Proviral LoadBiomarkerHAM/TSPBrazilHuman T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSPJ Med Virolinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALAbstarct Journal of Medical Virology 83.docAbstarct Journal of Medical Virology 83.docapplication/msword27136https://repositorio.ufba.br/bitstream/ri/3071/1/Abstarct%20Journal%20of%20Medical%20Virology%2083.doca6d5746a0b92108d01cf09836bb30a2dMD51LICENSElicense.txtlicense.txttext/plain1907https://repositorio.ufba.br/bitstream/ri/3071/2/license.txtff4bdd9ec3f07e45f5df2f357458313fMD52TEXTAbstarct Journal of Medical Virology 83.doc.txtAbstarct Journal of Medical Virology 83.doc.txtExtracted texttext/plain2087https://repositorio.ufba.br/bitstream/ri/3071/3/Abstarct%20Journal%20of%20Medical%20Virology%2083.doc.txt6cea2d490ffe6aaff43d7f72769bfcffMD53ri/30712022-07-05 14:03:28.664oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:28Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP |
dc.title.alternative.pt_BR.fl_str_mv |
J Med Virol |
title |
Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP |
spellingShingle |
Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP Grassi, Maria Fernanda Rios HTLV-1 Proviral Load Biomarker HAM/TSP Brazil |
title_short |
Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP |
title_full |
Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP |
title_fullStr |
Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP |
title_full_unstemmed |
Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP |
title_sort |
Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP |
author |
Grassi, Maria Fernanda Rios |
author_facet |
Grassi, Maria Fernanda Rios Olavarria, Viviana Nilla Kruschewsky, Ramon de Almeida Mascarenhas, Rita Elizabeth Dourado, Maria Inês Costa Correia, Luis Cláudio Lemos Costa, Carlos Maurıcio de Castro Castro, Bernardo Galvão |
author_role |
author |
author2 |
Olavarria, Viviana Nilla Kruschewsky, Ramon de Almeida Mascarenhas, Rita Elizabeth Dourado, Maria Inês Costa Correia, Luis Cláudio Lemos Costa, Carlos Maurıcio de Castro Castro, Bernardo Galvão |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Grassi, Maria Fernanda Rios Olavarria, Viviana Nilla Kruschewsky, Ramon de Almeida Mascarenhas, Rita Elizabeth Dourado, Maria Inês Costa Correia, Luis Cláudio Lemos Costa, Carlos Maurıcio de Castro Castro, Bernardo Galvão Grassi, Maria Fernanda Rios Olavarria, Viviana Nilla Kruschewsky, Ramon de Almeida Mascarenhas, Rita Elizabeth Dourado, Maria Inês Costa Correia, Luis Cláudio Lemos Costa, Carlos Maurıcio de Castro Castro, Bernardo Galvão |
dc.subject.por.fl_str_mv |
HTLV-1 Proviral Load Biomarker HAM/TSP Brazil |
topic |
HTLV-1 Proviral Load Biomarker HAM/TSP Brazil |
description |
Acesso ao texto completo: http://onlinelibrary.wiley.com/doi/10.1002/jmv.22087/pdf |
publishDate |
2011 |
dc.date.accessioned.fl_str_mv |
2011-10-04T14:10:14Z |
dc.date.available.fl_str_mv |
2011-10-04T14:10:14Z |
dc.date.issued.fl_str_mv |
2011 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://www.repositorio.ufba.br/ri/handle/ri/3071 |
dc.identifier.issn.none.fl_str_mv |
0146-6615 |
dc.identifier.number.pt_BR.fl_str_mv |
v.83, n.7, p.1269-74, 2011. |
identifier_str_mv |
0146-6615 v.83, n.7, p.1269-74, 2011. |
url |
http://www.repositorio.ufba.br/ri/handle/ri/3071 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal da Bahia (UFBA) |
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