Inflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/14513 |
Resumo: | Universidade Federal do Rio Grande do Norte. Departamento de Microbiologia e Parasiologia. Natal, RN, Brasil |
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Guedes, Paulo Marcos MattaAndrade, Cléber Mesquita deNunes, Daniela FerreiraPereira, Nathalie de SenaQueiroga, Tamyres Bernadete DantasCoelho, George Luiz Lins MachadoNascimento, Manuela Sales LimaMatta, Maria Adelaide Do ValleCâmara, Antônia Cláudia Jácome daChiari, EglerGalvão, Lúcia Maria da Cunha2016-06-19T19:21:52Z2016-07-08T12:21:49Z2016-06-19T19:21:52Z2016-07-08T12:21:49Z2016GUEDES, Paulo Marcos Matta; et al. Inflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patients. PLoS Negl Trop Dis., v.10, n.4, 18p, e0004669. Apr. 2016.1935-2727https://www.arca.fiocruz.br/handle/icict/1451310.1371/journal.pntd.00046691935-2735engPublic Library of ScienceRiscos de morteRiscos de acidente vascular encefálicoChronic Chagas DiseaseInflammationTrypanosoma cruziRisks of StrokeRisks of DeathTrypanosoma cruziChagas DiseaseInflamaçãoInflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio Grande do Norte. Departamento de Microbiologia e Parasiologia. Natal, RN, BrasilUniversidade do Estado do Rio Grande do Norte. Departamento de Ciências Biomédicas. Mossoró, RN, Brasil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade Federal do Rio Grande do Norte. Departamento de Microbiologia e Parasiologia. Natal, RN, Brasil / Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade Federal do Rio Grande do Norte. Departamento de Microbiologia e Parasiologia. Natal, RN, BrasilUniversidade Federal de Ouro Preto. Escola de Medicina. Ouro Preto, MG, Brasil.Univrsidade de São Paulo. Escola de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório deUltraestrutura Celular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Norte. Departmaneto de Análises Clínicas e Toxicológicas. Natal, RN, Brasil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Ischemic strokes have been implicated as a cause of death in Chagas disease patients. Inflammation has been recognized as a key component in all ischemic processes, including the intravascular events triggered by vessel interruption, brain damage and repair. In this study, we evaluated the association between inflammatory markers and the death risk (DR) and stroke risk (SR) of patients with different clinical forms of chronic Chagas disease. The mRNA expression levels of cytokines, transcription factors expressed in the adaptive immune response (Th1, Th2, Th9, Th17, Th22 and regulatory T cell), and iNOS were analyzed by realtime PCR in peripheral blood mononuclear cells of chagasic patients who exhibited the indeterminate, cardiac, digestive and cardiodigestive clinical forms of the disease, and the levels of these transcripts were correlated with the DR and SR. Cardiac patients exhibited lowermRNA expression levels of GATA-3, FoxP3, AHR, IL-4, IL-9, IL-10 and IL-22 but exhibited higher expression of IFN-γ and TNF-α compared with indeterminate patients. Digestive patients showed similar levels of GATA-3, IL-4 and IL-10 than indeterminate patients. Cardiodigestive patients exhibited higher levels of TNF-α compared with indeterminate and digestive patients. Furthermore, we demonstrated that patients with high DR and SR exhibited lower GATA-3, FoxP3, and IL-10 expression and higher IFN-γ, TNF-α and iNOS mRNA expression than patients with low DR and SR. A negative correlation was observed between Foxp3 and IL-10 mRNA expression and the DR and SR. Moreover, TNF-α and iNOS expression was positively correlated with DR and SR. Our data suggest that an inflammatory imbalance in chronic Chagas disease patients is associated with a high DR and SR. This study provides a better understanding of the stroke pathobiology in the general population and might aid the development of therapeutic strategies for controlling the morbidity and mortality of Chagas disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTmariaadelaide_matta_etal_IOC_2016.pdf.txtmariaadelaide_matta_etal_IOC_2016.pdf.txtExtracted texttext/plain58546https://www.arca.fiocruz.br/bitstream/icict/14513/4/mariaadelaide_matta_etal_IOC_2016.pdf.txtd1a8f1e931ab9591fce414aa980fdaa1MD54ORIGINALmariaadelaide_matta_etal_IOC_2016.pdfapplication/pdf749988https://www.arca.fiocruz.br/bitstream/icict/14513/2/mariaadelaide_matta_etal_IOC_2016.pdf989d8777a371bcd276efecde9a5d4214MD52LICENSElicense.txttext/plain2991https://www.arca.fiocruz.br/bitstream/icict/14513/3/license.txt5a560609d32a3863062d77ff32785d58MD53icict/145132022-06-24 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| dc.title.pt_BR.fl_str_mv |
Inflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patients |
| title |
Inflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patients |
| spellingShingle |
Inflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patients Guedes, Paulo Marcos Matta Riscos de morte Riscos de acidente vascular encefálico Chronic Chagas Disease Inflammation Trypanosoma cruzi Risks of Stroke Risks of Death Trypanosoma cruzi Chagas Disease Inflamação |
| title_short |
Inflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patients |
| title_full |
Inflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patients |
| title_fullStr |
Inflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patients |
| title_full_unstemmed |
Inflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patients |
| title_sort |
Inflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patients |
| author |
Guedes, Paulo Marcos Matta |
| author_facet |
Guedes, Paulo Marcos Matta Andrade, Cléber Mesquita de Nunes, Daniela Ferreira Pereira, Nathalie de Sena Queiroga, Tamyres Bernadete Dantas Coelho, George Luiz Lins Machado Nascimento, Manuela Sales Lima Matta, Maria Adelaide Do Valle Câmara, Antônia Cláudia Jácome da Chiari, Egler Galvão, Lúcia Maria da Cunha |
| author_role |
author |
| author2 |
Andrade, Cléber Mesquita de Nunes, Daniela Ferreira Pereira, Nathalie de Sena Queiroga, Tamyres Bernadete Dantas Coelho, George Luiz Lins Machado Nascimento, Manuela Sales Lima Matta, Maria Adelaide Do Valle Câmara, Antônia Cláudia Jácome da Chiari, Egler Galvão, Lúcia Maria da Cunha |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Guedes, Paulo Marcos Matta Andrade, Cléber Mesquita de Nunes, Daniela Ferreira Pereira, Nathalie de Sena Queiroga, Tamyres Bernadete Dantas Coelho, George Luiz Lins Machado Nascimento, Manuela Sales Lima Matta, Maria Adelaide Do Valle Câmara, Antônia Cláudia Jácome da Chiari, Egler Galvão, Lúcia Maria da Cunha |
| dc.subject.other.pt_BR.fl_str_mv |
Riscos de morte Riscos de acidente vascular encefálico |
| topic |
Riscos de morte Riscos de acidente vascular encefálico Chronic Chagas Disease Inflammation Trypanosoma cruzi Risks of Stroke Risks of Death Trypanosoma cruzi Chagas Disease Inflamação |
| dc.subject.en.pt_BR.fl_str_mv |
Chronic Chagas Disease Inflammation Trypanosoma cruzi Risks of Stroke Risks of Death |
| dc.subject.decs.pt_BR.fl_str_mv |
Trypanosoma cruzi Chagas Disease Inflamação |
| description |
Universidade Federal do Rio Grande do Norte. Departamento de Microbiologia e Parasiologia. Natal, RN, Brasil |
| publishDate |
2016 |
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2016-06-19T19:21:52Z 2016-07-08T12:21:49Z |
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2016-06-19T19:21:52Z 2016-07-08T12:21:49Z |
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2016 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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GUEDES, Paulo Marcos Matta; et al. Inflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patients. PLoS Negl Trop Dis., v.10, n.4, 18p, e0004669. Apr. 2016. |
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https://www.arca.fiocruz.br/handle/icict/14513 |
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1935-2727 |
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10.1371/journal.pntd.0004669 |
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1935-2735 |
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GUEDES, Paulo Marcos Matta; et al. Inflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patients. PLoS Negl Trop Dis., v.10, n.4, 18p, e0004669. Apr. 2016. 1935-2727 10.1371/journal.pntd.0004669 1935-2735 |
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